1,721,304 research outputs found
CLINICAL AND MOLECULAR RESULTS OF THE GERMAN PHASE II STUDY HIT-HGG-CILMETRO: CILENGITIDE AND METRONOMIC TEMOZOLOMIDE FOR RELAPSED/REFRACTORY HIGH GRADE GLIOMAS/DIPG IN CHILDREN AND ADOLESCENTS
No full textCLINICAL AND MOLECULAR RESULTS OF THE GERMAN PHASE II STUDY HIT-HGG-CILMETRO: CILENGITIDE AND METRONOMIC TEMOZOLOMIDE FOR RELAPSED/REFRACTORY HIGH GRADE GLIOMAS/DIPG IN CHILDREN AND ADOLESCENTS
No full textHISTOPATHOLOGICAL GRADING ACCORDING TO THE WHO CLASSIFICATION OF CNS TUMORS AND H3.3K27 MUTATIONAL STATUS REPRESENT INDEPENDENT PROGNOSTIC MARKERS IN PEDIATRIC HIGH GRADE GLIOMAS
No full textHISTOPATHOLOGICAL GRADING ACCORDING TO THE WHO CLASSIFICATION OF CNS TUMORS AND H3.3K27 MUTATIONAL STATUS REPRESENT INDEPENDENT PROGNOSTIC MARKERS IN PEDIATRIC HIGH GRADE GLIOMAS
No full textIntramedullary gangliogliomas: histopathologic and molecular features of 25 cases
Full text linkGangliogliomas are uncommon glioneuronal tumors, which usually arise in the cerebral hemispheres and occasionally in the brain stem. Gangliogliomas occurring in the spinal cord are extremely rare. In this study, we analyzed the clinical, histopathologic, and molecular features of 25 spinal gangliogliomas. The cases included in our series affected mostly children and young adults (15 males and 10 females; mean age, 20 years; median age, 14 years; age range, 1-72 years) and were predominantly localized in the cervical and thoracic spine. From the clinical point of view (detailed follow-up available for 9 pediatric cases; mean follow-up: 2 years 10 months; range, 3 months to 5 years 10 months), most patients showed stable disease after subtotal resection. Radiotherapy was rarely used as adjuvant treatment. Histologically, gangliogliomas (WHO grade I) (21 cases) showed features largely similar to their supratentorial counterparts. Anaplastic gangliogliomas (World Health Organization grade III) (4 cases) showed features of anaplasia (including high cellularity and increased mitotic and proliferation activity). From a molecular point of view, only 2 tumors (2/19, 11%) harbored a BRAFV600E mutation. In conclusion, although spinal gangliogliomas display histologic and clinical features similar to their supratentorial counterparts, they show a relatively low frequency of BRAFV600E mutations, alteration otherwise common in hemispheric and brain stem gangliogliomas
Histopathological grading according to the WHO classification of CNS tumors and H3.3K27 mutational status represent independent prognostic markers in pediatric high grade gliomas
No full textSelection of food and ranging behaviour in a sexually monomorphic folivorous lemur: Lepilemur ruficaudatus
No full textMonomorphic lemurs of Madagascar allow us to investigate whether there are behavioural mechanisms that compensate for sex-specific differences in the costs of maintenance and reproduction in arboreal primates. Food selection of the pair-living Lepilemur ruficaudatus was studied in relation to food chemistry, and travel distances were measured as possible indications of differential investment in ranging activities (possibly related to the defence of territories and/or mating opportunities). Fourteen females and 14 males were radio-tracked for a total of 365 half-nights (from dusk to midnight or from midnight to dawn) at different times of the year (birth, lactation and weaning, pre-mating, post-mating). When based on monthly means, the two sexes did not differ in nightly travel distances. Food selection of females and males did not differ in relation to the chemical composition of leaves, but fruits consumed by females had lower fibre contents than fruits consumed by males. Even though other behavioural data are fragmentary, little evidence exists for behavioural mechanisms in L. ruficaudatus to compensate for the different energetic costs of females and males
Histopathological grading according to the WHO classification of CNS tumors and H3.3K27 mutational status represent independent prognostic markers in pediatric high grade gliomas
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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