7 research outputs found
Drafting of legislation in compliance with model laws
No full textThis dissertation gives an analysis and critique of the challenges of drafting domestic legislation in compliance with model laws as regards the quality assurance of legislation. With particular reference to ICAO aviation draft model laws as a case study, the author gives an overview of the impact of model laws on the drafting of quality national legislation, identifying the pros and cons of model laws on the legislative process
Thomas Piketty to address the 13th Nelson Mandela Annual Lecture - 3 October 2015
No full textThe Nelson Mandela Foundation is pleased to announce that French economist Thomas Piketty will deliver the 13th Nelson Mandela Annual Lecture on 3 October 2015. Thomas Piketty, Professor of Economics at the Paris School of Economics, is the author of numerous scholarly works published in journals such as the Quarterly Journal of Economics, the Journal of Political Economy, the American Economic Review and the Review of Economic Studies. He is also the author of a dozen books. But it is his..
WiSER Lecture 13 August : Ricardo Soares de Oliveira on Angola, 6pm
No full textRicardo is Associate Professor in Comparative Politics (African Politics) at the Department of Politics and International Relations, University of Oxford, Official Fellow of St Peter's College, and a Fellow with the Global Public Policy Institute, Berlin. He is the author of Oil and Politics in the Gulf of Guinea (2007), co-editor of China Returns to Africa: A Rising Power and a Continent Embrace (with Chris Alden and Daniel Large, 2008) and The New Protectorates: International Tutelage and ..
Defeating Apartheid: Cuba in Southern Africa / HSRC Seminar 21st November
No full textInvitation HSRC Seminar Series, in partnership with the Institute for Humanities in Africa, UCT, the Wits History Workshop, IFAS and NIHSS Defeating Apartheid: Cuba in Southern Africa Presenters: Presenter: Prof. Piero Gleijeses, School of Advanced International Studies, Johns Hopkins University and author of Visions of Freedom: Havana, Washington, Pretoria and the Struggle for Southern Africa 1976-1991 Chair: Associate Professor Shamil Jeppie, UCT Moderator: Prof. John Stanfield, DGSD, HSRC ..
Defeating Apartheid: Cuba in Southern Africa / HSRC Seminar 21st November
No full textInvitation HSRC Seminar Series, in partnership with the Institute for Humanities in Africa, UCT, the Wits History Workshop, IFAS and NIHSS Defeating Apartheid: Cuba in Southern Africa Presenters: Presenter: Prof. Piero Gleijeses, School of Advanced International Studies, Johns Hopkins University and author of Visions of Freedom: Havana, Washington, Pretoria and the Struggle for Southern Africa 1976-1991 Chair: Associate Professor Shamil Jeppie, UCT Moderator: Prof. John Stanfield, DGSD, HSRC ..
Validation of enzyme immunoassays via an adrenocorticotrophic stimulation test for the non-invasive quantification of stress-related hormone metabolites in naked mole-rats
No full textDATA AVAILABILITY: Data supporting the reported results will be sent by the corresponding
author upon request.SUPPLEMENTARY MATERIALS : TABLE S1: Summary of saline volume and synthetic
adrenocorticotropic hormone (Synacthen® depot, Novartis, South Africa (Pty) Ltd.) administered to
each individual during the ACTH challenge; TABLE S2: Summary of EIA sensitivities and intra-assay
and inter-assay coefficients of variation in high- and low-value quality controls for all EIAs applied to
measure immunoreactive urine glucocorticoid metabolite (uGCM) and fecal glucocorticoid metabolite
in naked mole-rats.Small size in mammals usually restricts long-term, frequent monitoring of endocrine
function using plasma as a matrix. Thus, the non-invasive monitoring of hormone metabolite
concentrations in excreta may provide an invaluable approach. The aim of the current study was
to examine the suitability of enzyme immunoassays (EIAs) for monitoring responses to stressors
in the naked mole-rat (Heterocephalus glaber, NMR) using urine and feces as hormone matrices.
A saline control administration, and a high- and low-dose adrenocorticotropic hormone (ACTH)
challenge were performed on six male and six female disperser morph NMRs. The results revealed
that a 5α-pregnane-3β,11β,21-triol-20-one EIA detecting glucocorticoid metabolites (GCMs) with
a 5α-3β-11β-diol structure is the most suitable assay for measuring concentrations in male urine
samples, whereas an 11-oxoaetiocholanolone EIA detecting GCMs with a 5β-3α-ol-11-one structure
appears the most suitable EIA for quantifying GCMs in female urine. An 11-oxoaetiocholanolone
EIA detecting 11,17 dioxoandrostanes was the most suitable EIA for quantifying GCMs in the feces of
both sexes. There were sex-related differences in response to the high- and low-dose ACTH challenge.
We recommend using feces as a more suitable matrix for non-invasive GCM monitoring for NMRs
which can be valuable when investigating housing conditions and other welfare aspects.SARChI Chair of Mammalian Behavioral Ecology and Physiology from the DST–NRF South Africa and the National Research Foundation.https://www.mdpi.com/journal/animalsMammal Research InstituteZoology and Entomolog
Non-invasive quantification of faecal and urine reproductive hormone metabolites in the naked mole-rat (Heterocephalus glaber)
No full textDATA AVAILABILITY : The data generated and subsequently analysed during this study will be sent by the corresponding author upon request.SUPPLEMENTARY MATERIALS : FIGURE S1: Serial dilutions of faecal extracts for
the 5α-Progesterone EIA. FIGURE S2: Serial dilutions of faecal extracts for the Epiandrosterone EIA.
TABLE S1: Details on EIA antibodies, label, standard, and references for each EIA used in the study.The naked mole-rat (Heterocephalus glaber) occurs in colonies with a distinct dominance hierarchy, including one dominant, breeding female (the queen), 1–3 breeding males, and non-reproductive subordinates of both sexes that are reproductively suppressed while in the colony. To non-invasively evaluate reproductive capacity in the species, we first had to examine the suitability of enzyme immunoassays (EIAs) for determining progestogen and androgen metabolite concentrations in the naked mole-rat, using urine and faeces. A saline control and gonadotrophin-releasing hormone (GnRH) were administered to twelve (six males and six females) naked mole-rats which were previously identified as dispersers and housed singly. The results revealed that urine is possibly not an ideal matrix for progestogen and androgen metabolite quantification in naked mole-rats as no signal was detected in the matrix post GnRH administration. A 5α-Progesterone EIA and an Epiandrosterone EIA were identified as suitable for quantifying faecal progesterone metabolites (fPMs) and faecal androgen metabolites (fAMs) in males and females, respectively. The results suggest that there are individual variations in baseline fPM and fAM concentrations, and only two out of six females and no males exhibited an increase in fPM concentrations greater than 100% (−20% SD) post GnRH administration. Conversely, only four out of six females and three out of six males had an increase in fAM concentrations greater than 100% (−20% SD) following GnRH administration. These results imply that some naked mole-rat individuals have a reduced reproductive capacity even when they are separated from the queen.SARChI Chair of Mammalian Behavioural Ecology and Physiology from the DST–NRF South Africa and the National Research Foundation.https://www.mdpi.com/journal/animalsMammal Research InstituteZoology and Entomolog
