1,720,955 research outputs found
ZUDY, LA GATTA CON DISURIA: ALLORA E’ UN TIMOMA !
No full textÈ descritto il caso di un timoma diagnosticato in un gatto europeo femmina di 15 anni e 4.5 kg di peso portato alla visita in regime di pronto soccorso per disuria insorta da circa 24 ore. L’esame delle urine dimostrava la presenza di un’infezione urinaria sostenuta da abbondanti batteri coccoidi e filamentosi, pur in assenza di un corrispondente reperto infiammatorio. L’esame ecografico dell’addome non evidenziava alterazioni. Il quadro radiografico ed ecografico del torace evidenziava una massa radiopaca a carico del mediastino cranio-ventrale determinante lo spostamento dorsale della trachea. Sulla base di questi primi riscontri venivano posti in diagnosi differenziale linfoma timico, timoma, chemodectoma, cisti branchiale, tiroide ectopica, tumori delle paratiroidi, granuloma e ascesso. Lo studio TC del torace evidenziava una massa di 3 cm di diametro nel mediastino craniale che improntava il bordo craniale del cuore comprimendo atrio e ventricolo destro. La lesione appariva eterogenea prima e dopo la somministrazione di MDC iodato non ionico a 800 mg/kg e.v. Venivano eseguite biopsie TC guidate con ago sottile 22 G e con tru-cut da sottoporre ad esame citologico ed istopatologico. L’esame citologico (colorazione May Grünwald-Giemsa) evidenziava scarsa cellularità del campione e discreta componente ematica. La popolazione cellulare prevalente era rappresentata da piccoli e medi linfociti, accanto ai quali erano osservabili rari mastociti, macrofagi ed eosinofili, che, pur nell’assenza di una evidente componente epiteliale, orientavano la diagnosi verso il timoma piuttosto che verso una neoplasia linfoide. L’esame istopatologico delle biopsie metteva in evidenza un tessuto discretamente vascolarizzato costituito dalla proliferazione diffusa di piccoli-medi linfociti di aspetto maturo, nel cui contesto si rilevavano occasionali aggregati di cellule irregolarmente poligonali con abbondante citoplasma eosinofilo e granulazioni bluastre, tendenti alla cheratinizzazione e disposte concentricamente a formare strutture simili ai corpuscoli timici di Hassal. Veniva formulata la diagnosi di timoma prevalentemente linfocitico, supportata dalla conferma immunoistochimica della natura epiteliale degli aggregati concentrici (CKAE1/AE3 +) e dal fenotipo T della componente linfoide (CD3 +). Sul riscontro di tale diagnosi, pur in assenza di segni clinici riferibili a myasthenia gravis (debolezza, rigurgito), si procedeva, in vista del probabile intervento chirurgico, a completare la stadiazione con la determinazione del titolo sierico di anticorpi anti-recettori postsinaptici per l’acetilcolina (AChRAb); il titolo anticorpale ottenuto (< 0.30 nmol/L ) permetteva di escludere le complicazioni relative alla sindrome paraneoplastica mio astenica. Gli accertamenti finora condotti permettevano pertanto una diagnosi definitiva di timoma linfocitico, con stadiazione clinica II, sottostadio P0. A distanza di 30 gg dal momento della presentazione si procedeva all’intervento di escissione chirurgica della massa mediastinica. A 2 mesi di distanza veniva effettuato un monitoraggio completo (profilo ematobiochimico, esame urine, radiogramma del torace, esame ecocardiografico) che escludeva qualsiasi complicazione successiva all’intervento. L’interesse del caso presentato risiede nella coesistenza di elementi di tipicità e atipicità. Tra gli ultimi il motivo di presentazione (disuria per infezione urinaria), verosimilmente in relazione allo stato di immunodepressione indotto dalla interferenza tumorale con la funzionalità dei linfociti. Tra i primi, assai più numerosi, l’età avanzata, il decorso cronico e con scarso corredo di sintomi, la struttura macroscopica della massa (capsulata / cavitata), il tipo istologico. Si enfatizza il ruolo della citologia nel fornire un orientamento diagnostico, la correlazione con il sempre necessario esame istopatologico e l’utilità della diagnostica per immagini
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Prognosis following surgical excision in canine and feline malignant skin tumors: the role of the histological evaluation of margins.
No full textWide surgery represents the best therapy for skin tumors, although hampered by local recurrences after incomplete removal. As the clinical assessment of tumor size rarely corresponds to its actual extension, the completeness of surgery can be effectively determined only by the histological evaluation of excision margins.
To assess the efficacy of the histological evaluation of margins in predicting the development of local recurrence, 50 canine and feline surgically-removed skin tumors (21 MCTs, 18 soft tissue sarcomas, 11 carcinomas) have been examined. Margins were judged as clean, clean but close (tumor cells < 2 mm from margins) or infiltrated. Histological grade was assessed in sarcomas and MCTs. Tumor recurrence-free intervals (RFIs) at 1 and 2 years were recorded.
Margins were infiltrated in 19/50 cases (38%), clean but close in 9/50 (18%), and clean in 22/50 (44%). Recurrence occurred in 19 cases. Mean RFI was 233 days (range: 31-661). Recurrence rates were 68.42% (infiltrated margins), 44.44% (clean but close margins), and 9.09% (clean margins). The method accuracy improved with the extension of the follow-up period, and was highest for carcinomas (100%), intermediate for sarcomas (89%) and lower for MCTs (78%), due to actual difficulties in distinguishing if mast cells found on margins are normal or neoplastic.
Histological evaluation of margins is a good predictor for tumor recurrence, although more likely to generate false positives in MCTs. Because of generally long recurrence times, post-surgical surveillance should be extended to at least 2 years. Tumor grade influences RFI but not the method accuracy
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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