1,720,990 research outputs found
Replication Data for: Modelling Policy Action Using Natural Language Processing: Evidence for a Long-Run Increase in Policy Activism in the UK
No full textDFM dataframe and R code for replication. Note that lines 1-219 require access to the original pdf/html documents
Replication Data for: Fiscality, Regulation, and Policy Choice: Evidence From Declassified British Cabinet Minutes 1981-1997
No full textThe stata_code script contains Stata code for most results. The associated data is replication_dta.dta. Additionally, the replication_rf and associated file refers to random forests estimated in R, and replication_stm to the structural topic model presented in the appendix. The file stata_code_app.do contains the script for replicating the permutation tests in appendix 3. Please get in touch for more details on any of the above
Effect of Experimental Drug S107 on Accessory Protein Binding to the RyR
No full textFaculty adviser: Razvan CorneaThe physiological basis of muscle-generated motor activity depends on the precise regulation of intracellular Ca2+ ions. Central to this process is the sarcoplasmic reticulum (SR), a special organelle in muscle cells that is responsible for ion storage. The Ca2+ ions are released from the SR through a large conductance channel known as the ryanodine receptor (RyR). The channel’s activity is in turn regulated by intracellular messengers, including FK506 binding proteins (FKBP12.6 & 12.0), and calmodulin (CaM). The experimental heart failure drug S107 has been associated with improved muscle performance, though it is still unclear if it directly affects the binding activity of either the FKBPs or CaM. Here, the effect of S107 on the binding of fluorescent FKBPs and CaM to RyR is characterized. The results show that S107 slightly, but significantly, decreases the binding affinity of CaM; though, only in nanomolar calcium concentrations, and when the RyR is treated with oxidized glutathione. S107 has no significant effect on the binding of FKBP to RyR. Prior to this research, it was thought that S107 might significantly increase the binding affinity of FKBP. The effect of S107 on CaM binding to RyR has not been previously investigated. These results suggest that the primary mechanism through which S107 achieves its physiological effects does not require or affect FKBP binding. Further studies will have to determine whether the effect of S107 on CaM binding to RyR is linked to the inhibition of Ca2+ leak in the channel.This research was supported by the Undergraduate Research Opportunities Program (UROP). Also, National Institutes of Health (Grant HL92097)Popa, Mircea Anton. (2012). Effect of Experimental Drug S107 on Accessory Protein Binding to the RyR. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/123409
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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