1,720,973 research outputs found
Oxocyclopentenes, Synthesis of 2-Methoxy-4-methyl-3-oxocyclopentene and its Conversion to Di-hydrojasmone
No full textA new synthesis of dihydrojasmone starting from the disodium salt 3,5-diehthoxycarbonil-1,2-dioxocyclopentane,readly avalable by Thaoker-Bagavant procedure ,is reported
A facile alkylation of ethyl 2-oxocyclopentanecarboxylate
No full textA very simple procedure that allows to alkylate the Dieckman ester is reported
Caratteristiche morfologiche e dell'involo dei fagiani di tipo mongolia (Phasianus colchicus mongolicus mongolicus) e tenebrosi (Phasianus colchicus v. tenebrosus) allevati in provincia di Terni
No full textA [3+2]nitrile oxide cycloaddition approach to (-)-pyrenophorin, and rosefuran
No full text[3+2] Nitrile oxide cycloaddition chemistry has been conveniently applied as carbon-carbon bond forming reaction for the assemblage of the functionalized carbon atom fragments required for the synthesis of two simple but different targets such as (-)-pyrenophorin and rosefuran. In both cases, an intermediate 3,5-disubstituted isoxazoline ring system has been used as serviceable precursor of the salient structural feature of the targets
[Carotid endarterectomy with placement of a PUR (polyurethane) patch]
No full textIn this study, 40 patients who underwent surgery for cerebro-vascular insufficiency were considered. Carotid endarterectomy was the procedure of choice in all of the patients; the arteriotomy was always closed using a PUR patch, a new material that, for its chemical and physical characteristics seems to be a good alternative to PTFE. All of the patients underwent surgery under loco-regional anesthesia, allowing a perioperative monitoring of the neurological status through the patient's active collaboration. During the postoperative period, non local or systemic pathology related to the use of the patch has been observed. During the short and half term follow-up, the patients underwent echo-Doppler of the supra-aortic trunks that didn't show either false aneurysms or thrombosis on the patch surface
Synthesis of cis-4-octene-1,8-dioic acid and its esters
No full textThe synthesis of cis-4-octene-1,8-dioic acid is described by ozonolysis of cis,cis-1,5-cyclooctadiene
Elaboration of the ωChain of 11 -Deoxyprostanoid Derivatives through Isoxazole Intermediates
No full textA new versatile approach to the synthesis of ll-deoxyprostanoic acid derivatives, which entails the use of
3,&diaubatituted iaoxazoles as source of the eight carbon atoms of the wchain, is degcribed. The key step involves
the formation of the C(13)<(14) bond through a [3 + 21 cycloaddition of the nitrile oxides generated from
3~-(nitromethyl)-2a-substituted-cyclopentanoncey cloethylene ketals (10,22,31) to l-heptyne to give the corresponding
isoxazoles (12,24,32), the wide chain of 24 and 32 being completed through Wittig condensation
to give 26 and 36. Reductive ring opening of the heterocycle under Birch-like conditions gave rise to the &amino
ketones 14,27, and 37, which underwent a silica gel assisted loss of ammonia to produce the a,b-unsaturated
ketones 15,28, and 38, precursors of the vinylamylcarbinol side chain of prostaglandins (PGs). The alternative
reductive ring opening of the isoxazole 12 allowed us to obtain the allylically transposed enone 19, leading to
a new preparation of 13-hydroxyprostanoic acid derivatives 21
Effects of Lean Thinking and Emerging Technologies on Breast Cancer Patients' Therapeutic Process During COVID-19 Pandemic: A Case-Control Matched Study
Full text linkIntroduction: The advent of the COVID-19 pandemic has led to the sudden disruption of routine medical care, and the subsequent reorganization of hospital structures and therapeutic algorithms, aiming at protecting patients and health professionals. This was inevitably bound to affect our Breast Unit, dilating both pre- and post-operative times. The aim of this study was to evaluate the effect on patients' flow of organizational and logistic changes (key interventions) based on lean thinking implemented after the COVID-19 outbreak.Materials and Methods: Clinical and demographic data were retrospectively collected from patients undergoing sentinel lymph node biopsy for breast cancer at the Verona University Hospital from January 2018 to June 2020. Patients enrolled (n = 341) were divided into two groups according to date of admission: before (Group A; n = 294) and after (Group B; n = 47) the implementation of key interventions. Each case in Group B was subsequently matched 1:1 by means of case-control matching with cases from Group A for age, comorbidities, and type of surgery (Subgroup A1; N = 47). Pre-admission time (T0) and length of stay (T1) were compared between the three groups.Results: Median T0 was 312 h, whereas median T1 was 24 h. Patients in Group B had a higher frequency of comorbidities (57.4 vs. 25.2%, p = 0.001) and underwent mastectomy more often than patients in Group A (61.7 vs. 36.7%, p = 0.001). Both median T0 and T1 were higher in group B than in group A (384 vs. 300 h, p = 0.001, 48 vs. 24 h, p = 0.001, respectively). Median T0 and T1 did not significantly differ between Group B and Subgroup A1 (all p > 0.05).Conclusions: Lean thinking and new technologies could prove useful to the optimization of preoperative and postoperative times during the current pandemic, minimizing healthcare personnel and patients' exposure to SARS-CoV-2, and promoting a rational use of limited resources, while complying with oncological principles
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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