1,721,007 research outputs found
Taiwanese composers and piano works in the XX century: traditional Chinese culture and the Taiwan Xin Yinyue
No full textPiano music can be considered a
main tool for understanding the evolution of XX century Taiwanese
New Music. Starting from the first generation of Taiwanese
composers and on the basis of their piano works, the meaning of "xin
yinyue" has been analysed, identifying the
influences of both so-called "traditional culture" and western music in
the development of the new music written by the subsequent
generations of composers. The role of Xuanyin yaji (Atelier de creation
musicale "Formusica") in the spreading of new piano works in the 90s
will be also taken into consideration, as it allows us to draw out an
outline of present-day piano music trends in Taiwan
Il fiume Danshui nella storia e nella letteratura
No full textIl fiume Danshui (Tamsui), insieme al suo ramificato sistema di affluenti, non costituisce soltanto il più importante reticolo idrografico nella zona settentrionale di Taiwan, ma è sin da tempi remoti una delle principali culle della civilizzazione dell’isola. Nonostante la ricca eterogeneità del paesaggio che caratterizza il fiume Danshui dalla foce fino ai suoi più lontani tributari, è tuttavia possibile individuare delle immagini che presentano talora una certa ricorsività fissandosi nell’immaginario collettivo, sottoponendosi a successive rielaborazioni e rievocazioni all’interno di differenti tessuti narrativi di autori che hanno vissuto immersi all’interno di quest’ambiente. Questo intervento intende soffermarsi su alcune di queste prime rappresentazioni del fiume Danshui e del suo variegato paesaggio come riflesso della complessa sensibilità dei narratori che lo hanno rappresentato
Rewriting Memories: Glimpses on the Literary Descriptions of Taipei’s “City South” (Chengnan)
No full textThe literary representation of space allows us to understand the landscape not just as a reality external to the narrating subject but as a network of symbols whose deep values and meanings give life to an aesthetic experience. Consequently, the identity of the landscape is not a univocal concept but it stems from the interpretation of the multiple cultural indicators attributed to it. Within the Taiwanese literature, a central field of research aims highlighting and examining literary landscapes as background of literary works. The urban space of Taipei is certainly one of the privileged places, to the point of being today considered an autonomous research topic as Taipeiology. This essay wish to retrace the representation and imagery related to a specified context of Taipei, the so-called “city south” (chengnan), making the reader as a flâneur between spaces and places of the literary texts
袁桷作品对琴史的综体贡献
No full textYuan Jue (1266-1327), courtesy name Bochang, pseudonym Qing Rong Jushi (Retired Scholar of Refined Demeanor), was one of the most distinguished scholars during Yuan dynasty, his biography record can be found in the 172nd chapter of the official biographies in the History of Yuan Dynasty. To understand Yuan Jue’s knowledge of Qin, is possible to refer to some of his works concerning different aspects of Qin tablatures, schools, masters of the Northern and Southern Song periods. Yuan Jue makes some special remarks on the original source of some melodies played during his own time, pointing out the effective contributions of some of the most relevant Qin masters during Southern Song Dynasty in the formation of the so-called Zhe School, underlining his doubts and believes, especially over master Yang Zuan, the author the Zi Xia Dong tablatures (now lost). According to Yuan Jue, some of the melodies collected in the Zi Xia Dong where not made Yang Zuan himself: after some comparisons, he discovered that the Cai Shi wunong (Five melodies by Cai [Yong]) were mostly identical to the same tablature transmitted by Zhang Yan from Southern Song Dynasty. The famous Qin player Guo Chuwang has been a hanger-on of Zhang Yan’s household; after receiving the tablatures collected by Zhang himself, he underwent a further reassembling and passed them down to later generations, till Yuan Jue’s days. Yuan Jue displays deep respect towards Zhang Yan and Guo Chuwang contributions (Yuan Jue also wrote two poems on Qin melodies written by Guo Chuwang), and the main aim of his texts on Qin is evidently to clarify and attest the real importance and influence of his past masters
River of Darkness: Danshui Representations from Colonial to Post-colonial Taiwan
No full textThe Danshui river, together with its branched tributary system, constitutes the most
important hydrographic network in the northern part of Taiwan, one of the main cradles of civilization on the island since ancient times. Its peculiar ecosystem has been an essential source of livelihood for the Aboriginal groups settled along its course, the main access route for the earliest Spanish and Dutch colonial powers since the seventeenth century, as well as commercial harbour for the mainland Chinese who began to exploit the resources of the territory, developing the first urban settlements in the area later known as the capital Taipei. This paper is focused on the literary representations of the Danshui river during a crucial historical period, the transition from the last years of the Japanese rule over the island to the first stage of the post-colonial epoch. The Danshui river area was formerly known as one of the busiest places of the island but after the arrival of the Japanese in 1895, and in a relatively short period of time, the Danshui river was almost abandoned. Then landscape around the river became the reflection of the feeling of the age, displaying the complex sensitivity of authors such as Lü Heruo and Tao Jingsun representing their disillusion and disenchant soon after the beginning of the post-colonial period, culminating in the tragic events of the 28 th February Incident
The multifaceted role of chemistry to success RNA therapeutics: from photoremovable protecting groups to modified nucleosides
No full textTherapeutic oligonucleotides (TOs) hold substantial potential for precise cancer treatment by modulating cellular pathways;
however, effective delivery to cancer cells and their inner stability in physiological environments remain significant challenges. Chemical modifications play a pivotal role in
overcoming biological barriers and enhancing the pharmacokinetic and pharmacodynamic properties of TOs.
This Ph.D. thesis focuses on two main topics and is divided into two sections (Part A and Part B).
In part A, a modular quinoline-based photolabile protective group was designed and synthesized to allow the caging of
therapeutic oligonucleotides, increasing their stability while spatial-temporal control over their release. We optimised an efficient synthetic strategy for a quinoline-based
photocaging compound consisting of a two-photon excitable system (2PE). Two synthetic strategies were developed: a linear approach and a convergent one. The linear strategy was initially designed to characterize the final compound and 6 conduct bioconjugation trials, while the convergent strategy became necessary to find a more efficient method to produce the final compound in sufficient quantities, which was crucial for the caging purposes.Based on a quinoline moiety, this system can cage hypermodified therapeutic RNAs, such as
small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs), enabling controlled release upon activation. Furthermore, the potential for tissue selectivity within our modular system will be explored through the covalent linkage of the quinoline scaffold to a thiol-selective targeting unit, such as an antibody. Nucleosides and their corresponding phosphate forms (nucleotides) are the
building blocks of nucleic acids and are implicated in all biological functions of cellular life, including metabolic regulation, catalysis, and energy transfer. Given their broad and vital roles, the chemistry of these molecular families is a key research area in bioorganic and medicinal chemistry, particularly in nucleic acid chemistry, where there is an increasing demand for more efficient and stable nucleoside analogues. In part B, to enhance the stability and efficacy of our caged oligonucleotides, we developed a novel and more efficient synthetic approach to produce 4'-fluorouridine (F-
uridine), a nucleoside analogue that retains the 2'-hydroxyl(OH) group. The proposed approach scales up the previously
reported synthesis leveraging the strategy to a multi-gram scale, while reducing the number of steps involved, enhancing
its potential applications and increasing the versatility of its production.
This analogue preserves the stereoelectronic properties of 2'-fluorinated compounds while maintaining the functional benefits of the 2'-OH group. Additionally, since the C4'
position is part of the sugar-phosphate backbone and typically interacts with nucleic acid-binding proteins, 4'-fluoro-RNA
emerges as a promising candidate for the development of oligonucleotide therapeutics based on nucleoside analogues.
Ultimately, this innovative approach synergizes optochemical biology strategies with chemical modifications to advance
targeted oligonucleotide-based therapy, offering promising improvements in stability for the clinical translation of RNA-based therapeutics
Mimic expert judgement through automated procedure for selecting rainfall events responsible for shallow landslide: A statistical approach to validation
No full textThis paper proposes an automated method for the selection of rainfall data (duration, D, and cumulated, E), responsible for shallow landslide initiation. The method mimics an expert person identifying D and E from rainfall records through a manual procedure whose rules are applied according to her/his judgement. The comparison between the two methods is based on 300 D- E pairs drawn from temporal rainfall data series recorded in a 30 days time-lag before the landslide occurrence. Statistical tests, employed on D and E samples considered both paired and independent values to verify whether they belong to the same population, show that the automated procedure is able to replicate the expert pairs drawn by the expert judgment. Furthermore, a criterion based on cumulated distribution functions (CDFs) is proposed to select the most related D- E pairs to the expert one among the 6 drawn from the coded procedure for tracing the empirical rainfall threshold line
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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