1,721,261 research outputs found
J.-C. Chasteland, J. Véron, M. Barbiéri, eds., Politiques de développement et croissance démographique rapide en Afrique (Actes de la conférence internationale "Développement et croissance démographique rapide : regard sur l'avenir de l'Afrique", Paris, 2-6 septembre 1991).
No full textSchlemmer Bernard, Pilon Marc. J.-C. Chasteland, J. Véron, M. Barbiéri, eds., Politiques de développement et croissance démographique rapide en Afrique (Actes de la conférence internationale "Développement et croissance démographique rapide : regard sur l'avenir de l'Afrique", Paris, 2-6 septembre 1991).. In: Études rurales, n°131-132, 1993. Droit, politique, espace agraire au Brésil. pp. 202-205
Control of membrane lipid homeostasis by lipid-bilayer associated sensors: A mechanism conserved from bacteria to humans
No full textThe lipid composition of biological membranes is key for cell viability. Nevertheless, and despite their central role in cell function, our understanding of membrane physiology continues to lag behind most other aspects of cell biology. The maintenance of membrane properties in situations of environmental stress requires homeostatic sense-and-response mechanisms. For example, the balance between esterified saturated (SFAs) and unsaturated fatty acids (UFAs), is a key factor determining lipid packing, water permeability, and membrane fluidity. The reduced thermal motion of lipid acyl chains triggered by an increase in SFAs causes a tighter lipid packing and increase the membrane viscosity. Conversely almost all organisms adapt to membrane rigidifying conditions, such as low temperature in poikilotherms, by incorporating more lipids with poorly packing unsaturated acyl chains. The molecular mechanisms underlying membrane homeostasis are only starting to emerge through combinations of genetics, cell biology, lipidomics, structural approaches and computational modelling. In this review we discuss recent advances in defining molecular machineries responsible for sensing membrane properties and mediating homeostatic responses in bacteria, yeast and animals. Although these organisms use remarkably distinct sensing mechanisms to mediate membrane adaptation, they suggest that the principle of transmembrane signaling to integrate membrane composition with lipid biosynthesis is ancient and essential for life.Fil: de Mendoza, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Pilon, Marc. University Goteborg; Sueci
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