196,232 research outputs found
Azygophleps aburae Plotz 1880
No full textAzygophleps aburae (Plotz, 1880) (Fig. 45) Zeuzera aburae Plotz, 1880: 77. Type locality. Bei Aburi [Ghana]. Type material. location unknown; lost? Distribution. Zimbabwe, Kenya, Ghana, Cameroon, Malawi, Sudan (Schoorl 1990; Yakovlev 2011). Material examined. 2 males, Dzalanyama forest, Lilongwe distr., C. Malawi, 1300 m, 21.04. 2006, leg. R. Murphy (RMM); 2 males, Ntchisi forest, C. Malawi, 1600 m, 10 – 17.05.2002, leg. R. Murphy (RMM); 1 male, C. Malawi, Kasungu N.P., Lifupa Lodge, 13 °05' 12 "S 33 °08' 17 "E, h 1035 m, 22.04. 2011, leg. R. Yakovlev (RYB).Published as part of Yakovlev, Roman V. & Murphy, Raymond J., 2013, The Cossidae (Lepidoptera) of Malawi with descriptions of two new species, pp. 371-393 in Zootaxa 3709 (4) on page 390, DOI: 10.11646/zootaxa.3709.4.5, http://zenodo.org/record/24896
C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins
No full textThe human DNA mismatch repair (MMR) process is crucial to maintain the integrity of the genome and requires many different proteins which interact perfectly and coordinated. Germline mutations in MMR genes are responsible for the development of the hereditary form of colorectal cancer called Lynch syndrome. Various mutations mainly in two MMR proteins, MLH1 and MSH2, have been identified so far, whereas 55% are detected within MLH1, the essential component of the heterodimer MutLα (MLH1 and PMS2). Most of those MLH1 variants are pathogenic but the relevance of missense mutations often remains unclear. Many different recombinant systems are applied to filter out disease-associated proteins whereby fluorescent tagged proteins are frequently used. However, dye labeling might have deleterious effects on MutLα's functionality. Therefore, we analyzed the consequences of N- and C-terminal fluorescent labeling on expression level, cellular localization and MMR activity of MutLα. Besides significant influence of GFP- or Red-fusion on protein expression we detected incorrect shuttling of single expressed C-terminal GFP-tagged PMS2 into the nucleus and found that C-terminal dye labeling impaired MMR function of MutLα. In contrast, N-terminal tagged MutLαs retained correct functionality and can be recommended both for the analysis of cellular localization and MMR efficiency
Was ist ein geeigneter Maßstab, um die Ergebnisse von Lokalisationsergebnissen interpretieren zu können?
No full textHintergrund: Das Richtungshören ist eine der Grundfunktionen des binauralen Hörens. Durch einen Vergleich der beidohrigen Signale, kann der Ort eines Hörereignisses bezüglich Richtung und Entfernung bestimmt werden. In verschiedenen Alltagssituationen ist die präzise Ortung von Schallquellen von großer Bedeutung. Neben der Ortung von möglichen Gefahrenquellen, spielt die Lokalisationsfähigkeit auch bei der Kommunikation eine grundlegende Rolle. So ist die Lokalisation eines Sprechers für das Verstehen von Sprache im Störgeräusch entscheidend. Im Vergleich zu Normalhörenden, zeigen Patienten mit Hörstörungen zum Teil erhebliche Defizite beim Richtungshören. Trotzdem ist die Überprüfung der Lokalisationsleistung bisher nicht flächendeckend im klinisch-audiologischen Bereich vertreten. In Forschungslaboren gibt es viele unterschiedliche Messmethoden, die jedoch nicht in der Diagnostik und Rehabilitation eingesetzt werden. Ferner ist auch die Darstellung und Auswertung der Ergebnisse entscheidend für die Begutachtung und Interpretation der jeweiligen Lokalisationsleistungen. Gleichwohl wäre eine Analysemethode wünschenswert, die etwaige Faktoren der unterschiedlichen Messsysteme berücksichtigt und die Berechnung eines geeigneten Indexes zulässt.Material und Methoden: Die Messungen finden an einem modifizierten Mainzer Kindertisch (ERKI-Setup, Plotz & Schmidt ) statt. Im Bereich von ±90° werden die Stimuli (300 ms; 65 dB SPL) in 5°-Schritten über 37 Wiedergabewinkel (5 reale, 32 virtuelle Schallquellen) präsentiert. An der Studie nahmen normalhörende Kinder, sowie normalhörende und schwerhörende Erwachsene teil.Ergebnisse: Für den Tagungsbeitrag werden die Ergebnisse aus den ERKI-Messungen mit verschiedenen Analysemethoden ausgewertet und zueinander in Bezug gesetzt. Ein Ansatz ist, neben dem RMS-Wert bzw. den RMS-Fehler auch den "localization sensitivity index (LSI)" nach der Methode von Zheng et al. zu berechnen. Die Arbeitsgruppe von Zheng kritisierte in ihrer Studie die Aussagekraft des RMS-Wertes bezogen auf die Lokalisationsfähigkeit des Probanden. So erhielten sie z.B. für zwei Probanden sehr ähnliche RMS-Werte, obwohl die Muster der Lokalisationen unterschiedlich waren. Zudem gab es erste erfolgreiche Ansätze, die Ergebnisse der Lokalisationsexperimente über antrainierte Algorithmen auszuwerten (Lückehe et al. ). Der Algorithmus sollte entscheiden, ob es sich bei den ERKI-Ergebnissen um die eines Kindes oder eines Erwachsenen handelte
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
Intern experience at CH���M Hill, Inc.: an internship report
No full textIncludes author's vita"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirement for the degree of Doctor of Engineering."Includes bibliographical referencesA review of the author's internship experience with CH���M HILL, Inc.
during the period September 1975 through May 1976 is presented. During this nine month
internship the author worked as an Engineer II in the Industrial Processes discipline of this
large consulting engineering firm... The author's prime responsibility was as one of three
lead design engineers on the design of a large wastewater treatment facility for a pulp mill
in Hoquiam, Washington owned by ITT Rayonier Inc. The work generally consisted of the design
of individual treatment units and associated piping and pumping. The purpose of the project
was to provide wastewater treatment capabilities that would satisfy the effluent limitations
(standards) imposed upon the mill by the State of Washington Department of Ecology and the
U.S. Environmental Protection Agency. The author's assignment also entailed necessary
interaction with the project manager and other CH���M HILL design engineers and support staff
members, the client's representatives, and representatives of two other consulting engineering
firms working on the project. Thus, the internship position at CH���M HILL provided considerable
experience coordinating the author's work with the work of other engineers, guiding the design
and administrative efforts of a support staff, and interacting regularly with the client and
other consulting firms. This broad exposure to a variety of engineering and organizational
problems provided a valuable educational experience
Intraspecific allometric comparison of laboratory gerbils with Mongolian gerbils trapped in the wild indicates domestication in Meriones unguiculatus (Milne-Edwards, 1867) (Rodentia : Gerbillinae)
No full textA survey of adult male Mongolian gerbils, Meriones unguiculatus (Milne-Edwards, 1867), either trapped during an expedition in Mongolia near 47 degreesN and 105,5 degreesE in June 1995 (WILD) or obtained from a laboratory strain bred in captivity since 1935 (LAB), revealed significant morphological and behavioural differences, which are likely a result of domestication in the laboratory strain. Mean body length (125.4 mm), tail length (95.5 mm) and body weight (53.6 g) was lower in WILD, although no other external characteristics were obviously different. Related allometrically to net carcass weight, organ weights were significantly lower (p < 0.01) in LAB (brain - 17.6%, eyes - 26.0%, heart - 22.3%, lungs - 43.3%). Seizures frequently seen in LAB were absent in WILD trapped (n = 167) or subsequently housed in Germany (n = 8 1), and rare in their offspring. Mean litter size was greater in LAB (n = 5.5) than in WILD bred in the laboratory (n = 4.4). The WILD breeding strain was named Ugoe:MU95. A genetic bottleneck (n = 9) that occurred in 1954 and remarkably smaller brains in LAB indicate that the laboratory strain has become domesticated and should be designated as "Laboratory gerbils" (M. unguiculatus forma domestica) to signify this new case of domestication among rodents
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