117 research outputs found
Varvara Stepanova: Incomplete Design History Podcast
No full textVarvara Stepanova was a leader of the constructivist movement and co-author of the constructivist manifesto. Described as “a frenzied artist,” she designed books, magazines, posters, advertisements, as well as textiles, clothing, and costumes. On top of that, she was an author and poet. Her design style and aesthetic was avant garde, modern, and often characterized by simplicity and geometric forms and patterns, but Varvara was never content with stasis. She constantly evolved her style and worked to develop new concepts and ideas. As a co-founder of the Constructivist movement, her work typifies the aesthetic and philosophies of Constructivism. While Varavara worked on many of her own projects, she also did many together with her husband, Alexander Rodchenko, another well-known Constructivist designer. Her work often gets linked to Rodchenko’s, and it’s Rodchenko who gets mentioned in histories of graphic design and credit for designs that should be attributed to Stepanova as well. At a time when women were largely still expected to be no more than wives and mothers, Stepanova was a woman who made an unmistakable mark on art and design.NoUniversity of Central Oklahoma. School of Design
Έκφραση DAZL, OCT4 και Υποδοχέα Ωκυτοκίνης σε καινοτόμα καλλιέργεια αμνιακού υγρού
No full textΤα MSCs (Mesenchymal Stem Cells- Μεσεγχυματικά Βλαστικά κύτταρα) αποτελούν έναν πληθυσμό πολυδύναμων κυττάρων και εμφανίζουν ιδιότητες πολυδυναμίας και αυτοανανέωσης σε επιμέρους ιστούς της μεσεγχυματικής σειράς. Επιπλέον παρουσιάζουν την ικανότητα της in vivo αποκατάστασης του ιστού από τον οποίο προέρχονται. Επομένως τα MSCs αποτελούν μια σημαντική πηγή πολυδύναμων κυττάρων για τη συστηματική εφαρμογή αυτόλογης κυτταρικής και γονιδιακής θεραπείας. Συνεπώς, η μελέτη και ο προσδιορισμός εναλλακτικής πηγής MSCs κρίνεται απαραίτητος. Η παρούσα μελέτη επικεντρώθηκε σε μια καινοτόμο τεχνική καλλιέργειας του AF (Amniotic Fluid- Αμνιακού υγρού), στην οποία ο εμβρυϊκός ορός βοοειδών αντικαθίσταται με ορό αμνιακού υγρού, με σκοπό την ταυτοποίηση, την απομόνωση και τον χαρακτηρισμό κυττάρων AF-ΜSCs like (Amniotic Fluid Stem Cells - Βλαστικά κύτταρα Αμνιακού υγρού). Κύτταρα από ανθρώπινο αμνιακό υγρό καλλιεργήθηκαν και AF-MSCs like ταυτοποιήθηκαν με μικροσκοπία. Τα κύτταρα απομονώθηκαν και στη συνέχεις πραγματοποιήθηκε μοριακός έλεγχος της γονιδιακής έκφρασης των δεικτών πολυδυναμίας Oct-4, DAZL καθώς και του υποδοχέα της ωκυτοκίνης. Η μοριακή ανανάλυση με RT-PCR (Real Time Polymerase Chain Reaction- Αλυσιδωτή Αντίδραση Πολυμεράσης Πραγματικού Χρόνου) έδειξε υψηλή έκφραση του Oct-4 και σημαντική έκφραση του DAZL και του υποδοχέα της ωκυτοκίνης. Η έκφραση του δείκτη πολυδυναμίας Oct-4 υποδεικνύει την παρουσία AF-MSCs κυττάρων κατάλληλων για άμεση χρήση στην αναγεννητική ιατρική λόγω έλλειψης ορού ζωικής προέλευσης. Η έκφραση του δείκτη DAZL υποδηλώνει την παρουσία πληθυσμού κυττάρων παρόμοιων με γεννητικά κύτταρα. Οι υποδοχείς ωκυτοκίνης εκφράζονται σε αρχικά στάδια ανάπτυξης των θηλαστικών, υποδηλώνοντας ότι η ωκυτοκίνη μπορεί να εμπλέκεται στη διαφοροποίηση των βλαστικών κυττάρων σε γενετικές κυτταρικές σειρές σε πρώιμα στάδια ανάπτυξης θηλαστικών.Human mesenchymal stem cells (MSCs) constitute a multipotent cell population and are able to differentiate into various lineages of mesenchymal tissues. Studies have indicated the capability of MSCs for in vitro regeneration of their tissue of origin. It is evident that MSCs play an important role in the systematic application of autologous cell and gene therapy. Amniotic fluid (AF) represents a noncontroversial MSCs source. The present study, focused on an innovative technique of cultured AF, in which fetal bovine serum is replaced with amniotic fluid serum, to achieve the identification, isolation and characterization of AF stem cell like cells. Cells from human amniotic fluid were cultured and AF-MSCs like cells were identified with microscopy. Cells were isolated and analyzed for gene expression of pluripotency markers Oct-4, DAZL and oxytocin receptor. RT-PCR results indicated high expression of Oct-4 and a significant expression of DAZL and oxytocin receptor. The expression of pluripotency marker Oct-4 indicates the presence of AF-MSCs like cells suitable for direct use in regenerative medicine due to the fact of animal origin free serum. DAZL expression indicates the presence of germ cells like cells. Oxytocin receptors are expressed in early mammalian developmental stages, suggesting that oxytocin may be involved in the differentiation of stem cells into the germ cell lines at the very early stages of the mammalian development
3Δ βιοεκτύπωση ενάγγειων οστικών μοσχευμάτων με χρήση σνθρώπινων ενήλικων βλαστοκυττάρων και κυτταρο-καθοδηγητικών βιοϋλικών με μηχανική διέγερση
No full textCurrent medical practice still faces significant challenges in treating large bone defects caused by trauma or disease. The main causes of large graft failure are inner graft necrosis and lack of integration with the host tissue due to poor vascularization. Developing bone grafts that can restore vascular function to the regenerating bone tissue has been the most difficult aspect to address. This thesis explores the critical role of vascularization in enhancing bone tissue engineering outcomes. Acknowledging the potential of 3D bioprinting in bioengineering complex tissues, this study introduces a dual-layered 3D bioprinted vascularized bone model aiming to promote bone regeneration under physiological mechanical loading. The inner layer comprises a vascular-like matrix created from a nanocomposite ink of gellan gum, laponite, and platelet-rich plasma (PRP), with laponite serving as a carrier for the PRP-containing bioactive growth factors, along with Wharton-jelly mesenchymal stem cells. The outer layer features a bone-like matrix containing bone marrow mesenchymal stem cells encapsulated in a photocrosslinkable blend of poly(ethylene glycol) diacrylate (PEGDA), gelatin, and poly(vinyl alcohol). The electrically conductive poly(3,4-ethylenedioxythiophene) (PEDOT) is introduced in the outer layer to enhance the activity of voltage-gated channels, facilitating calcium ion flow across the cell membrane, amplifying the signal triggered by mechanical stimulation. Dynamic cell cultures performed in the presence of mechanical stimulation within a bioreactor were employed to mimic the physiological environment of native bone tissue. The synergistic cellular and molecular interactions of the dual-layered constructs significantly enhance the osteogenic and angiogenic differentiation due to paracrine signaling. Key markers of osteogenesis and angiogenesis showed significant upregulation in response to mechanical stimulation, particularly in the dynamic cultures. The complex bioprinted constructs demonstrated excellent in vitro biocompatibility, without observing any adverse foreign body reaction following in vivo subcutaneous implantation in mice. The mechanoresponsive biofabricated platform has great potential to promote vascularized bone regenerationΗ σύγχρονη ιατρική πρακτική εξακολουθεί να αντιμετωπίζει σημαντικές προκλήσεις στην αντιμετώπιση μεγάλων οστικών ελλειμμάτων που προκαλούνται από τραύματα ή ασθένειες. Οι κύριες αιτίες αποτυχίας μεγάλων μοσχευμάτων είναι η νέκρωση του μοσχεύματος και η έλλειψη ενσωμάτωσης με τον ιστό του ξενιστή λόγω κακής αγγείωσης. Η ανάπτυξη οστικών μοσχευμάτων που μπορούν να αποκαταστήσουν τη λειτουργία των αιμοφόρων αγγείων στον αναγεννώμενο οστικό ιστό αποτελεί τη μεγαλύτερη πρόκληση. Αυτή η διατριβή διερευνά τον κρίσιμο ρόλο της αγγείωσης στη βελτίωση των αποτελεσμάτων της μηχανικής οστικού ιστού. Αναγνωρίζοντας τη δυναμική της τρισδιάστατης βιοεκτύπωσης στη βιομηχανική σύνθετων ιστών, η παρούσα μελέτη παρουσιάζει ένα διστρωματικό τρισδιάστατο βιοεκτυπωμένο αγγειωμένο μοντέλο οστού, το οποίο στοχεύει στην προαγωγή της αναγέννησης του οστού υπό φυσιολογικές μηχανικές φορτίσεις. Το εσωτερικό στρώμα αποτελείται από μία αγγειακή μήτρα, φτιαγμένη από νανοσύνθετο μελάνι αποτελούμενο από κόμμι γκελλάνης, λασπολίτη και πλάσμα πλούσιο σε αιμοπετάλια (PRP), με τον λασπολίτη να λειτουργεί ως φορέας των αυξητικών παραγόντων που περιέχονται στο PRP, μαζί με μεσεγχυματικά βλαστοκύτταρα του ζελέ του Wharton. Το εξωτερικό στρώμα διαθέτει μία μήτρα ομοιάζουσα με οστό, που περιέχει μεσεγχυματικά βλαστοκύτταρα μυελού των οστών, εγκλωβισμένα σε φωτοδιασταυρούμενο μείγμα πολυ(αιθυλενογλυκόλης) διακρυλικού (PEGDA), ζελατίνης και πολυ(αλκοόλης βινυλίου). Το ηλεκτρικά αγώγιμο πολυ(3,4-αιθυλενοδιοξυθειοφαίνιο) (PEDOT) προστίθεται στο εξωτερικό στρώμα για την ενίσχυση της δραστηριότητας των διαύλων που ελέγχονται από την τάση, διευκολύνοντας τη ροή των ιόντων ασβεστίου μέσω της κυτταρικής μεμβράνης και ενισχύοντας το σήμα που προκαλείται από τη μηχανική διέγερση. Οι δυναμικές κυτταροκαλλιέργειες, οι οποίες πραγματοποιήθηκαν παρουσία μηχανικής διέγερσης μέσα σε ένα βιοαντιδραστήρα, χρησιμοποιήθηκαν για να μιμηθούν το φυσιολογικό περιβάλλον του φυσικού οστικού ιστού. Οι συνεργιστικές κυτταρικές και μοριακές αλληλεπιδράσεις των διστρωματικών κατασκευών ενισχύουν σημαντικά τη διαφοροποίηση σε οστεογενή και αγγειογενή κύτταρα λόγω παρακρινικής σηματοδότησης. Σημαντικοί δείκτες της οστεογένεσης και της αγγειογένεσης έδειξαν σημαντική αυξημένη έκφραση σε απόκριση στη μηχανική διέγερση, ιδιαίτερα στις δυναμικές καλλιέργειες. Οι σύνθετες βιοεκτυπωμένες κατασκευές επέδειξαν εξαιρετική βιοσυμβατότητα in vitro, χωρίς να παρατηρηθεί καμία ανεπιθύμητη αντίδραση ξένου σώματος μετά από υποδόρια εμφύτευση σε ποντίκια. Η μηχανοευαίσθητη βιοκατασκευασμένη πλατφόρμα έχει μεγάλο δυναμικό για την προώθηση της αγγειωμένης αναγέννησης οστού
“Urban text” in Lyrics of Varvara Danilova through Pprism of Silver Age Poetry
No full textThe results of the analysis of “urban text” phenomenon in the lyrics of the modern Evenk poetess Varvara Danilova are presented. The relevance of the study is due to the interest of modern literary criticism in the heritage of the indigenous peoples of the North. The novelty of the work is seen in the consideration of the features of the “urban text” creation in the V. Danilova’s lyrics in the projection on the poetic experience of the Silver Age. The theoretical basis was the works of V. N. Toporov, Yu. M. Lotman, S. P. Gurin, N. V. Schmidt, and others. The material for the analysis was the most representative poems of Danilova’s collections: “Only you ...” (1992—1996), “Heavenly Hell” (2005), “Lunar Legend” (2010), containing direct or indirect indications of the presence of “urban” semantics in the title, at the level of motive-shaped structure or in subtext. It was found that the “urban text” in the lyrics of the Evenk poetess is represented both by concrete cultural and historical realities, and by a certain conventional topos, not tied either to time or space. The poets of the Silver Age, belonging to different literary trends, became the creative guidelines for the author. It is proved that V. Danilova created a unique author’s model of the “urban text”, in which symbolist, acmeistic and futuristic poetic experiences and national-cultural vision, conditioned by the ethnic authenticity of the author, were intertwined
Medetera varvara Grichanov & Vikhrev, sp. nov.
No full textMedetera varvara Grichanov & Vikhrev sp. nov. (Figs. 1–6) Type material. Holotype 3: Morocco, near Essaouira, 31.563 ºN 9.714 ºW, sand dune, 29 March 2009, N.Vikhrev (ZMU). Paratypes. 2 ƤƤ with same data as holotype, 28 and 29 March (ZMU). Diagnosis. Medetera varvara is related to Egyptian M. albescens (Parent) which differs from the former by silvery-white frons and face, hind coxa bearing three outer setae and fore tarsus unmodified. Ornamentation of fore legs is unknown for other species of Palearctic Medetera including M. albescens which was published with a rather detailed description. In the Afrotropics, only M. luteoscutata Parent, 1936, has a small apicoventral process on tarsomere 1 and 3 of fore leg. Mainly Pantropical Saccopheronta Becker, 1914, a sister genus (Grichanov 1997 b) or “ aberrans ’ group of Medetera species (Bickel 1985, 1987) includes species with thickened or widened tarsomeres 2 and 3 of male fore leg. The absolute majority of medeterine species of the world fauna have no remarkable fore leg decoration. Description. Male (Fig. 1): Length (mm): body 2.0, wing 2.0/ 0.7, antenna 0.7, hypopygium 0.8. Head: Frons, face, clypeus, palpus and postcranium greenish, evenly and densely dusted greyish-white, so frontoclypeal suture between face and clypeus not distinct. Postocular setae white, somewhat thickened, strongly increasing in length downward. Ventral postcranium shining greenish, with row of long white thickened setae. Frons with pair of strong vertical setae and pair of ocellar setae slightly stronger than verticals. Postverticals absent. Face relatively wide; ratio of height of face to its maximal width to height of clypeus to height of palpus, 15 / 8 / 5 / 5. Antennal segments short, with short white hairs; scape and pedicel orange-brownish, grey dusted at apex; postpedicel black, rounded. Stylus subapical, bare, about 2 times as long as ocellar seta. Proboscis short, black, shining, with white hairs. Thorax: Dark, densely grey dusted; mesonotum with 3 narrow bronze stripes distinct in anterior view. Three pairs of strong black dorsocentral setae, slightly decreasing in size anteriorly. Notopleural setae 2, sutural 1, supraalar 1, all black; 1 white humeral seta. Acrostichals very short, biseriate, white, extending to mesonotal flattening. Several white setulae in front of first dorsocentral and sutural setae. Propleuron with 5 white thickened setae, lower one almost 2 times longer than others. Scutellum with pair of strong black median setae, lateral setae absent. Legs: Yellow, except fore legs whitish-yellow, hind tibia darkened at apex, tarsomeres 4 and 5 and apical part of 2 and 3 of mid and hind legs brownish; mid and hind coxae mostly dark, grey dusted, yellow at apex. Fore coxa with dense brush of long white flattened setae on anterior surface. Fore femur and tibia without setae. Fore tarsomeres 1 to 5 each with pair of small brown apical postero- and anteroventral setulae; tarsomeres 2 to 5 each with pair of very small brown ventral setulae; tarsomeres 2 to 4 slightly flattened laterally; apical 1 / 3 of tarsomere 1 and tarsomeres 2 to 4 with comb of white thickened cilia on dorsal surface (Fig. 3). Mid coxa with dense brush of long thickened white setae on anterior surface; mid trochanter with single white seta on anterior position; mid femur without setae. Mid tibia with pair of antero- and posterodorsals at 1 / 4 and long apicoventral seta, all white. Mid tarsus with four brown apical setae on each segment; basitarsus in apical half with 4–5 short brown setulae, somewhat irregularly placed, but in either antero- or posteroventral positions, tarsomere 2 with 3 such setulae, 3 rd with 2 –3, 4th and 5 th with 2 ones each; all these setulae gradually decreasing in size apically. Hind coxa with single white seta on outer surface; hind femur with row of white dorsal setulae in basal half; hind tibia slightly thickened at apex, with posterodorsal setula at 1 / 4 and ventral apical one, both white; with very short black posterodorsal apical spur; hind tibia on apical 2 / 3, basitarsus and tarsomere 2 on basal 2 / 3 with row of short dense white posteroventral cilia; hind basitarsus short, with 2 apicals: brown anteroventral and white ventral, with small white posteroventral basal tooth and shallow basal excavation; tarsomeres 2 to 5 each with 1–3 brown anteroventral and 2–3 brown apical setulae, these setulae gradually decreasing in size apically. Fore leg length ratio (from coxa to tarsomere 5): 24 / 40 / 35 / 20 / 10 / 8 / 5 / 5, mid leg: 16 / 42 / 45 / 22 / 10 / 8 / 6 / 5, hind leg: 14 / 45 / 51 / 12 / 24 / 14 / 8 / 6. Wings: Hyaline, veins yellow in anterobasal quarter of wing, brown in other parts (Fig. 4). Costa without long hairs. R 1 short, extending to basal third of wing, R 4 + 5 and M 1 + 2 distinctly convergent at apex. Ratio of part of costa between R 2 + 3 and R 4 + 5 to this between R 4 + 5 and M 1 +2, 25/ 5. Ratio of apical to basal part of M 1 +2, 17/ 18. Ratio of cross-vein m-cu to maximal distance between R 4 + 5 and M 1 + 2 to distal part of CuA1, 10/ 11 / 12. Calypter yellow, with white cilia. Halter yellow. Abdomen: Covered with short white setulae, olive-grey dusted, with fore margin of tergites 3 to 5 bronze dorsally; posterior margin of tergite 1 with 5–6 white flattened setae on each side. Tergite 6 slightly longer than tergite 5; segment 7 longer than preceding, with short hairs; segment 8 large, left basolateral, shorthaired. Epandrium (Fig. 5) black, elongate-triangular; hypandrium basoventral, slightly swollen at base, then thinned, pointed at apex; phallus simple, pointed; epandrial lobe small, hardly divided, bearing pair of long simple setae; surstylus and cercus (Fig. 6) dark-brown; cercus fused almost to apex, covered with short white hairs. Female (Fig. 2): Length (mm): body 2.2, wing 2.2; similar to male except lacking male secondary sexual characters. Each hemitergite bearing 1 acanthophorite and 1 simple seta; acanthophorites thin, much longer than cercus; cercus small, with short hairs. Dense brush of thickened white setae on anterior surface of fore and hind coxae, but setae about two times shorter and more equal in length than those of male. Fore tarsi unmodified; tarsomeres 4 and 5 and apical part of 2 and 3 of fore legs brownish, as on mid and hind tarsi. Hind tibia without apical spur; hind basitarsus simple, without basal tooth. Distribution: Morocco. Etymology. The species is named for Varvara Vikhreva who kindly helped to collect flies in Morocco. Habitat: All three specimens of the type series were collected from sandy substrates. This habitat is rather unusual for mainly dendrophilous, sometimes petrophilous species of Medetera, although many species of the Nearctic M. petulca group occur in such habitats (Bickel pers. comm. 2009). Trees on sand dunes were also examined, but all specimens of tree trunk Medetera (M. flavipes Meigen, 1824, and M. pallipes (Zetterstedt, 1843)) collected on the Essaouira dunes (between 24 and 29 March) belong to other species groups of the genus. The senior author observed M. pallidior imagos in Southern Tajikistan (the Tigrovaya Balka Nature Reserve) in July 1978, where they populated rodent holes (to 5 cm in diameter) on a rather dry and flat semidesert plot not far from the border with a large area of riparian marshes. Males and females of the species concentrated around holes, and frightened or disturbed flies dropped immediately into the holes.Published as part of Ya, Igor & Vikhrev, Nikita E., 2009, Mediterranean species of the Medetera plumbella species group with description of a new peculiar species from Morocco (Diptera: Dolichopodidae), pp. 46-52 in Zootaxa 2170 on pages 48-51, DOI: 10.5281/zenodo.18920
Teatral'nost' v tvorčestve O. I. Senkovskogo
No full textThe present study is dedicated to O. I. Senkovsky, (1800-1858) who was a professor of St. Petersburg University, an outstanding scientist, editor-in-chief of a popular magazine “Reading Library”, an influential literary critic, and a writer. This study provides a novel perspective on Senkovsky’s legacy, an attempt to comprehend his works through theatrical methods.Senkovsky’s literary masks express theatricality in his works. The name of his most famous pseudonym Baron Brambeus borrows deliberately from the Russian “lubok” literature in order to attract the attention of a general reader. It is Senkovsky’s bent for exotics, parody and paradox as the methods for his work that has defined the appearance of such pen-names as Baron Brambeus and others. The study analyses Senkovsky’s outlook on dramatic art and the theatre conception developed by him along with the requirements of theatre staging. The first volume of the “Reading Library” published an article by Senkovsky where he gives an overwhelmingly positive review of Griboedov’s comedy “Woe from Wit”. Also Senkovsky’s critical works were affected by his theatrical methods. In Senkovsky's view, the Russian historical novel needed by no means to bean imitation of Western authors’ style. This concept of the Russian historical romance discovered by Zagoskin appeared to be in opposition to the concept of original Russian fiction. Baron Brambeus himself was a typical representative of the latter. The fabulous revelations of Baron Brambeus are very diverse and refined. Also his approach to Christian and Slavic demonology is completely different from that of his contemporaries’. “Satan’s Great Appearance” is composed totally on theatrical traditions where the author is to be found both as a spectator and as a participant in this “show”. In his later novel “Notes of the House-spirit” Senkovsky returned to this method again. Analysing Senkovsky’s theatre of love and death, the author investigates both his early works such as “A Woman’s Whole Life in a Few Hours” and his later works such as “The Turkish Gipsy”, and “Dreams of Love and Death”, in which the concept of theatre is expressed not as devilish pranks but as a special literary game of mystery that is defined by the novel’s genre and subject-matter.Neuvostoaikana vanhaa venäläistä kirjallisuutta julkaistiin ja luettiin vain soveltuvin osin. Laajalevikkinen yleisöön menevä teksti unohdettiin helposti. Näin kävi myös kirjailija ja lehtimies Osip Senkovskille (1800-1858), joka julistettiin taantumukselliseksi ja unohdettiin. Varvara Fomitsheva tarkastelee väitöskirjassaan Osip Senkovskin tuotantoa ja pyrkii ymmärtämään hänen teoksiaan niissä käytettyjen teatraalisten keinojen näkökulmasta. Uusi venäläinen kirjallisuuden tutkimus pyrkii paitsi kirjailijoiden maineen palauttamiseen myös kirjallisen elämän todenmukaiseen hahmottamiseen.unknown accessibilityei tietoa saavutettavuudest
Academic Achievement in Conjunction with Defense Mechanisms and the Level of Intellectual Development in High School Students
No full textAbstractThis article investigates the problem of interrelationship between schoolchildren's academic performance and their defense mechanisms. The article describes the author's diagnostic method of defense mechanisms and shows the sphere of its application, which is the diagnostics of high school students’ defense mechanisms. The author analyzes the relationship between schoolchildren's academic performance, their defense mechanisms and intellectual development, which may cause learning resistance. Defense mechanisms originate and develop in early childhood; therefore the problem requires further investigation
Minimally Invasive Tryroidectomy: Alternative Surgical Techniques
No full text<p><strong>Abstract:</strong> Traditional thyroid and parathyroid surgeries have conventionally been conducted through a cervical incision, exposing the thyroid gland. Despite the safety and low complication rates associated with experienced surgeons, some patients are left with noticeable neck scars. Recent technological advancements have enabled surgeons to perform thyroid removal from distant locations, thus avoiding visible neck scars. </p><p>Τhe minimally invasive video-assisted technique introduced by Miccoli et al. is the most commonly employed. However, advancements have led to the emergence of innovative approaches that eliminate the need for neck scars. These include the endoscopic and robotic transaxillary retroauricular and transoral approaches, which have demonstrated safety and effectiveness across diverse international populations.</p><p>This article provides an overview of these surgical techniques to help inform surgeons about the surgical procedures of these new minimally invasive thyroid approaches.</p><p><strong>Keywords:</strong> thyroidectomy, minimally invasive surgery, video-assisted surgery, endoscopic surgery, robotic surgery.</p><p><strong>Title:</strong> Minimally Invasive Tryroidectomy: Alternative Surgical Techniques</p><p><strong>Author:</strong> Varvara Kotsi</p><p><strong>International Journal of Novel Research in Healthcare and Nursing</strong></p><p><strong>ISSN 2394-7330</strong></p><p><strong>Vol. 10, Issue 3, September 2023 - December 2023</strong></p><p><strong>Page No: 278-281</strong></p><p><strong>Novelty Journals</strong></p><p><strong>Website: www.noveltyjournals.com</strong></p><p><strong>Published Date: 14-November-2023</strong></p><p><strong>DOI: </strong><a href="https://doi.org/10.5281/zenodo.10124837"><strong>https://doi.org/10.5281/zenodo.10124837</strong></a></p><p><strong>Paper Download Link (Source)</strong></p><p><a href="https://www.noveltyjournals.com/upload/paper/Minimally%20Invasive%20Tryroidectomy-14112023-5.pdf"><strong>https://www.noveltyjournals.com/upload/paper/Minimally%20Invasive%20Tryroidectomy-14112023-5.pdf</strong></a></p>
Ruska emigrantka Varvara Višnjevska/ Višnevskaja v Mariboru leta 1932: nemška vohunka, sovjetska provokatorka, komunistična aktivistka ali mladostna avanturistka?
No full textThe author outlines Varvara Vishnyevska’s mental and emotional state that can be deduced from the criminal fi le of the Maribor district court. Having arrived in Maribor in late 1932, this young Russian emigrant shook the provincial city when her actions aroused the suspicion that she was a communist and a spy. This belief stemmed from a tighter control of the communist activities in the Kingdom of Yugoslavia after the introduction of the 6 January Dictatorship. The author argues that the cultural and historical background of the dismissed criminal case that illustrates the Russian emigrants’ broken identity and demonstrates the mindset of the young European post-war generation, a part of whom lost their collective identity footholds after the disintegration of the (Austro-Hungarian and Russian) empires and, with the onset of the global economic crisis, clung to romantic adventurism. As a well-organized and, after the October Revolution, a notorious and persecuted political activity in European states, to the young generation communism appeared as a suitable phantasm, a refuge.Avtorica se v razpravi posveča obrisom miselnih in čustvenih stanj Varvare Višnjevske, kakor jih je bilo mogoče sestaviti iz kazenskega spisa okrožnega sodišča v Mariboru. Mlada ruska emigrantka je s prihodom v Maribor ob koncu leta 1932 zatresla ustaljeni ritem provincialnega mesta, ko je s svojim ravnanjem vzbudila sum, da je komunistka in vohunka. Takšno sklepanje je bilo posledica poostrenega nadzora nad komunistično dejavnostjo v Kraljevini Jugoslaviji po nastopu šestojanuarske diktature. Kot ugotavlja avtorica, pa kulturnozgodovinsko ozadje padlega kazenskega primera, ki prepričljivo ilustrira identitetni zlom ruskih emigrantov, obenem nakazuje tudi miselnost mlade evropske povojne generacije, katere del se je z izgubo kolektivnih identitetnih oprijemališč po razpadu imperijev (avstroogrskega in ruskega) ter z nastopom svetovne gospodarske krize oprijel romantičnega avanturizma. Komunizem kot odlično organizirana in po oktobrski revoluciji v evropskih državah razvpita in preganjana politična dejavnost se je zdel ustrezna fantazma – zatočišče generacije
A Doubly Fmoc-Protected Aspartic Acid Self-Assembles into Hydrogels Suitable for Bone Tissue Engineering
No full textHydrogels have been used as scaffolds for biomineralization in tissue engineering and regenerative medicine for the repair and treatment of many tissue types. In the present work, we studied an amino acid-based material that is attached to protecting groups and self-assembles into biocompatible and stable nanostructures that are suitable for tissue engineering applications. Specifically, the doubly protected aspartic residue (Asp) with fluorenyl methoxycarbonyl (Fmoc) protecting groups have been shown to lead to the formation of well-ordered fibrous structures. Many amino acids and small peptides which are modified with protecting groups display relatively fast self-assembly and exhibit remarkable physicochemical properties leading to three-dimensional (3D) networks, the trapping of solvent molecules, and forming hydrogels. In this study, the self-assembling fibrous structures are targeted toward calcium binding and act as nucleation points for the binding of the available phosphate groups. The cell viability, proliferation, and osteogenic differentiation of pre-osteoblastic cells cultured on the formed hydrogel under various conditions demonstrate that hydrogel formation in CaCl2 and CaCl2-Na2HPO4 solutions lead to calcium ion binding onto the hydrogels and enrichment with phosphate groups, respectively, rendering these mechanically stable hydrogels osteoinductive scaffolds for bone tissue engineering
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