1,769 research outputs found
Ocular changes after simultaneous kidney-pancreas transplant
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I.V. Vorobyeva1, E.V. Bulava1, L.K. Moshetova1, A.V. Pinchuk2–4
1Russian Medical Academy of Continuous Professional Education, Moscow,
Russian Federation
2N.V. Sklifosovskiy Research Institute for Emergency Medical Aid, Moscow, Russian Federation
3A.I. Yevdokimov Moscow University of Medicine & Dentistry, Moscow, Russian Federation
4Research Institute of Public Health Organization and Medical Management, Moscow, Russian Federation
Type 1 diabetes (T1D) is one of the most common chronic diseases in young individuals. Diabetic nephropathy, being one of the most dangerous complications of T1D, progresses to end-stage renal disease within 10–15 years in 80%. The simultaneous kidney-pancreas transplant prevents insulin therapy and dialysis, thereby avoiding further progression of complications of diabetes. Normalization of carbohydrate metabolism and resolving of uremia after simultaneous kidney-pancreas transplant are beneficial for ocular structures. This article reviews studies on the pattern of changes in ocular structures in the post-transplant period. The procedure improves peripheral microcirculation of the bulbar conjunctiva and corneal innervation. Most studies demonstrate stabilization and improvement of the course of diabetic retinopathy as illustrated by the reduction in active vascular proliferation, need for retinal laser photocoagulation and vitrectomy. Meanwhile, some studi es failed to reveal any differences in the morphological functional status of the retina in the pre- and postoperative periods. An increase in cataract rate among simultaneous kidney-pancreas transplant recipients receiving immunosuppressant therapy remains a challenge.
Keywords: type 1 diabetes, kidney transplant, pancreas transplant, simultaneous kidney-pancreas transplant, diabetic retinopathy, diabetic macular edema.
For citation: Vorobyeva I.V., Bulava E.V., Moshetova L.K., Pinchuk A.V. Ocular changes after simultaneous kidney-pancreas transplant. Russian Journal of Clinical Ophthalmology. 2022;22(2):132–136 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-132-136.
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Common pathogenic aspects of diabetic retinopathy and nephropathy. Kidney transplantation and the course of diabetic retinopathy
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I.V. Vorobyeva1, L.К. Moshetova1, A.V. Pinchuk2–4, Е.V. Bulava1, Е.P. Delver5, А.А. Belogurov5
1Russian Medical Academy of Continuous Professional Education, Moscow,
Russian Federation
2N.V. Sklifosovskiy Research Institute for Emergency Medical Aid, Moscow, Russian Federation
3A.I. Evdokimov Moscow University of Medicine & Dentistry, Moscow, Russian Federation
4Research Institute of Public Health Organization and Medical Management, Moscow,
Russian Federation
5National Medical Research Center of Cardiology, Moscow, Russian Federation
Epidemics of diabetes and its complications is a global threat to the health of human population. In 2040, the number of patients with diabetes is predicted to rise to 642 million. Diabetic retinopathy and nephropathy are the most dangerous complications. Chronic hyperglycemia is a major factor that determines the development and progression of microvascular complications of diabetes including retinopathy and nephropathy. Key biological pathogenic mechanisms of microvascular complications involve over-production of reactive oxygen species and activation of intracellular signaling pathways and their modulators. OCT angiography is a safe and informative early diagnostic tool to assess vascular retinal abnormalities and to monitor treatment efficacy. Proteinuria was long considered the gold standard to evaluate and monitor kidney functions. However, one-third of patients develop diabetic nephropathy in normal albuminuria. Degradation products of glomerular filtration barrier are thought to be perspective biomarkers of early diabetic nephropathy. End-stage renal disease requires kidney transplantation. In addition to the improvement of uremic syndrome, kidney transplantation favors the course of diabetic retinopathy.
Keywords: diabetes, diabetic retinopathy, diabetic nephropathy, optical coherence tomography, OCT angiography, kidney transplantation.
For citation: Vorobyeva I.V., Moshetova L.К., Pinchuk A.V. et al. Common pathogenic aspects of diabetic retinopathy and nephropathy. Kidney transplantation and the course of diabetic retinopathy. Russian Journal of Clinical Ophthalmology. 2021;21(2):90–95. DOI: 10.32364/2311-7729-2021-21-2-90-95.
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The Life and Vegetating
No full textFor several years, A.V. Suvorov has been doing mailing lists for like-minded colleagues and friends. Each of the letters is a scientific and journalistic text on philosophical, psychological, pedagogical, and life topics. A.V. Suvorov signed his letters "Hedgehog" - that's how he called himself, meaning not only prickly, but also the desire to isolate himself for a while, shrink, withdraw into himself from the world, so that he could then turn to him with something important. We bring to your attention his latest essay, or rather, the last revision of the text that he wrote almost a quarter of a century ago. The author reflects on how to overcome universal, collective and individual, personal nonsense as a way of existence. In his opinion, didactics is intended to provide a means of understanding existence.</p
Teaching foreign students argumentation on the example of A.V. Vampilov’s “The elder son”
No full textThe article concerns ways of teaching argumentation to foreign students learning Russian as a foreign language. The author characterizes extracts of A.V. Vampilov's “The Elder Son” where different verbal persuasive means showing menthality, specifiс way of thinking and world perception of the Russians are presented
Large-eddy simulation of turbulent channel flow using the explicit algebraic subgrid-scale model
No full textLarge-eddy simulation (LES) of turbulent channel flow are performed with a new subgrid-scale (SGS) stress model. The simulations show that with this model we can well predict turbulent wall flows at coarse resolutions and moderately high Reynolds numbers. The commonly used dynamic Smagorinsky model fails at coarser resolutions
Explicit algebraic and differential Reynolds stress model application to homogeneously sheared and compressed turbulence
No full textAn explicit algebraic and differential Reynolds stress models (EARSM and DRSM) are used to investigate the influence of homogeneous shear and compression on the behaviour of turbulence in the limit of rapid distortion theory (RDT). EARSM is shown to give realizable results and to preserve RDT regime, unlike the eddy-viscosity model (EVM). The DRSM version of our model is in reasonable agreement with RDT theory
Generalissimo A.V. Suvorov: General’s Persona in Memory Politics of Early 20th Century Russian Empire
No full textThis article addresses the utilization of heroic imagery from the past within the memory politics of the early 20th century Russian Empire. The author provides a detailed analysis of the commemoration of A.V. Suvorov’s feats during the reign of Nicholas II. It is demonstrated that the centenary of Suvorov’s death catalyzed a resurgence of interest in this heroic figure. Based on archival documents and periodical press, the study shows that efforts to immortalize the general continued after the centennial anniversary. The research establishes that Victorian themes occupied a central position in the symbolic politics of autocratic power throughout this period. The author concludes that the state actively employed the heroic image of A.V. Suvorov to legitimize the existing order and unify the empire’s populace. It is emphasized that, in the early 20th century, key instruments for shaping the memory landscape included the construction of a pantheon of national heroes, the establishment of museums, the organization of celebratory ceremonies, and the execution of educational initiatives, alongside monumental commemoration. The author asserts that narratives from military history were instrumental in creating cultural infrastructure both within and beyond the state’s borders. This article is of particular interest to researchers exploring issues related to historical memory and memory politics in the early 20th century
Lutein and zeaxanthin complex: ophthalmologists’ choice
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A.V. Korneeva
LLC “Three-Z-Moscow”, Moscow, Russian Federation
This article summarizes the data on carotenoids and their role in retinal antioxidant protection. The relevance of lutein and zeaxanthin complexes and criteria for their choice are discussed. Data on the relationship between low carotenoid levels in the fovea and age-related macular degeneration (AMD) are available. There are several lutein and zeaxanthin complexes which formulations were developed according to the AREDS2. Clinical trials demonstrate that lutein and zeaxanthin complexes improve both retinal functional activity and morphological parameters and are effective to prevent AMD development and progression. They are recommended for unbalanced diet, gastrointestinal disorders, psychoemotional stresses (e.g., drivers or professional athletes), intensive ultraviolet (e.g., welders, lighters or mountain tourists), myopia, accommodation cramp, inflammatory and degenerative ocular disorders. Optimal dosing is 1 tablet per day for at least 3 months twice a year.
Key words: lutein, zeaxanthin, carotenoids, antioxidants, age-related macular degeneration.
For citation: Korneeva A.V. Lutein and zeaxanthin complex: ophthalmologists’ choice. Russian Journal of Clinical Ophthalmology. 2019;19(1):54–58.
About the author:
Alina V. Korneeva — MD, PhD, ophthalmologist.
“Three-Z-Moscow”. 3, Boris Galushkin Str., Moscow, 129301, Russian Federation.
Contact information: Alina V. Korneeva, e-mail: [email protected]. Financial Disclosure: author has no a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 17.10.2018.<br
Author Correction:A 41,500 year-old decorated ivory pendant from Stajnia Cave (Poland)
No full textCorrection to: Scientific Reports https://doi.org/10.1038/s41598-021-01221-6, published online 25 November 2021The original version of this Article contained errors in the author list where Marjolein D. Bosch was omitted from the author list, and Mikołaj Urbanowski was incorrectly listed as an author of the original Article, and has subsequently been removed.The Author contributions section now reads:“S.T. W.N. and A.N. conceived the project; S.T., W.N., A.P., M.B., S.C., M.D., H.F., A.M., M.D. B., D.P., M.P.R., C.M.R., V.S-M., G.M.S., P.S., M.S., K.S., A.V., F.W., H.W., A.W., M.Z., S.B., A.N., J-J. H., performed research; S.T., A.P., W.N., M.B., M.D.B., S.C., M.D., H.F., A.M., D.P., M.P.R., C.M.R., V.S-M., G.M.S., P.S., M.S., K.S., A.V., F.W., H.W., A.W., M.Z., S.B., A.N., J-J. H. analysed all archaeological data; S.T. and A.P. wrote the paper with the collaboration of all the co-authors.”The original Article and its accompanying Supplementary Information file have been corrected
Sense of “Axial time” in A.V. Semushkin and M.K. Mamardashvili’s creativity
No full textIn the article considers the concept of “axial time”, developed by K. Jaspers. Through a prism of A.V. Semushkin and M.K. Mamardashvili’s creativity opens its essence determined as “spiritual revolution”. Defined its specific features, as consequence of this “break to transcendent”: universalism, an opportunity of the communication, birth of philosophy, world religions and sciences; history, person and morals. Degradation the modern culture, expressing in growth of conflicts and wars, communicate the author with deviation from revelations of “axial time” that threatens mankind with self-destruction
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