1,720,971 research outputs found
Unmet needs in hidradenitis suppurativa: patients' perspective on daily management and cosmetic cares
Full text linkHidradenitis Suppurativa (HS) is a chronic debilitating inflammatory disease, affecting very sensitive areas, such as genitalia, axillae, and groins ofmostly young people, with a female predilection. Signs and symptoms are devastating for patients’ quality of life,
joined with a history of diagnostic delay, and hidden sufferance even to close relatives. The disease has gained an increasing interest, with the proposal of new efficacious medical treatment. Besides, cosmetic skin care is somewhat uncover. To challenge patients’
own perspective, the proposal of a survey to the main Italian Association, named Inversa Onlus, pointed out a free access question naire, published on the website. One hundred fifteen patients listed the major causes of daily activities limitation from a cosmetic point of view, selecting six items: affected skin appearance; scars appearance; smell; perspiration; epilation; blemish dresses. A 5 points scale expressed
the level of disturbance, and the most rated features resulted: skin overall appearance, followed by scars, dirty spots on dress and problems related to depilation, while lesions smell and perspiration problems were judged less important. Asking patients unveiled that physicians should also take care of main accessory, cosmetically oriented daily needs, suggesting dedicated lines of products to improve skin appearance, and social acceptability
Rare emerging malignant skin tumors
No full textAs clinical skills improves and innovative diagnostic techniques become available in the field of dermatology and dermatopathology, new types or additional variants of malignant skin tumors are described. This article reviews the current nomenclature, clinico-pathological features, differential diagnosis, prognostic and therapeutic implications of some new dermato(patho)logical rare emerging skin tumors including epithelial tumors (squamous cell carcinoma with mucinous metaplasia), adnexal tumors (endocrine mucin-producing sweat gland carcinoma), soft tissue tumors of vascular differentiation (pseudolymphomatous cutaneous angiosarcoma, pseudomyogenic hemangioendothelioma), hematopoietic tumors (blastic plasmacytoid dendritic cell neoplasm) and mixed epithelial/melanocytic tumor (squamomelanocytic tumor)
Adverse cutaneous reactions to cardiovascular drugs: the experience of the Department of Dermatology in Cagliari
No full textAim. Adverse drug reactions (ADR) represent a heterogeneous group of diseases, often responsible for admission or complication during hospitalization. Risk of ADR increases in elderly and medicated patients, with a high prevalence of cardiovascular diseases. The aim of this prospective study was to investigate the frequency, clinical pattern and course of cutaneous adverse reaction to cardiovascular drugs.
Methods. From October 1999 until November 2004 all adverse cutaneous reactions to drugs were recorded on magnetic support, including hospitalized and outpatients of the Dermatology Department of Cagliari University. Cases related to cardiovascular drugs were further investigated for final causality assessment following the international criteria and algorithm of the World Health Organization (WHO) Collaborating Centre for Drug Monitoring.
Results. Four-hundred and nine consecutive patients affected by cutaneous ADR were studied. Antihypertensive drugs were responsible for 8.5% of the overall cases with ACE inhibitors and hydrochlorthiazide being the most reported. Exanthematous eruptions and urticaria-angioedema were the main clinical forms, followed by photosensitivity, pityriasis rosea-like eruption and lichenoid dermatitis, but several life-threatening cases were also observed, including Stevens-Johnson syndrome, toxic epidermal necrolysis and drug rash with eosinophilia and systemic signs. Due to the extension of the eruption and severity of symptoms hospitalization was required in 80% of cases. The main therapeutic measures involved drug discontinuation, antihistamine administration in all cases, supportive care and general corticosteroids in unresponsive severe eruptions and angioedema, intravenous high dose immunoglobulines in 1 case (toxic epidermal necrolysis).
Conclusion. Adverse cutaneous reactions to cardiovascular drugs are frequent, often severe and should not be underestimated in the risk-benefit evaluation of long-term treatment, especially in elderly and medicated patient
Rare emerging malignant skin tumors
No full textAs clinical skills improves and innovative diagnostic techniques become available in the field of dermatology and dermatopathology, new types or additional variants of malignant skin tumors are described. This article reviews the current nomenclature, clinico-pathological features, differential diagnosis, prognostic and therapeutic implications of some new dermato(patho)logical rare emerging skin tumors including epithelial tumors (squamous cell carcinoma with mucinous metaplasia), adnexal tumors (endocrine mucin-producing sweat gland carcinoma), soft tissue tumors of vascular differentiation (pseudolymphomatous cutaneous angiosarcoma, pseudomyogenic hemangioendothelioma), hematopoietic tumors (blastic plasmacytoid dendritic cell neoplasm) and mixed epithelial/melanocytic tumor (squamomelanocytic tumor)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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