347 research outputs found

    Generation: memoirs and personal essays

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    Geneeration: Memoirs and Personal Essays is a collection of non-fiction essays concerned with the themes of family, inheritance, and genetic and cultural influences.M.F.A.by Dorothea Cumming

    Dorothea J. Snow, 1954 Visit

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    A group of summer students taking children\u27s literature at Jacksonville State College are shown with noted author Dorothea J. Snow. Shown from left are Doris Holder, Dorothea J. Snow, Sylvia Alverson, and Lillian Thomas.https://digitalcommons.jsu.edu/lib-ac-histimg/34805/thumbnail.jp

    Die historische und ekklesiologische Tiefe voll ausschöpfen. Respons zum Beitrag von Dorothea Sattler

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    This contribution responds to Dorothea Sattler’s thoughts about ecclesiology in an ecumenical context. First it describes in short the influence of Kurt Stalder’s theology for his generation of Old Catholic theologians, parish priests and lay people, as well as his contribution to the ecumenical theology in the 20th century. After that the author reacts on the three parts of Sattler’s contribution: on the Petrine function, on the apostolicity of ministry and on contemporary plurality and the unity of the church

    Functional characterization of the HuR:CD83 mRNA interaction.

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    Maturation of dendritic cells (DC) is characterized by expression of CD83, a surface protein that appears to be necessary for the effective activation of naïve T-cells and T-helper cells by DC. Lately it was shown that CD83 expression is regulated on the posttranscriptional level by interaction of the shuttle protein HuR with a novel posttranscriptional regulatory RNA element (PRE), which is located in the coding region of the CD83 transcript. Interestingly, this interaction commits the CD83 mRNA to efficient nuclear export via the CRM1 pathway. To date, however, the structural basis of this interaction, which potentially involves three distinct RNA recognition motifs (RRM1-3) in HuR and a complex three-pronged RNA stem-loop element in CD83 mRNA, has not been investigated in detail. In the present work we analyzed this interaction in vitro and in vivo using various HuR- and CD83 mRNA mutants. We are able to demonstrate that both, RRM1 and RRM2 are crucial for binding, whereas RRM3 as well as the HuR hinge region contributed only marginally to this protein:RNA interaction. Furthermore, mutation of uridine rich patches within the PRE did not disturb HuR:CD83 mRNA complex formation while, in contrast, the deletion of specific PRE subfragments from the CD83 mRNA prevented HuR binding in vitro and in vivo. Interestingly, the observed inhibition of HuR binding to CD83 mRNA does not lead to a nuclear trapping of the transcript but rather redirected this transcript from the CRM1- towards the NXF1/TAP-specific nuclear export pathway. Thus, the presence of a functional PRE permits nucleocytoplasmic trafficking of the CD83 transcript via the CRM1 pathway

    Diaspora: Exile and the Jewish Condition

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    Dorothea Braginsky is a contributing author, Exile in America: Strangers in Paradise?.https://digitalcommons.fairfield.edu/psychology-books/1001/thumbnail.jp

    Construction of Madness: Emerging Conceptions and Interventions

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    Dorothea Braginsky is a contributing author, The Myth of Schizophrenia

    Deviant Behavior: Readings in the Sociology of Deviance

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    Dorothea Braginsky is a contributing author, Schizophrenics in the psychiatric interview: a study of their interpersonal effectiveness

    A Century of Psychology as Science

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    Dorothea Braginsky is a contributing author, Psychology: Handmaiden of Society\u27.https://digitalcommons.fairfield.edu/psychology-books/1000/thumbnail.jp

    The Failure of the marriage between Dorothea Brooke and Edward Casaubon in George Eliot's middlemarch

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    This paper deals with marriage failure found in George Eliot?s novel Middlemarch, seen through Dorothea Brooke and Edward Casaubon. The thesis writer is interested in finding the factors that cause their marriage to fail. She assumes that the failure is caused by both Dorothea and Mr. Casaubon. Therefore, the thesis writer needs to divide the factors into two groups; the factors that cause the failure of the marriage from Dorothea?s side as well as from Mr. Casaubon?s side. From the author?s characterization, which reveals Dorothea and Mr. Casaubon?s attitudes, the thesis writer finds out the causes of the failure. Besides, the description of Victorian women and marriage helps the thesis writer understand the causes of the failure. The thesis writer concludes that Dorothea and Mr. Casaubon fail in their marriage because of some factors such their character traits, the absence of love and the difference of age. The fact that Dorothea has been disillusioned about her husband and marriage makes her unhappy with her marriage
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