21,103 research outputs found
Characterization of the Potential Antiviral Activity of Peptides and Peptoids against Influenza A Virus and Severe Acute Respiratory Syndrome Coronavirus 2
No full textSevere Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) has caused worldwide panic during 2020. To date SARS-CoV-2, the virus causing COVID-19, has caused 1 million deaths and infected over 35 million people in under 10 months. On the other hand, influenza A virus (IAV) has been responsible for several epidemics and millions of deaths during the last 100 years. Our study joins the race to identify novel COVID-19 treatments by investigating the antiviral capabilities and clinical potential of a series of antimicrobial peptides and peptoids against these two important respiratory viruses. The project aimed to identify potential candidates within a panel of peptides (n=4) and peptoids (n=14) kindly provided by Dr. Daniel Pletzer (University of Otago, New Zealand) and A/Prof Annelise Barron (Stanford University, USA), respectively. Standard drug discovery strategies were employed to determine the ability of the peptides/peptoids to inhibit viral replication (EC50 values), while causing negligible cytotoxicity (CC50 values) in different cell lines. We uncovered 8 peptides/peptoids which showed antiviral activity against IAV (EC50 values ranging from 49 μg/ml to 5.7 ug/ml), as well as 12 antimicrobial peptides/peptoids able to inhibit the replication of SARS-CoV-2 (EC50 values range, 41 μg/ml to 3.2 ug/ml). In summary, promising selectivity index (SI) values warrant continued characterization of the antiviral activity of the novel antimicrobial peptides/peptoids, including but not limited to (i) verifying their specificity by testing other influenza and coronavirus strains and (ii) in vitro selection of viruses with reduced susceptibility to these peptides/peptoids. Our results add to the growing evidence that some antimicrobial peptides and peptoids are also capable of inhibiting viral replication. The need for additional SARS-CoV-2 and IAV treatments is urgent and studies such as this one contribute to essential research against these deadly viruses
Characterization of the Potential Antiviral Activity of Peptides and Peptoids against Influenza A Virus and Severe Acute Respiratory Syndrome Coronavirus 2
No full textSevere Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) has caused worldwide panic during 2020. To date SARS-CoV-2, the virus causing COVID-19, has caused 1 million deaths and infected over 35 million people in under 10 months. On the other hand, influenza A virus (IAV) has been responsible for several epidemics and millions of deaths during the last 100 years. Our study joins the race to identify novel COVID-19 treatments by investigating the antiviral capabilities and clinical potential of a series of antimicrobial peptides and peptoids against these two important respiratory viruses. The project aimed to identify potential candidates within a panel of peptides (n=4) and peptoids (n=14) kindly provided by Dr. Daniel Pletzer (University of Otago, New Zealand) and A/Prof Annelise Barron (Stanford University, USA), respectively. Standard drug discovery strategies were employed to determine the ability of the peptides/peptoids to inhibit viral replication (EC50 values), while causing negligible cytotoxicity (CC50 values) in different cell lines. We uncovered 8 peptides/peptoids which showed antiviral activity against IAV (EC50 values ranging from 49 μg/ml to 5.7 ug/ml), as well as 12 antimicrobial peptides/peptoids able to inhibit the replication of SARS-CoV-2 (EC50 values range, 41 μg/ml to 3.2 ug/ml). In summary, promising selectivity index (SI) values warrant continued characterization of the antiviral activity of the novel antimicrobial peptides/peptoids, including but not limited to (i) verifying their specificity by testing other influenza and coronavirus strains and (ii) in vitro selection of viruses with reduced susceptibility to these peptides/peptoids. Our results add to the growing evidence that some antimicrobial peptides and peptoids are also capable of inhibiting viral replication. The need for additional SARS-CoV-2 and IAV treatments is urgent and studies such as this one contribute to essential research against these deadly viruses
Report on Meteorological Research March 1, 1935 (m-1)
No full textThe object of the report was to elucidate in detail the various features of the research program in meteorology being carried on at the Daniel Guggenheim Airship Institute in Akron, Ohio. Mr. L. J. Fangman, of the U.S. Weather Bureau, was collaborating with the author in carrying out work such as a study of autographic records of the various meteorological elements during frontal passages with a view to the possible prediction of the intensity of the accompanying disturbance as it may affect the operation of aircraft and a study of atmospheric gustiness with a view to finding the dependence between frequency end amplitude of velocity fluctuations and the vertical temperature and velocity gradients
(Fourth) Report on Meteorological Activities at the DGAI (8-1-36)(Weather Bureau Copy)
No full textThis report is on the investigations of frontal phenomena at the Daniel Guggenheim Airship Institute in Akron, Ohio from January 1, 1935 through August 1, 1936. The investigation was carried out with the cooperation of the U.S. Bureau of Aeronautics, the U.S. Weather Bureau, the California Institute of Technology, and the Guggenheim Airship Institute. Mr. R.C. Robinson of the Weather Bureau cooperated with the author in carrying out the investigation. The object of the investigation was to determine the intensity of the atmospheric disturbances (i.e. rapidity of wind shift and gustiness) accompanying the passage of cold fronts, along with a study of the characteristics of the air masses involved and other features which might affect the intensity of the disturbance. The report treated thirty cold fronts which passed the station during 1935 to 1936
Archives and Images as Repositories of Time, Language, and Forms from the Past: A Conversation with Daniel Eisenberg
No full textDaniel Akech
No full textabstract: Daniel was a little boy when the war came to his village. He witnessed people being shot and running for shelter. There was no food or water so he drank urine and ate tree leaves.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 24Region: Upper NileThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
Daniel Emmett postcard
No full textPostcard of Daniel Emmett and his home in Mount Vernon, Ohio. Emmett is considered to be the author of the antebellum song "Dixie," written in 1859, which became the unofficial song of the Confederate soldiers during the American Civil War. He was born in Mount Vernon in 1815 and taught himself the fiddle, and later became associated with minstrel shows and helped to define that genre. Minstrel shows traveled around the United States, presenting skits and musical performances. Emmett also composed many other songs, including "Old Dan Tucker," "Turkey in the Straw," and "The Blue Tail Fly." He died in 1904
Daniel Jau Maper
No full textabstract: Daniel Jau Maper was herding cattle when Arabs attacked his village.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 27Region: Upper NileThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
Daniel A. Ngor
No full textWhen Daniel was five years old Arab soldiers attacked his village.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age : 23Region: Upper NileThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
Personal Papers (MS 80-0002)
No full textLetter from Mary T. Steyn of The Readers Digest to Daniel W. Kempner providing some information on the author of an article he was asking about
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