391 research outputs found
PİR SULTAN ABDAL’IN ŞİİRLERİNDE TURNA MOTİFİ* TURNA MOTION IN PIR SULTAN ABDAL
No full textIn this study, one of the important building blocks of Turkish literature, which is known in a wide
range of geography, especially in Anatolia, the motive of crane in the poetry of Pir Sultan Abdal
who has been transformed into a legend in the language of the people with its life and personality
is examined. According to the widespread understanding in Anatolia, cranes are seen as the symbol
of purity, abundance, happiness, cleanliness, faith, patience and freedom. For this reason, the crane
motive has an important place in folk tales, folk and divan poetry, folk songs, Alevi-Bektashi beliefs
and literature. Therefore, this bird considered sacred, has become the symbol of the people accepted
in the literature of Alevism-Bektashi, especially Hz. Ali. For about two thousand years, Crane has
ensured communication between the homesickness and the expatriate, representing the most valued
and loved people. In the Hacı Bektaş Veli Velayetnâmesi, the first Muslim Turkish sufi, Ahmed Yesevi, was registered as ’crane frost. Besides, Pir Sultan Abdal, regarded as Great by the Alevi people,
frequently used the crane in his poems. Pir Sultan has been the most researched poet ever among the
“Seven Great Poets”. As it is a very popular poet, it has been found that the ”Pir Sultan Abdal” tradition has been formed in Anatolia and the the pseudonym Pir Sultan was used by at least six poets.
The poet, whose poem was identified in this study is Pir Sultan whose real name was Haydar who was
born in Banaz village of Yıldızeli district in the beginning of 16th century. In this study, the, crane motive found in the poems belonging to Pir Sultan, which was compiled by İbrahim Aslanoğlu and
Cahit Öztelli, was tried to be explained by the characteristics of the 16th century and the Alevi-Bektashi beliefs and rituals
Optimized network based natural language processing approach to reveal disease comorbidities in COVID-19
No full textAbstract A novel virus emerged from Wuhan, China, at the end of 2019 and quickly evolved into a pandemic, significantly impacting various industries, especially healthcare. One critical lesson from COVID-19 is the importance of understanding and predicting underlying comorbidities to better prioritize care and pharmacological therapies. Factors like age, race, and comorbidity history are crucial in determining disease mortality. While clinical data from hospitals and cohorts have led to the identification of these comorbidities, traditional approaches often lack a mechanistic understanding of the connections between them. In response, we utilized a deep learning approach to integrate COVID-19 data with data from other diseases, aiming to detect comorbidities with mechanistic insights. Our modified algorithm in the mpDisNet package, based on word-embedding deep learning techniques, incorporates miRNA expression profiles from SARS-CoV-2 infected cell lines and their target transcription factors. This approach is aligned with the emerging field of network medicine, which seeks to define diseases based on distinct pathomechanisms rather than just phenotypes. The main aim is discovery of possible unknown comorbidities by connecting the diseases by their miRNA mediated regulatory interactions. The algorithm can predict the majority of COVID-19's known comorbidities, as well as several diseases that have yet to be discovered to be comorbid with COVID-19. These potentially comorbid diseases should be investigated further to raise awareness and prevention, as well as informing the comorbidity research for the next possible outbreak
Apoyo sanitario durante la invasión y campaña militar de Antonio Maceo en Pinar del Rio
No full textABSTRACT Introduction: a personality who stood out significantly within Pinar del Río and national society during the War of Independence of 1895-1896 was Major General Antonio Maceo. Much has been written about his military exploits, but there are still aspects that are not well supported historically. On the occasion of a political-ideological day in the provinceSubject: of military health was discussed; the insufficient literatures was the reason for undertaking a research aimed at researching the structure of military health that Maceo supposedly had in Pinar del Río during the military campaign in 1896.Methods: A qualitative, historical, situational, and descriptive research was carried out, using the primary and the secondary sources of information collected. The main sources to obtain the data were found in the History Archive and in the Provincial Library of Pinar del Río of the main historical moments with reference to Antonio Maceo.Development: that were published at that time; which allowed to create geographical, chronological and specific thematic aspects, and state.Conclusions: concerning the doctors that really accompanied him and also had a great performance in the attention of the wounded in the main combats, the number of casualties and deaths in the combat actions, the mentioned blood hospitals and the burials carried out in the province. In the opinion of the author, historical facts are mentioned that are typical from Pinar del Río in that military conflict of Maceo.Introducción: una personalidad que sobresalió de manera significativa dentro de la sociedad pinareña y nacional durante la guerra de independencia de 1895 -1896 fue el Mayor General Antonio Maceo. Mucho se ha escrito sobre sus hazañas militares, pero quedan aspectos que no están bien sustentados históricamente. En ocasión de una jornada política ideológica en la provincia donde se abordaba el tema de la sanidad militar; la insuficiente bibliografía, fue motivo para emprender una investigación.Objetivo: indagar sobre la estructura de Sanidad Militar que suponía tenía Maceo en Pinar del Río durante la Campaña militar durante el año 1896.Métodos: se ha realizado una investigación cualitativa, histórica y situacional, descriptiva, utilizando fuentes primarias y secundarias de recolección de información. Las principales fuentes para la obtención de los datos, se encontraron en el Archivo de Historia y en la Biblioteca Provincial de Pinar del Río.Desarrollo: los principales momentos históricos que sobre Antonio Maceo se publicaron en esa época; lo que permitió conformar con aspectos geográficos, cronológicos y la temática específica.Conclusiones: sobre los médicos que realmente lo acompañaron y tuvieron además gran actuación en la atención de heridos en los combates principales, la cifra de bajas y muertos en las acciones combativas, los hospitales de sangre mencionados y los enterramientos realizados en la provincia. A opinión de los autores se mencionan hechos históricos que le son propios a Pinar del Río en esa contienda militar de Maceo
The environmental education in the students of the specialidad welding in Pinar del Río
No full textThe environmental impact of the welding process during learning in the specialized area as well as the exercise of practice for obtaining working qualification in the labor entity students welding specialty in Pinar del Rio has been of interest to the author of this research. The research is the methodological basis dialectical materialist method. From the results obtained it was concluded the need to train a qualified among others show their professional performance in attitudes towards environmental care worker
Factores de riesgo del intento suicida en adolescentes, Pinar del Río
No full textAn observational, analytical case-control study was carried out with the purpose of identifying the risk factors related to suicide attempt in adolescents in Pinar del Rio municipality from January to June 2009. The target group was comprised of the total population from 10 to 19 years old with suicide attempts; the sample consisted of 36 cases vs. 72 controls, chosen by a matching of 1:2, individual and familial risks factors associated with suicide attempt were analyzed as well. Data were obtained by means of the application of a questionnaire designed by the author of the study, the association between the risk factors and suicide attempt was determined using chi square test and the reason of crossed products ratio by punctual estimation and by confidence intervals; among the main results a significant statistical association to suicide attempt was found and the following risk factors: presence of mental disorders in adolescents (depression), mental retardation, schooling difficulties, involuntary boarding school and history of suicide attempt in other family members.Se realizó un estudio observacional analítico de caso y control, con el objetivo de identificar los factores de riesgo relacionados con el intento suicida en los adolescentes del municipio Pinar del Río, en el período comprendido de enero a junio del 2009. El universo del estudio estuvo constituido por la población de 10 a 19 años con intento suicida, quedando conformada la muestra por 36 casos contra 72 controles, seleccionados por un pareo de 1:2, se analizaron los factores de riesgo individuales y familiares asociados al intento suicida. Los datos se obtuvieron mediante la aplicación de un cuestionario diseñado por la autora de la investigación, se determinó la asociación entre los factores de riesgo y el intento suicida, a través de la prueba de Chi cuadrado y la razón de productos cruzados (OR) con estimación puntual y por intervalos de confianza; entre los principales resultados se encontró asociación estadística significativa al intento suicida, de los siguientes factores de riesgo: la presencia de adolescentes con desordenes mentales como depresión y retraso mental, dificultades escolares e internamiento invo luntario y el antecedente de suicidio por otro miembro del hogar
Aportació al coneixement espeleològic del cap des Pinar a Alcúdia
No full text[eng] We show five unknown cavities. These cavities were explored and topographied by the author for 1980-81. During this time he did the militar service in the Alcúdia base. The cavities are in the militar zone called Cap des Pinar, into the municipal district of Alcúdia (Balears).[fre] Nous montrons cinq cavités inédites, explorées et topographiées par I'auteur dans les années 1980-81. Dans cette époque il fit le service militaire a la base d'Alcúdia. Les cavités se trouvent a la zone militaire de Cap des Pinar, Alcúdia (Balears)
Chromatin modifications of hTERT gene in hTERT-immortalized human mesenchymal stem cells upon exposure to radiation
No full textRegulation of telomerase activity is thought to participate in the cellular response to ionizing radiation. Epigenetic mechanisms play a role in this regulation, as well as other mechanisms such as transcription, phosphorylation, etc. Here, we investigated chromatin modifications in telomerase promoter upon exposure to ionizing radiation in human mesenchymal stem cells (hMSC) and telomerase-immortalized hMSCs (hMSC-telo1) together with a hMSC-telo1 cell line in which TRF2 expression was partially repressed (siTRF2 hMSC-telo1). Histone methylations and acetylations were compared in all cell lines after exposure to various doses of ionizing radiation (0.1, 1, 2.5 and 15 Gy) using chromatin immunoprecipitation assay. hTERT gene was shown to be quickly regulated through H3, H4 acetylations, as well as with H3K4 and H3K9 methylations, following radiation exposure, although the kinetic of hMSC-telo1 cells were different, indicative of the higher radioresistivity of these cells. To the author's surprise, there was an upregulation of endogenous telomerase activity in the hMSC-telo1 cells, even though the cells had already expressed high levels of ectopic hTERT. Our results show that telomerase regulation is one of the primary actions in response to damage and epigenetic factors play a major role in this regulation. Our results also suggested that partial silencing of TRF2 enhances the radiosensitivity of these cells, and endogenous telomerase is upregulated upon radiation, even under ectopic expression of hTERT in these cells
Network Based NLP Approach to Reveal Disease Comorbidities. COVID Case Study
No full textSARS-CoV-2 virus, which caused the pandemic COVID-19 , infects the host cells via ACE2 receptor
protein binding to spike proteins. Viral binding also alters the vascular effects of the ACE/ACE2 ratio,
which results in a number of complications. These complications may have detrimental consequences
on patients with chronic diseases such as diabetes, heart disease, tension-related disorders, and kidney
disease, which already have an unbalanced ratio of ACE/ACE2. Due to this mechanism, COVID-19 is
extremely comorbid, and there may be other comorbidities with yet unidentified etiologies.
In this work, possible comorbidities of COVID-19 examined by a network-based representation of
miRNA-gene-disease interactions to reveal possibly similarly altered mechanisms in between diseases.
The original algorithm was implemented as the mpDisNet package which is a word-embedding based
deep learning technique. Algorithm itself was modified and optimized to increase True-Positive
discovery rate by removal of highly frequent diseases such as cancer and expanding the test data by
manual curation of comorbid diseases. Original approach was also modified by integration of miRNA
expression profiles from SARS-CoV-2 infected cell line and transcription factors regulated by these
miRNAs from related databases.
The main aim this work is discovery of possible unknown comorbidities by connecting the diseases by
their miRNA mediated regulatory interactions. The algorithm can predict the majority of COVID-19's
known comorbidities reported in CDC website with high scores; (Diabetes (0,996), Heart Diseases
(0,989), Schizophrenia (0,994), and Hypertension (0,994)), as well as total of 131 diseases that have yet
to be discovered to be comorbid with COVID-19. These potential comorbid diseases should be
investigated further in order to raise COVID-19 awareness and prevention. Our approach can be used for
informing the comorbidity research for the next possible pandemic outbreak
Pinar, William F., Autobiography, Politics, and Sexuality: Essays in Curriculum Theory, 1972-1992. New York: Peter Lang, 1994.
No full textPresents 15 essays written between 1972 and 1992 by the author which convey the meaning ofautobiography as curriculum
Feasibility of Bolted Connectors in Hybrid FRP-Steel Structures
No full textDue to the low weight and excellent durability of composite materials, Fibre Reinforced Polymer (FRP) decks mounted on steel superstructures are becoming all the more common in engineering practice. Bolted joints are generally used to facilitate connections between an FRP deck and steel girders in road bridges. The connections are subjected to both high magnitude static forces as well as fatigue loading due to overpassing vehicles. With ever increasing traffic on both road and railway bridges, fatigue performance is of critical concern. Bolted FRP joints have been extensively researched in the past under static loading, but less is known about the fatigue and creep behaviour of such joints. Furthermore, little research exists on non-pultruded FRP profiles connected using bolted connections. Therefore, the objective of this research is to investigate connectors’ feasibility by means of static, fatigue and creep experiments on four different types of bolted joints comprising mechanical connectors and injection techniques. The study focuses on application in vacuum infused GFRP panels with integrated webs made of multi-directional laminates, connected to steel bridge superstructures. In addition, experimental results are validated by Finite Element Analyses (FEA). Based on the obtained results, the novel injected steel-reinforced resin (iSRR) connector developed at TU Delft shows promising potential in hybrid steel-FRP bridges where good fatigue endurance of the connection and local loads in FRP panel, are required.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Steel & Composite Structure
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