52,831 research outputs found
Oral anticoagulants for stroke prevention in patients with atrial fibrillation and previous intracranial hemorrhage
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The relevance of immune reactions in acute favism
No full textIn fava bean extracts the proteins were separated and characterized by gel filtration on Sephadex G 25 columns, cellogel electrophoresis and analytical ultracentrifugation. The dried extract and its chromatographic fractions were used to detect serum antibodies to fava beans by passive hemagglutination tests. 75 patients affected by acute favism were studied by this method. Hemagglutination tests were positive in 5 patients (6.6%) at the onset of the hemolytic crisis but a rapid fall of the titres was observed in the subsequent days. β 1C/β 1A and immunoglobulin levels showed no significant changes. These results do not support the view that hypersensitivity to fava bean may be involved in the hemolysis of acute favism
Il corso integrato di Metodologia clinica : sua sperimentazione e valutazione presso il Polo S. Paolo di Milano
No full textParticipated Strategies for Small Towns Regeneration. The Case of Oliena (Nu) Historic Centre
No full textDealing with the issue of depopulation and abandonment of villages and small towns in Italy and Europe is amongst the goals of the economic and social policies aimed at investigating and experimenting new strategies for the regeneration and reactivation of urban space. An extensive literature collects researches aimed at analysing the problem, exploring diverse management and design approaches, alternative measures to stop the phenomenon and innovative legislative incentives and economic tools. This paper has the aim of reporting an ongoing research experience concerning participated solutions aimed at developing new possible models for the regeneration of Oliena’s historic centre, in Sardinia
Decomposing Training Data to Improve Network Intrusion Detection Performance
No full textAnyone working in the field of network intrusion detection has been able to observe how it involves an everincreasing number of techniques and strategies aimed to overcome the issues that affect the state-of-the-art solutions. Data unbalance and heterogeneity are only some representative examples of them, and each misclassification made in this context could have enormous repercussions in different crucial areas such as, for instance, financial, privacy, and public reputation. This happens because the current scenario is characterized by a huge number of public and private network-based services. The idea behind the proposed work is decomposing the canonical classification process into several sub-processes, where the final classification depends on all the sub-processes results, plus the canonical one. The proposed Training Data Decomposition (TDD) strategy is applied on the training datasets, where it applies a decomposition into regions, according to a defined number of events and features. The reason that leads this process is related to the observation that the same network event could be evaluated in a different manner, when it is evaluated in different time periods and/or when it involves different features. According to this observation, the proposed approach adopts different classification models, each of them trained in a different data region characterized by different time periods and features, classifying the event both on the basis of all model results, and on the basis of the canonical strategy that involves all data
Platelet adhesion and thrombus formation in microchannels : the effect of assay-dependent variables
No full textMicrofluidic flow chambers (MFCs) allow the study of platelet adhesion and thrombus formation under flow, which may be influenced by several variables. We developed a new MFC, with which we tested the effects of different variables on the results of platelet deposition and thrombus formation on a collagen-coated surface. Methods: Whole blood was perfused in the MFC over collagen Type I for 4 min at different wall shear rates (WSR) and different concentrations of collagen-coating solutions, keeping blood samples at room temperature or 37 °C before starting the experiments. In addition, we tested the effects of the antiplatelet agent acetylsalicylic acid (ASA) (antagonist of cyclooxygenase-1, 100 μM) and cangrelor (antagonist of P2Y12, 1 μM). Results: Platelet deposition on collagen (I) was not affected by the storage temperature of the blood before perfusion (room temperature vs. 37 °C); (II) was dependent on a shear rate in the range between 300/s and 1700/s; and (III) was influenced by the collagen concentration used to coat the microchannels up to a value of 10 μg/mL. ASA and cangrelor did not cause statistically significant inhibition of platelet accumulation, except for ASA at low collagen concentrations. Conclusions: Platelet deposition on collagen-coated surfaces is a shear-dependent process, not influenced by the collagen concentration beyond a value of 10 μg/mL. However, the inhibitory effect of antiplatelet drugs is better observed using low concentrations of collagen
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