121,943 research outputs found
La scuola miniaturistica di S. Eutizio in Valcastoriana presso Norcia nei secoli X-XII
No full textPirri Pietro. La scuola miniaturistica di S. Eutizio in Valcastoriana presso Norcia nei secoli X-XII. In: Scriptorium, Tome 3 n°1, 1949. pp. 3-10
Densification: Hyaluronan Aggregation in Different Human Organs
No full textHyaluronan (HA) has complex biological roles that have catalyzed clinical interest in sev-eral fields of medicine. In this narrative review, we provide an overview of HA aggregation, also called densification, in human organs. The literature suggests that HA aggregation can occur in the liver, eye, lung, kidney, blood vessel, muscle, fascia, skin, pancreatic cancer and malignant mela-noma. In all these organs, aggregation of HA leads to an increase in extracellular matrix viscosity, causing stiffness and organ dysfunction. Fibrosis, in some of these organs, may also occur as a direct consequence of densification in the long term. Specific imaging evaluation, such dynamic ultraso-nography, elasto-sonography, elasto-MRI and T1ρ MRI can permit early diagnosis to enable the clinician to organize the treatment plan and avoid further progression of the pathology and dys-function
Percutaneous Electrolysis for Musculoskeletal Disorders Management in Rehabilitation Settings: A Systematic Review
No full textBackground: Percutaneous electrolysis (PE) is a minimally invasive procedure that utilizes galvanic current delivered through a needle. PE is increasingly employed for musculoskeletal disorders, despite the scarcity of scientific evidence supporting its use. The aim of this systematic review is to synthesize the existing evidence and explore the applications of PE in rehabilitation. Methods: In line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search was conducted across the PubMed, Web of Science, Scopus, and PEDro databases from inception to July 2025. The search strategy employed the term "Percutaneous Electrolysis" without applying additional filters or time restrictions, ensuring a comprehensive search. Cited references from screened articles were also evaluated for potential inclusion. Studies were included if they met the following criteria: peer-reviewed articles, intervention-based research, relevance to the topic, and publication in English. Results: Of the 181 papers retrieved, 143 were excluded for various reasons, leaving 38 studies. The evidence suggests that PE appears effective in reducing pain and improving function, particularly when combined with exercises such as eccentric training or stretching, though inconsistencies in protocols and patient characteristics, along with unclear mechanisms, show that it warrants further investigation. Conclusions: In conclusion, while PE emerges as a promising therapeutic strategy for musculoskeletal disorders, its full integration into rehabilitation practice necessitates further rigorous research to standardize treatment protocols, elucidate the underlying mechanism, and validate its cost-effectiveness. These steps are essential to establish PE as a robust and evidence-based option within the field of rehabilitation
Chondrotoxicity of Intra-Articular Injection Treatment: A Scoping Review
No full textthe purpose of this scoping review was to identify possible chondrotoxic effects caused by drugs usually used for intra-articular injections. pubmed, scopus, web of science and cochrane were searched. Inclusion criteria required randomized controlled trials written in english that evaluate the toxic effect that damages the cartilage. the literature search resulted in 185 unique articles. 133 full-text articles were screened for inclusion, of which 65 were included. corticosteroids, with the exception of triamcinolone, along with local anaesthetics, potentially excluding ropivacaine and liposomal bupivacaine, and nonsteroidal anti-inflammatory drugs, exhibited insufficient safety profiles to warrant casual use in clinical settings. hyaluronic acid, on the other hand, appears to demonstrate safety while also mitigating risks associated with concurrent compounds, thereby facilitating therapeutic combinations. additionally, there remains a paucity of data regarding platelet-rich plasma, necessitating further evaluation of its potential efficacy and safety. overall, it seems that results are significantly influenced by the dosage and frequency of injections administered, observed in both human and animal studies
Ultrasound Examination of Skin, Fasciae and Subcutaneous Tissue: Optimizing Rehabilitation for Secondary Upper Limb Lymphedema
No full textBackground: Lymphedema represents a frequent cause of disability for patients undergoing oncological treatments and, being a chronic, non-reversible pathology, requires targeted and continuous rehabilitation treatments. To date, the studies available on the use of ultrasound in patients with lymphedema mainly report descriptive data; therefore, with this study, we wanted to describe in a more objective way the typical ultrasound alterations found in these patients, measuring the thickness of the different superficial structures, and defining subcutis echogenicity. Methods: 14 patients affected by secondary lymphedema of the upper limbs were enrolled in this cross-sectional observational study (12 had breast cancer and 2 with melanoma as their primary diagnosis). All patients were classified as stage II according to the ISL classification. Patients were examined between March and July 2023 with a clinical and an ultrasound evaluation. Ultrasound evaluation was performed following a protocol and took into consideration thickness of the cutis, subcutis, superficial and deep fascia, and subcutis echogenicity. Results: The cutis of the affected limbs was thicker in the distal anterior region of the arm and throughout the anterior region of the forearm. The subcutaneous tissue was thicker in the posterior region of the distal arm and throughout the forearm, including the dorsum of the hand and excluding only the proximal posterior region of the forearm. Fascial structures did not demonstrate statistically significant differences in thickness between pathological and healthy limbs, despite undergoing significant changes from a qualitative point of view (loss of the trilaminar skin appearance and the development of anechoic areas due to fluid accumulation around the hyperechoic adipose lobule). A statistically significant difference in the echogenicity of subcutaneous tissue was found at the distal anterior region of the arm and at the entire anterior forearm. Conclusions: High-resolution ultrasound has been confirmed to be a tool capable of supporting the diagnosis of lymphedema and identifying the most compromised regions of the limb. A tailored rehabilitation plan can be developed based on the non-uniform alterations in subcutaneous tissue, where some areas are affected earlier than others. This compartmentalization should be considered in lymphedema staging and management. Ultrasound may provide early detection of these changes, guiding a more precise therapeutic approach
Ultrasound examination avoids tunnel vision: diagnosing a simple/painful (epi)dermal cyst
No full text
Diabetic foot: The role of fasciae, a narrative review
No full textWound healing is an intricate, dynamic process, in which various elements such as hyper-glycemia, neuropathy, blood supply, matrix turnover, wound contraction, and the microbiome all have a role in this “out of tune” diabetic complex symphony, particularly noticeable in the complications of diabetic foot. Recently it was demonstrated that the fasciae have a crucial role in proprio-ception, muscular force transmission, skin vascularization and tropism, and wound healing. Indeed, the fasciae are a dynamic multifaceted meshwork of connective tissue comprised of diverse cells settled down in the extracellular matrix and nervous fibers; each constituent plays a particular role in the fasciae adapting in various ways to the diverse stimuli. This review intends to deepen the discussion on the possible fascial role in diabetic wounds. In diabetes, the thickening of collagen, the fragmentation of elastic fibers, and the changes in glycosaminoglycans, in particular hyaluronan, leads to changes in the stiffness, gliding, and the distribution of force transmission in the fasciae, with cascading repercussions at the cellular and molecular levels, consequently feeding a vicious pathophysiological circle. A clear scientific perception of fascial role from microscopic and macro-scopic points of view can facilitate the identification of appropriate treatment strategies for wounds in diabetes and create new perspectives of treatment
La riproduzione dei beni culturali: tra controllo pubblico e diritto all’immagine
No full textDichiarando illegittimo l’utilizzo a fini commerciali dell’immagine del David di Michelangelo in assenza di specifica autorizzazione, l’ordinanza n. 1910 del Tribunale di Firenze dell’11 aprile 2022 estende il concetto di tutela dei beni culturali, facendovi rientrare anche la tutela della loro immagine, stabilendo
che anche quest’ultima - contribuendo alla pubblica fruizione del bene - concorre allo sviluppo della cultura e alla promozione della conoscenza del patrimonio storico-artistico della Nazione. Il contributo, oltre a ricostruire la normativa che disciplina la possibilità di riprodurre i beni culturali, mette in luce gli elementi di novità dell’ordinanza in esame e ne evidenzia alcuni aspetti critici, soprattutto rispetto all’estensione del controllo nello spazio e nel tempo
Numerical study of the effect of channel aspect ratio on particle focusing in acoustophoretic devices
No full text- …
