51 research outputs found
Myelodysplastic Syndromes And Diseases With Myelodysplastic And Myeloproliferative Features [síndromes Mielodisplásicas E Mielodisplásicas/mieloproliferativas]
No full textMyelodysplastic syndromes (MDS) represent a heterogeneous group of hematologic disorders characterized by ineffective hematopoiesis and an increased risk of developing acute myeloid leukemia. In this educational article the general aspects of the physiopathology, diagnosis, and histopathological features of MDS and their role in differential diagnosis, classification and prognostic categorization are presented. The importance of clinical and laboratory evaluations, including peripheral blood and bone marrow analyses, including morphology - aspirate and core biopsy, cytogenetics, immunophenotype and careful serial follow-up is emphasized. Definite diagnosis of MDS, especially in low-risk subtypes, should consider the exclusion of disorders with reactive bone marrow alterations, such as viral infections for example HIV. The new revised World Health Organization (WHO-2008) classification is presented and discussed.314267272Nimer, S.D., Myelodysplastic syndromes (2008) Blood, 111 (10), pp. 4841-51Corey, S.J., Minden, M.D., Barber, D.L., Kantarjian, H., Wang, J.C., Schimmer, A.D., Myelodysplastic syndromes: The complexity of stem-cell diseases (2007) Nat Rev Cancer, 7 (2), pp. 118-29Steensma, D.P., The spectrum of molecular aberrations in myelodysplastic syndromes: In the shadow of acute myeloid leukemia (2007) Haematologica, 92 (6), pp. 723-727Malcovati, L., Nimer, S.D., Myelodysplastic syndromes: Diagnosis and staging (2008) Cancer Control, 15 (SUPPL.), pp. 4-13Magalhães, S.M.M., Síndromes mielodisplásticas: Diagnóstico de exclusão (2006) Rev Bras Hematol Hemoter, 28 (3), pp. 175-177(2009) Practice Guidelines: Myelodysplastic Syndromes, Version 1, , http://www.nccn.org/professionals/physician_gls/PDF/mds.pdf, National Comprehensive Cancer Network (NCCN), Available at, acessado em 02 de dezembro de 2008(2008) World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, , Swerdlow SH, Campos E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds), IARC Press: LyonBernasconi, P., Klersy, C., Boni, M., Cavigliano, P.M., Calatroni, S., Giardini, I., World Health Organization classification in combination with cytogenetic markers improves the prognostic stratification of patients with de novo primary myelodysplastic syndromes (2007) Br J Haematol, 137 (3), pp. 193-205Garcia-Manero, G., Shan, J., Faderl, S., Cortes, J., Ravandi, F., Borthakur, G., A prognostic score for patients with lower risk myelodysplastic syndrome (2008) Leukemia, 22 (3), pp. 538-43Wimazal, F., Fonatsch, C., Thalhammer, R., Schwarzinger, I., Müllauer, L., Sperr, W.R., Idiopathic cytopenia of undetermined significance (ICUS) versus low risk MDS: The diagnostic interface (2007) Leuk Res, 31 (11), pp. 1461-1468Steensma, D.P., Tefferi, A., Risk-based management of myelodysplastic syndrome (2007) Oncology (Williston Park), 21 (1), pp. 43-54Orazi, A., Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/myeloproliferative diseases (2007) Pathobiology, 74 (2), pp. 97-114Schmitt-Graeff, A., Mattern, D., Köhler, H., Hezel, J., Lübbert, M., Myelodysplastic syndromes (MDS). Aspects of hematopathologic diagnosis (2000) Pathologe, 21 (1), pp. 1-15Saad, S.T., Vassallo, J., Arruda, V.A., Lorand-Metze, I., The role of bone marrow study in diagnosis and prognosis of myelodysplastic syndrome (1994) Pathologica, 86 (1), pp. 47-51Lorand-Metze, I., Pinheiro, M.P., Ribeiro, E., de Paula, E.V., Metze, K., Factors influencing survival in myelodysplastic syndromes in a Brazilian population: Comparison of FAB and WHO classifications (2004) Leuk Res, 28 (6), pp. 587-94Orazi, A., Germing, U., The myelodysplastic/myeloproliferative neoplasms: Myeloproliferative diseases with dysplastic features (2008) Leukemia, 22 (7), pp. 1308-1
Flexibele inzet van de ontwerp en engineering capaciteit van Koninklijke de Vries Scheepsbouw
No full textKoninklijke de Vries Scheepsbouw (KDVS) vormt samen met Royal van Lent (RVL) en De Voogt Naval Architects (DVNA) een samenwerkingsverband voor de ontwikkeling, productie en verkoop van luxe megajachten. Dit samenwerkingsverband gebruikt de merknaam Feadship is een gerenomeerde naam in het exclusieve segment van de luxe megajachten. Voor Koninklijke de Vries scheepsbouw wordt een werkwijze gehanteerd vastgelegd in een operiationeel excelleren (OE) plan. In dit plan is de ontwikkeling van luxe megajachten verdeeld in de fases „Sales‟, „Design Development‟ (DD), Definitief ontwerp (DO), Detail engineering (DE), Werkvoorbereiding (WVB) en de Productie fase. Dit onderzoek is gestart omdat er problemen werden ervaren tijdens de Definitief ontwerp fase. Door de werkwijze van Koninklijke de Vries scheepsbouw met behulp van de „Delft Systems Approach‟ te analyseren zijn er verschillende problemen geconstateerd. Door de onregelmatige verkoopmoment en de „front end loading‟ doelstellingen in het OE plan fluctueerd de gevraagde capaciteit voor de DO fase sterk. Doordat de DO fase voor het grootste deel door DVNA wordt uitgevoerd zijn er beperkte mogelijkheden om met deze fluctuerende belasting om te gaan. Naast deze sterk wisselende belasting zijn voor veel processen onvoldoende richtlijnen en normen opgesteld. Door het niet opstellen van deze normen en richtlijnen is er vaak veel onduidelijkheid. Dit uit zich in frustraties over bedachte oplossingen, die of niet goed genoeg zijn, of juist niet binnen het budget passen. Ook beperkt dit de mogelijkheid om gebruik te maken van de ervaring die KDVS heeft. Nieuwe medewerkers kunnen alleen via overleg gebruik maken van de ervaring van medewerkers die al langer in dienst zijn. Na deze analyses zijn er twee richtingen waarmee de problemen kunnen worden bestreden waarvan een andere mogelijkheid om invulling te geven aan de flucuterende ontwerp en engineering capaciteit verder is onderzocht. Een andere oplossingsrichting is een verbeterd informatie systeem. Door de flucterende belasting niet alleen door DVNA te laten invullen, maar het werk flexibeler te verdelen over alle ontwerp en engineering capaciteit van KDVS ontstaan een systeem dat beter om kan gaan met de fluctuatie. Daarnaast zou een dergelijk systeem de nu zo belangrijke maar beperkte kennis overdracht tussen verschillende partijen kunnen verbeteren. Om inzicht te krijgen in de gevolgen van flexibelere inzet van de ontwerp en engineering capaciteit is een simulatiemodel ontwikkeld. Hiermee is vastegesteld of de effectiviteit van de totale vaste capaciteit in de verschillende scenario‟s kan leiden tot een verbetering van die effectiviteit met meer dan tien procent. Omdat de kosten voor het ontwikkeltraject maar beperkt aandeel hebben in de totale kosten van een megajacht is het ook nodig om vast te stellen of het ontwerp en engineering traject dan ook betere producten kan leveren. De resultaten van de simulatie geven aan dat een verbetering van de effectiviteit van de vaste capaciteit zestien procent kan bedragen in het scenario waar alle engineering en ontwerp taken voor alle te ontwikkelen megajachten verdeelt over de volledige capaciteit van KDVS. Een verbetering van twaalf procent is te realiseren als per te ontwikkelen megajacht een „vast‟ team wordt gevuld met medewerkers van alle partijen binnen KDVS. Naar aanleiding van deze resultaten wordt aanbevolen om op korte termijn het scenario met de overkoepelende teams te implementeren. Daarnaast is het nodig om de informatie-voorzieningen te verbeteren om de overige problemen verder op te lossen. Dit kan er toe leiden dat op termijn ook het nog flexibelere scenario gebruikt worden. Hoe de verbeterde effectiviteit van de ontwerp en engineeringscapaciteit gebruikt moet worden is een beleidsvraagstuk dat nog beantwoord moet worden. De mogelijkheid om een grotere vaste capaciteit beter in te zetten geeft de beste mogelijkheden om de exclusiviteit van Feadship te behouden.Mechanical, Maritime and Materials EngineeringMarine and Transport TechnologyTransport Engineering and Logistics2013.TEL.780
Sediment transport over sills of longitudinal training dams
No full textCivil Engineering and GeosciencesHydraulic Engineerin
Depth of Interaction in Columnar Scintillation Material
No full textGeometrical optics analysis is carried out in order to establish a relationship between the intensity distribution at the base plane of a column of scintillation material and the depth of interaction. Slabs of scintillation material are treated as a two dimensional model case, and the results are extended to approximations for circular and rectangular columns. The application of the detectable optical signal at the base plane of the columns for the reconstruction of the depth of interaction is also discussed.Optics in Science and TechnologyImaging Science & TechnologyApplied Science
Electron beam lithography on curved or tilted surfaces: Simulations and experiments
No full textThere is a growing interest for patterning on curved or tilted surfaces using electron beam lithography. Computational proximity correction techniques are well established for flat surfaces and perpendicular exposure, but for curved and tilted surfaces adjustments are needed as the dose distribution is no longer cylindrically symmetric with respect to the surface normal. A graphical processing unit -accelerated 3D Monte Carlo simulation, based on first-principle scattering models, is used to simulate the asymmetric dose distribution. Based on that, an approximate adjustment is made to an existing high-performance proximity effect correction (PEC) algorithm aimed at the correct exposure of a pattern of nanowires on a 17° tilted surface. It was experimentally verified that using the adjusted PEC indeed leads to a more uniform exposure on tilted surfaces.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.ImPhys/Charged Particle Optic
Charge-induced pattern displacement in E-beam lithography
No full textElectron beam lithography (EBL) requires conducting substrates to ensure pattern fidelity. However, there is an increasing interest in performing EBL on less well-conducting surfaces or even insulators, usually resulting in seriously distorted pattern formation. To understand the underlying charging phenomena, the authors use Monte Carlo simulations that include models for substrate charging, electron beam-induced current, and electric breakdown. Simulations of electron beam exposure of glass wafers are presented, exposing regular patterns which become distorted due to charge-induced beam deflection. The resulting displacements within the patterns are mapped and compared to experimental displacement maps obtained from patterns in PMMA resist on glass substrates. Displacements up to several hundreds of nanometers were observed at a primary beam energy of 50 keV. Also, various scan strategies were used to write the patterns, in the simulations as well as the experiments, revealing their strong effect on pattern distortion, in shape and in magnitude. A qualitative, in some cases even quantitative, good agreement was found between the simulations and the experiments, providing enough confidence in Monte Carlo simulations to predict charge-induced pattern displacement and shape distortion and to find smart scan strategies to minimize the effects of charging.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.ImPhys/Charged Particle Optic
Sediment transport over sills at longitudinal training dams with unaligned main flow
No full textLongitudinal training dams (LTDs) are constructed in the River Waal in the Netherlands. They are aligned parallel to the river shore and divide the river into a main and side channel. The existing groynes are removed yielding more discharge capacity at high flows. The side channel creates possibly a sheltered environment for species compared to the traditional groyne field (Collas, 2014). Although the lay-out of the LTDs has been extensively studied using numerical models (e.g. Huthoff et al., 2011), the morphodynamic response is yet unclear and depends strongly on the dimensions (length and height) of the openings. The inlet and openings (see Fig. 1) are sill-type structures which can be changed relatively easy. These sills are designed in such a way that they serve as a barrier for water and bed load sediment. To make long-term morphological predictions, it is necessary to understand the bed load transport processes over these sills. Suspended sediment transport is not considered in this study. We developed an analytical model to predict sediment transport paths on a slope, using a correction on the well-known critical Shields parameter. </p
Effects of physical exercise and body weight on disease-specific outcomes of people with rheumatic and musculoskeletal diseases (rmds): systematic reviews and meta-analyses informing the 2021 eular recommendations for lifestyle improvements in people with
No full textThis work was funded by the European League Against Rheumatism.
SMMV and JMG are supported by Versus Arthritis (grant number 21755) and the
NIHR Manchester Biomedical Research Centre. The views expressed are those of
the author(s) and not necessarily those of the NHS, the NIHR or the Department of
Health.Gwinnutt J.M., Wieczorek M., Cavalli G., Balanescu A., Bischoff-Ferrari H.A., Boonen A., De Souza S., De Thurah A., Dorner T.E., Moe R.H., Putrik P., Rodríguez-Carrio J., Silva-Fernández L., Stamm T., Walker-Bone K., Welling J., Zlatković-Švenda M.I., Guillemin F., Verstappen S.M.M
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