126 research outputs found
Pemphigus: Insights in diagnosis and pathogenesis
No full textPemphigus is een ernstige ziekte die zich kenmerkt door blaarvorming van de huid en/of de slijmvliezen. De blaren worden veroorzaakt door auto-antilichamen die gericht zijn tegen specifieke eiwitten in de huid. Deze eiwitten, genaamd desmogleines, zijn componenten van desmosomen, eiwitcomplexen van belang voor de intercellulaire adhesie. Er bestaan verschillende subtypes van pemphigus, waaronder het potentieel dodelijke subtype paraneoplastische pemphigus (PNP). De diagnose van PNP is uitdagend omdat PNP kan lijken op andere aandoeningen. Verder is er veel discussie over welke mechanismen betrokken zijn bij blaarvorming in pemphigus. Dit proefschrift heeft als doel om de diagnose van PNP te verbeteren, en meer inzicht te krijgen in de mechanismen van blaarvorming in pemphigus. We laten onder andere zien dat de relatief simpele en goedkope combinatie van indirecte immuunfluorescentie microscopie op rattenblaas samen met immunoblot als diagnostische methode, een goed alternatief is voor het meer complexe immuunprecipitatie. Met behulp van diverse microscopische technieken hebben we tevens de slijmvliezen en huid van patiënten met pemphigus foliaceus (PF), die blaren van alleen de huid ontwikkelen, bestudeerd. We zagen dat er herrangschikking van desmogleines buiten het desmosoom plaats vindt. Deze herrangschikking resulteert in de verkleining van desmosomen, zelfs in mondslijmvliezen die gezond lijken. Sommige patiënten ervaren meer blaren na UV blootstelling, en bij deze patiënten zagen we dat desmogleines zijn gekliefd. Concluderend draagt het onderzoek in dit proefschrift bij aan een verbeterde diagnostiek van PNP en verschaft het nieuwe inzichten in het mechanisme van blaarvorming in pemphigus
Pemphigus:Insights in diagnosis and pathogenesis
No full textPemphigus is een ernstige ziekte die zich kenmerkt door blaarvorming van de huid en/of de slijmvliezen. De blaren worden veroorzaakt door auto-antilichamen die gericht zijn tegen specifieke eiwitten in de huid. Deze eiwitten, genaamd desmogleines, zijn componenten van desmosomen, eiwitcomplexen van belang voor de intercellulaire adhesie. Er bestaan verschillende subtypes van pemphigus, waaronder het potentieel dodelijke subtype paraneoplastische pemphigus (PNP). De diagnose van PNP is uitdagend omdat PNP kan lijken op andere aandoeningen. Verder is er veel discussie over welke mechanismen betrokken zijn bij blaarvorming in pemphigus. Dit proefschrift heeft als doel om de diagnose van PNP te verbeteren, en meer inzicht te krijgen in de mechanismen van blaarvorming in pemphigus.We laten onder andere zien dat de relatief simpele en goedkope combinatie van indirecte immuunfluorescentie microscopie op rattenblaas samen met immunoblot als diagnostische methode, een goed alternatief is voor het meer complexe immuunprecipitatie.Met behulp van diverse microscopische technieken hebben we tevens de slijmvliezen en huid van patiënten met pemphigus foliaceus (PF), die blaren van alleen de huid ontwikkelen, bestudeerd. We zagen dat er herrangschikking van desmogleines buiten het desmosoom plaats vindt. Deze herrangschikking resulteert in de verkleining van desmosomen, zelfs in mondslijmvliezen die gezond lijken. Sommige patiënten ervaren meer blaren na UV blootstelling, en bij deze patiënten zagen we dat desmogleines zijn gekliefd. Concluderend draagt het onderzoek in dit proefschrift bij aan een verbeterde diagnostiek van PNP en verschaft het nieuwe inzichten in het mechanisme van blaarvorming in pemphigus.Pemphigus is a severe disease characterized by blistering of skin and/or mucosa.These blisters are caused by autoantibodies directed against specific proteins in the skin. These proteins, called desmogleins, mediate cell-cell adhesion, and are part of a protein complex called the desmosome. Several pemphigus subtypes exist, including the rare but severe subtype paraneoplastic pemphigus (PNP), and the diagnosis of this subtype is challenging because its manifestations can mimic other diseases. Furthermore, there is much debate regarding the cellular mechanisms that lead to blister formation. In this thesis we aimed to improve the diagnosis of PNP, and to gain more insight into blister formation. We compared several laboratory techniques in their ability to detect autoantibodies in the serum of PNP patients, and found that combination of two relatively simple and cheap techniques, namely immunoblotting and indirect immunofluorescence microscopy on rat bladder, is a good alternative to the more elaborate technique of immunoprecipitation, as diagnostic tool. We furthermore used several microscopic techniques to examine desmogleins and desmosomes in the skin and mucosa of patients with pemphigus foliaceus, who develop blistering of only the skin. We found that specific desmogleins are rearranged into clusters outside of desmosomes. This leads to the shrinkage of desmosomes, even in intact oral mucosa. In addition, some patients experience worsened blistering after UV-exposure, and we found that in the skin of these patients, desmogleins are cleaved. In conclusion, these studies improve the diagnosis of PNP and advance our insights into the molecular aspects of blistering in pemphigus
The heat is on: examining the weights of factors influencing the choice between residential heating systems and their differences across the Netherlands
No full textElectrical Engineering | Sustainable Energy Technolog
Re-Razvitak: Spaces of encounter in a divisive city
No full textBosnia and Herzegovina is a country that has endured many wars, through many different rules. The Yugoslav wars from 1991-1996 still linger in Mostar today, as we find a ‘divided city’, which is mostly enforced through institutions that ethnically divide public buildings. At the same time, citizens find this unnecessary and consider Mostar as ‘one’, as they move all over the city. Fountains in public places, particularly the ones with drinking water, used to be a major inclusive quality as a common good that were able to be used by anyone. Currently these are left neglected from a lack of responsibility to take care of these. Using these places as a spatial method to analyze the city, their inclusive qualities are utilized into creating an inclusive place where people can encounter each other, exchange and share knowledge, collaborate and essentially can reclaim public space. 'Inclusive' in this project refers to accessibility and a sense of ownership, where people are able to add a piece of themselves in the program. An existing ruin that used to be a popular department store called Razvitak, resides between two popular streets and through that holds potential to connect a new inclusive place to an existing social tissue. Razvitak plays the role to be unlocked as a common resource, in order to counteract divisional narratives and reconnect the city socially(and aquatically). The project gives this ruin its third life as a social centre, where the inclusivity is shaped through an experience from public to private, encountering different intimacies along the way that shape diverse spaces of encounter, to which the programme relates, while making use of the structure’s existing qualities.Neretva Recollection: Materiality of War, Flowing Memories and Living ArchiveArchitecture, Urbanism and Building Science
Is it practically possible to comply with the qualifying interest requirement when entering into a section 42 asset-for-share transaction concerning immovable property, given the applicable time of disposal rules and the application of the Companies Act?
No full textThe South African Income Tax Act No 58 of 1962 (“the ITA”) contains several group relief provisions aimed to facilitate corporate restructuring. In the ITA there are various examples of roll-over relief provisions generally that contain no time restrictions, nor which are determined with reference to a specific moment in time. That notwithstanding, section 42 of the ITA, colloquially known as referring to asset for-share transactions, requires a transferor company (the company disposing of an asset) to hold a qualifying interest in a transferee company (the company receiving the asset in exchange for the issue of shares) at the close of day on which the asset is disposed of. Accordingly, the ITA is prescriptive regarding the timing provision and when a qualifying interest in section 42 is required to be held. In this study, the author considers the practical application of the qualifying interest requirement and how compliance with this requirement is problematic when considering other legislative enactments. In doing so, the author identifies possible impediments for compliance with the section 42 qualifying interest requirement and furthermore attempts to adopt an interpretation in which the legislative enactments can either be reconciled or interpreted widely to ensure that the requirements of the ITA are complied with. The aim of this study and the question that the author attempted to address in its analysis above is whether it is practically possible to comply with the qualifying interest requirement when entering into a section 42 asset-for-share transaction concerning immovable property, given the applicable time of disposal rules and the application of the Companies Act? In this study and as part of the key findings of this paper, the author identifies several ambiguities arising from the application of various legislative enactments. The Companies Act and the impediments imposed by it to comply with the “qualifying interest” requirement enacted in section 42 of the ITA, specifically insofar as the issue of shares for adequate consideration is concerned in clearly highlighted by the author. To align the provisions of the various legislative enactments and in an attempt to reconcile them the author argued that a purposive approach to statutory interpretation should be adopted in which the practical application and functionality of the provision should be called into question
Peer Mentorship in Higher Education
No full textabstract: It is widely accepted that mentorship between people of similar backgrounds and slightly different ages is a mutually beneficial partnership (e.g., Angelique, Kyle, & Taylor, 2002; Yomtov, 2017). Mentoring relationships exist in many forms across the education spectrum, from middle school students interacting with their younger peers to the popular “Big-Little system” adopted by fraternity and sorority groups in U.S. colleges and universities, and beyond educational settings throughout the working world. However, one place where mentoring has received relatively less attention, from researchers as well as from practitioners, is in undergraduate student leadership-focused organizations at the college level
Selling translation rights in trade publishing : case studies of Dutch translations of Afrikaans fiction in the Netherlands and Belgium
No full textDissertation (MIT)--University of Pretoria, 2017.The reading and buying market for Afrikaans fiction is limited due to historical and economical reasons. It can thus be argued that in order to expand the market for South African Afrikaans trade publishers and authors' novels, a work needs to be translated via the selling of translation rights with the assistance of the publisher or literary agents, into a language that has similar needs in terms of cultural consumption, for example book reading culture. Due to the colonial influence of the Dutch on South African culture and the development of Afrikaans, this study explores the selling of translation rights of Afrikaans fiction to trade publishers in The Netherlands and Belgium. The polystem theory is also used to illustrate the movement of languages from a peripheral position to semi-peripheral and central position within a global literary polysystem. A qualitative and exploratory research design is used. Secondary research in the form of a literature review combines theoretical information, clarifies terms and provides context from which primary research develops. In terms of primary research, interviews with key informants in the Belgian, Netherlands and South African publishing industry were conducted. Case studies of South African crime author Deon Meyer, and historical romance author Irma Joubert provide in-depth analysis of success factors, process and factors that influenced the selling of subsidiary rights to Dutch trade publishers. Lastly, visibility and discoverability of Afrikaans fiction on an international rights trading platform, as well as interaction amongst South African and foreign publishers were observed, at the largest book rights fair, the Frankfurt Book Fair. The findings of this study provide practical information and act as reference guide to role players in the publishing industry, including authors, trade publishers and literary agents. Recommendations for best practice in the selling of subsidiary rights are included, as well as initiatives for further research, experimentation, investment and development of the selling of subsidiary rights to European trade publishers to ultimately grow the Afrikaans fiction book buying and reading markets.Information ScienceMISUnrestricte
Student and teacher perceptions of the effectiveness of positive behavioral interventions and supports in a metropolitan Atlanta elementary school, 2017
No full textThe goal of this study was to ascertain student and teacher perceptions of positive behavioral interventions and supports (PBIS) effectiveness as based on PBIS tiers and other select variables: school discipline, school safety, school climate, student acceptance of PBIS reward system and administrators implementation of PBIS policy. Through a Pearson r correlation, analysis of variance (ANOVA), and regression test based on survey results, this study revealed which variables have the greatest significance on PBIS effectiveness. Based on the findings, it was concluded that all variables: school discipline, school safety, school climate, student acceptance of PBIS reward system had a significant effect. Qualitative data of this study supported the findings of the strategical results. Also, it is noted that administrators implementation of discipline policy shown to be significant as a result of the qualitative data. Recommendations were suggested for school leaders, district leaders, policy makers and future research. KEY TERMS: PBIS, Discipline, Positive reinforcement, student behavior, Educational Leadership, Elementary and Middle and Secondary Education Administration, Other Educational Administration and Supervision, Urban Educatio
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