225,380 research outputs found
A comment on "Intergenerational equity: sup, inf, lim sup, and lim inf"
No full textWe reexamine the analysis of Chambers (Social Choice and Welfare, 2009), that produces a characterization of a family of social welfare functions in the context of intergenerational equity: namely, those that coincide with either the sup, inf, lim sup, or lim inf rule. Reinforcement, ordinal covariance, and monotonicity jointly identify such class of rules. We show that the addition of a suitable axiom to this three properties permits to characterize each particular rule. A discussion of the respective distinctive properties is provided.Social welfare function; Intergenerational equity; Lim sup ; Lim inf
Visual improvement in amblyopic eye following treatment induced vision loss in dominant eye with uveal melanoma
No full textMultiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development
No full textThe crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated. In this paper we show that CLIM cofactors are widely expressed during zebrafish development with high protein levels in specific neuronal cell types where LIM-HD proteins of the Isl class are synthesized. The overexpression of a dominant-negative CLIM molecule (DN-CLIM) that contains the LIM interaction domain (LID) during early developmental stages of zebrafish embryos results in an impairment of eye and midbrain-hindbrain boundary (MHB) development and disturbances in the formation of the anterior midline. On a cellular level we show that the outgrowth of peripheral but not central axons from Rohon Beard (RB) and trigeminal sensory neurons is inhibited by DN-CLIM overexpression. We demonstrate a further critical role of CLIM cofactors for axonal outgrowth of motor neurons. Additionally, DN-CLIM overexpression causes an increase of Isl-protein expression levels in specific neuronal cell types, likely due to a protection of the DN-CLIM/LIM-HD complex from proteasomal degradation. Our results demonstrate multiple roles of the CLIM cofactor family for the development of entire organs, axonal outgrowth of specific neurons and protein expression levels
Visual improvement in amblyopic eye following treatment-induced vision loss in dominant eye with uveal melanoma
No full textVisual improvement in amblyopic eye following treatment-induced vision loss in dominant eye with uveal melanoma
No full textVisual improvement in amblyopic eye following treatment-induced vision loss in dominant eye with uveal melanoma
No full textObjective: To determine the frequency and amount of visual improvement in amblyopic eyes of adults following visual loss in the dominant eye resulting from treatment of uveal melanoma. Methods and analysis: Retrospective case series of adult patients with amblyopia and dominant eye visual loss resulting from treatment of uveal melanoma. Review of best-corrected visual acuity (BCVA) in each eye (amblyopia eye vs melanoma eye) at date first seen and over time following treatment of uveal melanoma. BCVA in each eye was graded as improved (>2 logarithm of minimal angle of resolution (logMAR) lines) or unimproved (<2 logMAR lines). Results: Twenty-one patients that met the inclusion criteria. Mean age at presentation was 56 years (range 39-73 years). Following treatment of the uveal melanoma and decline of BCVA in the dominant, the BCVA in the amblyopic eye improved in 11/21 (52%; 95% CI 30% to 74 %) patients. The degree of visual loss in the melanoma eye was to the level of the amblyopic eye or worse in 14 patients. In this group, BCVA improved in the amblyopic eye in 9/14 (64%; 95% CI 35% to 87 %) patients. Of these nine with improved eyes, the mean starting visual acuity was logMAR 0.6 (20/80) with mean improvement of logMAR 0.4 (4 lines±0.13 (range 0.2-0.6). Eight of nine eyes achieved a BCVA of 20/25 (n=3) or 20/20 (n=5). Conclusion: Visual acuity in the amblyopic eye of adults can improve following visual loss in the contralateral dominant eye associated with treatment for uveal melanoma
J.-R. Kupper. — Correspondance de Bahdi-Lim
No full textDussaud René. J.-R. Kupper. — Correspondance de Bahdi-Lim. In: Syria. Tome 31 fascicule 3-4, 1954. pp. 308-309
Four and a half LIM protein 1C (FHL1C)
No full textFour-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy (XMPMA). We here studied myoblasts from XMPMA patients. We found that functional FHL1A protein is completely absent in patient myoblasts. In parallel, expression of FHL1C is either unaffected or increased. Furthermore, a decreased proliferation rate of XMPMA myoblasts compared to controls was observed but an increased number of XMPMA myoblasts was found in the G(0)/G(1) phase. Furthermore, low expression of K(v1.5), a voltage-gated potassium channel known to alter myoblast proliferation during the G(1) phase and to control repolarization of action potential, was detected. In order to substantiate a possible relation between K(v1.5) and FHL1C, a pull-down assay was performed. A physical and direct interaction of both proteins was observed in vitro. In addition, confocal microscopy revealed substantial colocalization of FHL1C and K(v1.5) within atrial cells, supporting a possible interaction between both proteins in vivo. Two-electrode voltage clamp experiments demonstrated that coexpression of K(v1.5) with FHL1C in Xenopus laevis oocytes markedly reduced K(+) currents when compared to oocytes expressing K(v1.5) only. We here present the first evidence on a biological relevance of FHL1C
Rhinolophus chiewkweeae Yoshiyuki and Lim 2005
No full textRhinolophus chiewkweeae Yoshiyuki and Lim, 2005 Rhinolophus chiewkweeae Yoshiyuki and Lim, 2005: 29; Gunung Ledang, Tangkak, Muar, Johor, MALAYSIA, 1276 m (Boo-Liat Lim, collector; NSMT-M 33472) [13]. Common English name: Chiewkwee’s Horseshoe Bat Barcode Index Number: There are no DNA barcodes recorded under this name on BOLD. Remarks: R. pearsonii is reported to occur in Peninsular Malaysia [9] although we could not find any precise locality reports. It is likely that the records of R. pearsonii from Peninsular Malaysia, if valid, may actually represent R. chiewkweeae [154]. However, our NJ analysis revealed that the DNA barcodes under these names (but not including Peninsular Malaysia specimens) were 12% divergent in COI mtDNA (see Fig 3 in [154]). IUCN status: Not Evaluated Recorded at: Melaka: Asahan Forest Reserve [13]; Johor: Gunung Ledang and Labis Forest Reserve [13]; Kedah: Lubok Semilan, Ulu Melaka in Pulau Langkawi and Weng Subcatchment Area in Ulu Muda Forest Reserve Forest Reserve [13]; Perlis: Wang Kelian State Park [50]; Perak: Temenggor Lake [69]; Terengganu: Tasik Kenyir [69], Sungai Buweh [154]. R. chiewkweeae has been reported from lowland, hill and submontane dipterocarp forests, and an island [13, 154]. In Peninsular Malaysia, all reported individuals were caught in mature and secondary dipterocarp forests [154]. The low capture rate of R. chiewkweeae suggested that the population density of the species in Peninsular Malaysia is likely to be very low [50, 154]Published as part of Voon-Ching Lim, Rosli Ramli, Subha Bhassu & John-James Wilson, 2017, A checklist of the bats of Peninsular Malaysia and progress towards a DNA barcode reference library, pp. 1-65 in PLoS ONE 12 (7) on page 30, DOI: 10.1371/journal.pone.0179555, http://zenodo.org/record/425135
Alec Fong Lim
No full textLaunch of 'Litchfield's Gold' by Janet Dickinson. Alec Fong Lim talking to guests. L-R: Janet Dickinson; Alec Fong Lim; Graeme Cheater.Unknown.Date:198
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