135,954 research outputs found
Protecting Animals 36: Author Witi Ihimaera
No full textIn this very special episode of Knowing Animals I am joined by beloved New Zealand author Witi Ihimaera. Witi has written many books featuring nonhuman animals. He offers us a non-colonial lens through which to think about the human/nonhuman relationship
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies
No full textMutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of major RPGR isoforms (RPGR 1-19 and RPGR ORF15), we have generated isoform-specific antibodies and examined their expression and localization in the retina. Using sucrose-gradient centrifugation, immunofluorescence and co-immunoprecipitation methods, we show that RPGR isoforms localize to distinct sub-cellular compartments in mammalian photoreceptors and associate with a number of cilia-centrosomal proteins. The RCC1-like domain of RPGR, which is present in all major RPGR isoforms, is sufficient to target it to the cilia and centrosomes in cultured cells. Our findings indicate that multiple isotypes of RPGR may perform overlapping yet somewhat distinct transport-related functions in photoreceptors
Investigation of Lagrangian coherent structures in a wake-induced boundary layer transition
No full textThe evolution of coherent structures in a flat plate boundary layer transition induced by the cylinder wake is investigated using the particle image velocimetry (PIV) technique. The finite-time Lyapunov exponent (FTLE), which characterizes the amount of stretching about the flow trajectory, is used to extract the Lagrangian coherent structures. It is revealed that secondary vortex is induced by the cylinder wake vortices in the near wall region,which would evolve into hairpin vortex as it convects downstream. The subsequent evolvement of the hairpin vortex, characterized by the regeneration of offspring hairpin vortex upstream of it, leads to the appearance of the hairpin packet and the boundary layer finally reaches a turbulent state
Taxonomy and nomenclature of Salix baileyi, S. rehderiana, and S. disperma
No full textResearchers have frequently misapplied the name Salix leveilleana C.K. Schneider to S. baileyi C.K. Schneider. After detailed study of the types, relevant specimens and literature, S. leveilleana is synonymized with S. disperma Roxb. ex D. Don. Salix dolia C.K. Schneider and S. rehderiana C.K. Schneider represent the same taxon; in this study, the later one is chosen. Furthermore, the author perfected the descriptions of S. baileyi, and amend its distribution area to include Hunan and Zhejiang, China.</jats:p
Reynolds numbers near the ultimate state of turbulent Rayleigh-Bénard convection
No full textWe report on measurements of the mean-flow Reynolds number ReU and the rms fluctuation Reynolds number ReV in turbulent Rayleigh-Bénard convection as a function of the Rayleigh number Ra for 4 x 1011 < Ra < 2 1014 and Pr ' 0:8. Both can be described by the same power law with an effective exponent = 0:44, in agreement with predictions for ReU but in disagreement with predictions for ReV
The Göttingen rotating turbulent Rayleigh-Bénard convection facility
No full textThermally driven turbulent convection under the influence of global rotation is ubiquitous in nature. Well known examples are the outer convective shell of our Sun and the outer liquid core of the Earth. Trying to understand the underlying dynamics of such flows is highly challenging, not only because of the enormous range in length- and time-scales that are involved with these geo/astrophysical cases and the complex interaction of hydrodynamics with electromagnetism, but also because direct measurements on these systems are most often impossible to carry out. We gain access to direct measurements by isolating part of the problem: We focus solely on the hydrodynamical aspects of turbulent convection by performing experiments in the lab and making comparisons with direct numerical simulations (DNS). The canonical system that we use to study such flows is Rayleigh-B\'enard convection (RBC), the flow between a warm bottom plate and cold top plate, in a fluid-filled upright cylindrical cell that is rotating around its geometrical axis. This presentation will focus on the newly constructed rotating RBC facility at the Max Planck Institute for Dynamics and Self-Organization (MPIDS) in G\"ottingen
Oral pimonidazole unveils clinicopathologic and epigenetic features of hypoxic tumour aggressiveness in localized prostate cancer
No full textAbstract Background Tumor hypoxia is associated with prostate cancer (PCa) treatment resistance and poor prognosis. Pimonidazole (PIMO) is an investigational hypoxia probe used in clinical trials. A better understanding of the clinical significance and molecular alterations underpinning PIMO-labeled tumor hypoxia is needed for future clinical application. Here, we investigated the clinical significance and molecular alterations underpinning PIMO-labeled tumor hypoxia in patients with localized PCa, in order to apply PIMO as a prognostic tool and to identify potential biomarkers for future clinical translation. Methods A total of 39 patients with localized PCa were recruited and administered oral PIMO before undergoing radical prostatectomy (RadP). Immunohistochemical staining for PIMO was performed on 37 prostatectomy specimens with staining patterns evaluated and clinical association analyzed. Whole genome bisulfite sequencing was performed using laser-capture of microdissected specimen sections comparing PIMO positive and negative tumor areas. A hypoxia related methylation molecular signature was generated by integrating the differentially methylated regions with previously established RNA-seq datasets. Results Three PIMO staining patterns were distinguished: diffuse, focal, and comedo-like. The comedo-like staining pattern was more commonly associated with adverse pathology. PIMO-defined hypoxia intensity was positively correlated with advanced pathologic stage, tumor invasion, and cribriform and intraductal carcinoma morphology. The generated DNA methylation signature was found to be a robust hypoxia biomarker, which could risk-stratify PCa patients across multiple clinical datasets, as well as be applicable in other cancer types. Conclusions Oral PIMO unveiled clinicopathologic features of disease aggressiveness in localized PCa. The generated DNA methylation signature is a novel and robust hypoxia biomarker that has the potential for future clinical translation
Trust and Trustworthiness in the Fourth and Fifth Estates
No full textThe high contemporary salience in the social sciences of the topics of "trust" and "trustworthiness" has focused attention on the mass media’s putative role in eroding trust. Intrinsically, the absence in the mass media of the dialogic and interactive element to trust building identified by O’ Neill (2002) may suggest that the lack of trust and trustworthiness in the mass media is structural and recent penalties imposed by the UK communication regulator, Ofcom, on UK public service broadcasters including the BBC seem to support such a view. However, drawing on and adapting O’Neill, the author identifies two distinct potential media trust building strategies: one procedural (based in professional norms) and the second dialogic and interactive (nascent in “Web 2.0” applications). Focusing on UK Web 2.0 media sites the author identifies instances where the "dialogic" character of "Web 2.0" has established and enhanced trustworthiness. He argues normatively for a combination of "Web 2.0" interactivity and the adoption and implementation of self-regulatory codes in order to enhance the trustworthiness of the media
The author explains how he builds duck blinds on the Mousam River. Photos and d
No full textThe author explains how he builds duck blinds on the Mousam River. Photos and diagrams show technique
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