5,670 research outputs found
Analyses of functional sequence in mammalian and avian genomes
Full text linkThe first draft sequence of the human genome was published over a decade ago, yet interpreting the functional importance of nucleotides in genomes is still an ongoing challenge. I took a comparative genomic approach to identify functional sequence using signatures of natural selection in DNA sequences. Mutations that are purged or propagated by selection mark sequences of significance for biological fitness. I developed and refined methods for estimating the quantity of sequence constrained with respect to insertions and deletions (indels) between two genome sequences, a quantity I termed αselIndel. This sequence is evolving more slowly than surrounding neutral sequence due to the purging of deleterious indel variants, and thus this sequence is likely to be functional. I estimated αselIndel between diverse mammalian and avian species pairs, and found a strong negative correlation between αselIndel and the divergence between the species’ genome sequences. This implies that functional sequence turns over rapidly as it is lost and gained over time. I quantified the variable levels of sequence constraint, and rates of sequence turnover, for different types of human biochemically annotated element. Furthermore, I found that similar rates of functional turnover have occurred across mammalian and avian evolution. Finally, I identified positively selected amino acid residues that may be important for Darwin’s finch beak development, and found evidence of adaptively evolving reproductive proteins in the ancestral songbird lineage. Collectively these results demonstrate the wide-spread nature of lineage-specific functional sequence with implications for understanding species traits and the use of model organisms to inform human biology
Sustainable Stoke:Transitions to Sustainability in the Surfing World
Full text linkWhat does sustainability mean in the surfing world? This question is answered by more than 40 of the most influential figures from the surf industry, academia, non-profit organisations, and the surfing community, exploring the cutting edge of the surfing world's transition to sustainability. High profile contributors include: 1) President of the International Surfing Association and founder of Reef, Fernando Aguerre, 2) 1978 World Champion and former CEO of the Association of Surfing Professionals Wayne Rabbit Bartholomew, 3) Professional Surfer, former Waterman of the Year and twice inducted into the Surfer s Hall of Fame Rob Machado, 4) President of the Surf Industry Manufacturers Association Doug Alladini, 5) Founder of Surfrider Foundation Glenn Hening, 6) Co-Founder of Surfers Against Sewage Chris Hines, 7) Fred Hemmings 1968 world champion, founder of the Pipeline Masters and the World Championship Tour, and former state senator, and 8) Bob McKnight former CEO and current chairman of the board at Quiksilver, and many more. Sustainable Stoke systematically explores how surfing culture and industry impacts on social, economic and environmental areas of life at both international and local levels. Innovations and initiatives are highlighted providing the foundations for technological transitions as well as social and environmental initiatives that are improving the lives of thousands of people all over the world
Too Much Information piece commenting on the local media scene. Author Chris B
No full textToo Much Information piece commenting on the local media scene. Author Chris Barry analyzes WGME-13\u27s inclusion of promotions for network entertainment in its news broadcasts; discusses the bi-weekly interviews of former governor Angus King on National Public Radio\u27s Marketplace; and praises Ed King\u27s West End News for its high quality
Intergenic long noncoding RNAs provide a novel layer of post-transcriptional regulation in development and disease
Full text linkRecent genome-wide sequencing projects revealed the pervasive transcription of intergenic long noncoding RNAs (lincRNAs) in eukaryotic genomes (reviewed in Ponting et al. 2009). For the vast majority of lincRNAs, their mechanisms of function remain largely unrecognized. However, the genome-wide signatures of functionality associated with many lincRNAs, including apparent evolutionary sequence conservation, spatial and temporal-restricted expression patterns, strong associations with epigenetic marks, and reported molecular and cellular functions, reinforce their biological relevance. My work investigates lincRNAs that post-transcriptionally regulate gene abundance by competing for the binding of common microRNAs (miRNAs) with protein-coding transcripts, termed competitive endogenous RNAs (ceRNAs) acting lincRNAs (lnceRNAs). First, I examine the biological relevance of this post-transcriptional regulation of gene abundance by ceRNAs. Next, I estimate the genome-wide prevalence of lnceRNAs in mouse embryonic stem cells (mESCs) and characterize their properties. Finally, using two specific examples of lnceRNAs, I show the contributions of lnceRNAs to human monogenic and complex trait diseases. Collectively, these results illustrate that lnceRNAs provide a novel layer of post-transcriptional regulation via a miRNA-mediated mechanism that contributes to organismal and cellular biology
Manzanar camp map, "Manzanar, a photograph essay"
No full textA map of "Manzanar Relocation Center" reproduced from "Manzanar pilgrimage program" by hand by Chris S. Uyemura. The caption reads, "General plan of the W.R.A. Camp at Manzanar, California. Chris Uyemura Collection." A page from: Manzanar, a photograph essay (csudh_uye_0001).The Chris S. Uyemura Manzanar Photograph Collection consists of a pictorial essay, “Manzanar, a photographic essay,” and additional loose photos, which were compiled and collected by Chris S. Uyemura. The essay contains photographs, texts, and newspaper clippings, and was submitted to Professor Donald T. Hata of the Department of History at CSU Dominguez Hills. The collection depicts the incarceration of people of Japanese ancestry in the Manzanar camp during World War II as well as reflects the events, contrasting with photographs of the Manznar National Historic Site, which illustrates what is left of the camp today. The collection was originally named as “Asian Pacific Studies Collection Box 14.
Chris and the Gramophone
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/245818A sled dog stands on the snow looking into the horn of a gramophone which is playing a record. Image by Herbert George Ponting, expedition photographer, during the British Antarctic Expedition 1910-13.
Inscription: 472116701
Item: [1980.0030.00164] "Chris and the Gramophone
John and Chris Crutcher Folder
No full text2 pages of family history documents containing and related to John Crutcher; Chris Crutcher - including: News articles; Valley clerk; Author; obi
Intimacy Unguarded: Chris Kraus
No full textThe Central Saint Martins research project 'Intimacy Unguarded', run by Emma Talbot and Dr Jo Morra, hosted a visit to Central Saint Martins by United States author Chris Kraus. Kraus is a highly respected writer (I Love Dick, Summer of Hate, Aliens and Anorexia etc) and editor of the semi-texte series 'Native Agents'. In this event, Kraus gave a reading from 'I Love Dick' and was then interviewed by Emma Talbot, to a live public audience.
'Intimacy Unguarded' also ran a seminar called 'Write A Letter To Chris Kraus'. Mirroring the format for the celebrated book 'I Love Dick', in which Kraus uses the letter as a way of addressing a particular figure (with whom she is obsessed) whilst simultaneously unpacking her own personal thoughts and research, participants were invited to 'Write a Letter To Chris Kraus'.
Chris Kraus was present at the seminar, where letters were read aloud and Kraus was the first respondent. Those taking part were from Raven Row, CSM BAFA, MAFA and Afterall. An excerpt from Kraus's book and a selection of the letters will be published in the June 2017n issue of Journal of Visual Art Practice, to be guest-edited by Talbot and Morra
Responding to Literature Through Student–Author Interviews: Eighth-Grade Students Challenge Chris Crowe’s Mississippi Trial, 1955
Full text linkThis study explores virtual, student–author interviews eighth-grade students led with Chris Crowe in response to his young adult novel Mississippi Trial, 1955. The opportunity to interview the author motivated students to read the novel. Through their text-world development, students connected with the fictional and nonfictional characters, Hiram Hillburn and Emmett Till, respectively. Through their critical reader-responses, students sought truth about Emmett Till’s case as they questioned Crowe about the choices he made as an author and researcher, which supported students’ understanding of character development and historical significance of Emmett Till’s case. Crowe’s answers to the students’ critical questions were not easy, but through the student–author interview preparation and implementation process, participants captured a shared understanding of Emmett Till’s case and how its connection to the U.S. civil rights movement impacted history and is pertinent today. Ultimately, this article advocates for reader-response pedagogy to include virtual or in-person student–author interviews
Introduction, "Manzanar, a photograph essay"
No full textIntroduction of his photographic essay, "Manzanar, a photographic essay" (csudh_uye_0001). "... to convey to the observer, the conditions in which the evacuees lived, the sights which they way, everyday, for those emotion filled years, and the memories of those years, carved in Limestone ..... to last forever."The Chris S. Uyemura Manzanar Photograph Collection consists of a pictorial essay, “Manzanar, a photographic essay,” and additional loose photos, which were compiled and collected by Chris S. Uyemura. The essay contains photographs, texts, and newspaper clippings, and was submitted to Professor Donald T. Hata of the Department of History at CSU Dominguez Hills. The collection depicts the incarceration of people of Japanese ancestry in the Manzanar camp during World War II as well as reflects the events, contrasting with photographs of the Manznar National Historic Site, which illustrates what is left of the camp today. The collection was originally named as “Asian Pacific Studies Collection Box 14.
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