1,720,971 research outputs found
Implication of death receptor antagonists in neuroblastoma. Role of lifeguard
No full textEl
neuroblastoma
(NBL)
es
el
tumor
sólido
más
común
en
la
infancia
y
representa
un
10%
de
todas
las
muertes
pediátricas
por
cáncer.
Existen
varios
factores
de
riesgo
que
predicen
el
alcance
de
la
enfermedad,
tales
como
la
edad
en
el
momento
del
diagnóstico,
el
estadio,
alteraciones
cromosómicas
y
la
amplificación
del
oncogén
MYCN,
que
caracteriza
el
grupo
de
NBLs
más
agresivos
con
una
probabilidad
de
supervivencia
inferior
al
30%.
En
general,
los
tumores
MYCN
amplificados
desarrollan
resistencia
a
todas
las
modalidades
de
tratamiento
y
muestran
una
alta
capacidad
metastática.
Estas
propiedades
han
sido
atribuidas
a
alteraciones
en
la
maquinaria
apoptótica,
ya
sea
por
silenciamiento
de
componentes
de
la
vía
extrínseca
(como
caspasa-‐8)
o
por
sobreexpresión
de
reguladores
anti-‐apoptóticos
(como
BCL-‐2,
MCL-‐1
o
c-‐
FLIP).
Hasta
hoy
se
sabe
muy
poco
de
la
implicación
de
los
receptores
de
muerte
y
sus
antagonistas
en
NBL.
En
esta
tesis
se
analizaron
los
niveles
de
expresión
de
varios
antagonistas
de
receptores
de
muerte
en
múltiples
bases
de
datos
de
NBL
humano.
Nuestro
trabajo
muestra
que
la
expresión
de
Lifeguard
(LFG/FAIM2/NMP35)
se
ve
disminuida
en
los
tumores
más
agresivos
y
que
bajos
niveles
de
LFG
correlacionan
con
una
peor
supervivencia
del
paciente.
Curiosamente,
aunque
LFG
fue
inicialmente
caracterizada
como
una
proteína
anti-‐
apoptótica,
nosotros
describimos
una
nueva
asociación
de
esta
proteína
con
la
diferenciación
del
NBL.
Asimismo,
la
represión
de
LFG
resultó
en
una
reducción
de
la
adhesión
celular,
una
mayor
habilidad
de
formar
de
esferas
y
un
aumento
en
la
capacidad
de
migración
de
las
células,
confiriéndoles
una
mayor
capacidad
metastática
que
pudo
ser
confirmada
en
experimentos
in
vivo.
Además,
descubrimos
que
la
expresión
de
LFG
estaba
directamente
reprimida
por
MYCN
a
nivel
transcripcional.
Por
tanto,
nuestros
datos
respaldan
una
nueva
función
para
una
diana
de
MYCN
antes
desconocida
y
proporcionan
una
nueva
conexión
entre
la
sobreexpresión
de
MYCN
y
la
mayor
capacidad
metastática
del
NBL.Neuroblastoma
(NBL)
is
the
most
common
solid
tumor
in
infants
and
accounts
for
10%
of
all
pediatric
cancer
deaths.
Several
risk
factors
predict
NBL
outcome,
such
as
age
at
time
of
diagnosis,
stage,
chromosome
alterations,
and
amplification
of
the
oncogene
MYCN,
which
characterizes
the
subset
of
the
most
aggressive
neuroblastomas
with
an
overall
survival
below
30%.
MYCN-‐amplified
tumors
develop
resistance
against
all
treatment
modalities
and
show
a
high
metastatic
capacity.
These
properties
have
been
linked
to
alterations
in
the
apoptotic
machinery,
either
by
silencing
components
of
the
extrinsic
apoptotic
pathway
(e.g.
caspase-‐8)
or
by
overexpression
of
anti-‐apoptotic
regulators
(e.g.
BCL-‐2,
MCL-‐1
or
c-‐FLIP).
Very
little
is
known
on
the
implication
of
death
receptors
and
their
antagonists
in
NBL.
In
this
thesis,
the
expression
levels
of
several
death
receptor
antagonists
were
analyzed
in
multiple
human
NBL
data
sets.
We
report
that
Lifeguard
(LFG/FAIM2/NMP35)
is
downregulated
in
the
most
aggressive
tumors
and
that
low
LFG
levels
correlate
with
poor
patient
survival.
Intriguingly,
although
LFG
has
been
initially
characterized
as
an
anti-‐apoptotic
protein,
we
have
found
a
new
association
with
NBL
differentiation.
Moreover,
LFG
repression
resulted
in
reduced
cell
adhesion,
increased
sphere
growth
and
enhanced
migration,
thus
conferring
a
higher
metastatic
capacity
to
NBL
cells
that
was
confirmed
in
vivo.
Furthermore,
LFG
expression
was
found
to
be
directly
repressed
by
MYCN
at
the
transcriptional
level.
Our
data,
which
support
a
new
functional
role
for
a
hitherto
undiscovered
MYCN
target,
provide
a
new
link
between
MYCN
overexpression
and
increased
NBL
metastatic
properties
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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