335,653 research outputs found
Performance Approximation and Design of Pick-and-Pass Order Picking Systems
No full textIn this paper, we discuss an approximation method based on G/G/m queuing network modeling using Whitt’s (1983) queuing network analyzer to analyze pick-and-pass order picking systems. The objective of this approximation method is to provide an instrument for obtaining rapid performance estimates (such as order lead time and station utilization) of the order picking system. The pick-and-pass system is decomposed into conveyor pieces and pick stations. Conveyor pieces have a constant processing time, whereas the service times at a pick station depend on the number of order lines in the order to be picked at the station, the storage policy at the station, and the working methods. Our approximation method appears to be sufficiently accurate for practical purposes. It can be used to rapidly evaluate the effects of the storage methods in pick stations, the number of order pickers at stations, the size of pick stations, the arrival process of customer orders, and the impact of batching and splitting orders on system performance.simulation;warehousing;order picking;queuing network;pick-and-pass
Order batching in multi-server pick-and-sort warehouses.
No full textIn many warehouses, customer orders are batched to profit from a reduction in the order picking effort. This reduction has to be offset against an increase in sorting effort. This paper studies the impact of the order batching policy on average customer order throughput time, in warehouses where the picking and sorting functions are executed separately by either a single operator or multiple parallel operators. We present a throughput time estimation model based on Whitt's queuing network approach, assuming that the number of order lines per customer order follows a discrete probability distribution and that the warehouse uses a random storage strategy. We show that the model is adequate in approximating the optimal pick batch size, minimizing average customer order throughput time. Next, we use the model to explore the different factors influencing optimal batch size, the optimal allocation of workers to picking and sorting, and the impact of different order picking strategies such as sort-while-pick (SWP) versus pick-and-sort (PAS)Order batching; Order picking and sorting; Queueing; Warehousing;
Aspectes moleculars de dues malalties de transport lisosòmic: la cistinosi i la malaltia de Niemann-Pick tipus C
No full text[cat] La cistinosi i la malaltia de Niemann-Pick tipus C (NPC) són dues patologies hereditàries monogèniques poc freqüents, per aquest motiu estan classificades dins del grup de malalties anomenades rares. La cistinosi està causada per mutacions al gen CTNS, que codifica per una proteïna transmembrana del lisosoma que rep el nom de cistinosina. En canvi, la malaltia de NPC és deguda a mutacions al gen NPC1 o al gen NPC2, que codifiquen per una proteïna integral de la membrana lisosòmica i una proteïna soluble del lisosoma, respectivament, i aquestes reben el mateix nom que el gen, NPC1 i NPC2. El funcionament incorrecte d’aquestes proteïnes de transport dóna lloc a una acumulació de productes, diferent a ambdós casos, a l’interior del lisosoma, sent classificades com a malalties d’acumulació lisosòmica. Aquesta tesi doctoral s’ha centrat en l’anàlisi molecular de pacients afectes d’alguna d’aquestes dues malalties.
S’ha realitzat el primer estudi mutacional de cistinosi a la població espanyola, que ha permès la identificació de 15 mutacions diferents, 7 de les quals no havien estat descrites: tres mutacions de canvi de sentit (p.M1T, p.S270F i p.G309V), tres delecions (c.1-19_61del, c.295_310del i c.320_323delATCA) i una mutació de splicing (c.682-1G>T). La deleció de 57 kb és la mutació més freqüent a Espanya (38% dels al•lels) i conjuntament amb altres 5 mutacions representen el 73% dels al•lels estudiats. S’ha establert que els pacients amb fenotip clínic infantil tenen a ambdós al•lels mutacions que trunquen o que afecten aminoàcids conservats de les regions transmembrana de la proteïna. En canvi, la mutació p.S139F s’ha associat a la forma juvenil de la malaltia.
L’estudi mutacional realitzat a la malaltia de Niemann-Pick tipus C ha permès establir el genotip d’un gran nombre de pacients, identificant 74 mutacions diferents, 17 de les quals no havien estat descrites: set mutacions de canvi de sentit (p.P474A, p.G535V, p.F995L, p.F1079S, p.L1106P, p.G1209E i p.S1249G), dues mutacions sense sentit (p.Q775X i p.E1089X), dues insercions (p.L1117PfsX4 i p.I1061NfsX4), una deleció en pauta (p.N916del), quatre mutacions de splicing (c.58-3280C>G, c.882-28A>T, c.2604+5G>A i c.3591+5G>A) i la primera gran deleció que afecta al gen NPC1 i gens flanquejants. També s’han pogut establir correlacions genotip-fenotip per a un conjunt de mutacions.
També s’ha demostrat la implicació de diferents mecanismes cel•lulars en la malaltia de Niemann-Pick tipus C, segons els tipus de mutacions causants: el “splicing”, el procés de “nonsense-mediated mRNA decay” i la degradació proteica portada a terme pel proteasoma. S’han identificat mutacions intròniques profundes i s’ha caracteritzat el seu efecte en el mRNA, conjuntament amb el de les mutacions de “splicing” que afecten als llocs canònics. El mecanisme de NMD és el responsable de la degradació del mRNA en tots els al•lels analitzats que codifiquen per un PTC al gen NPC1. La majoria de mutacions de canvi de sentit analitzades condueixen a una reducció significativa o a l’absència de la proteïna NPC1, degut a què la proteïna NPC1 mutada és degradada per la via de la ubiquitina-proteasoma. La proteïna NPC1 mutada recuperada, després del tractament amb els inhibidors del proteasoma (ALLN i MG132), és capaç de disminuir els nivells de colesterol a totes les línies cel•lulars NPC estudiades. Aquesta observació podria obrir la porta a l’ús d’aquests fàrmacs com a futur tractament per a la malaltia de NPC causada per determinades mutacions de canvi de sentit.[eng] “Molecular aspects of both lysosomal transport diseases: cystinosis and Niemann-Pick disease type”. The cystinosis and Niemann-Pick disease type C (NPC) are two rare monogenic hereditary diseases. The cystinosis is caused by mutations in the gene CTNS, which encodes a transmembrane protein of the lysosome that is called cystinosin. NPC disease is caused by mutations in the NPC1 or NPC2 gene, encoding an integral lysosomal membrane protein and a soluble protein of the lysosome, respectively, and these are the same name as the gene, NPC1 and NPC2. The impaired transport leads to an accumulation of products, different in both cases, inside the lysosome, being classified as lysosomal storage disorders. This thesis has focused on the molecular analysis of patients with any of these diseases.
Molecular analysis in the Spanish cystinosis patients has allowed the identification of 15 different mutations, 7 of which had not been described. The 57-kb deletion is the most common mutation in Spain (38% of alleles) and together with other 5 mutations accounted for 73% of the studied alleles. The p.S139F mutation has been associated with the juvenile form of the disease.
Molecular analysis in NPC disease has established the mutation profile in a large number of patients. 74 different mutations have been identified, 17 of which had not been described previously, including the first large deletion affecting the whole NPC1 gene and flanking genes. Genotype-phenotype correlations have been established for several mutations.
Different cellular mechanisms are involving in NPC disease: splicing, nonsense-mediated mRNA decay and proteasomal degradation. Deep intronic mutations have been identified and the effect on the mRNA has been characterized. NMD process is responsible for the mRNA decay for all analyzed NPC1 PTC-encoding mutations. Several missense mutations lead to a significant reduction or absence of NPC1 protein, because the NPC1 mutant protein is degraded by the ubiquitin-proteasome pathway. Treatment with proteasome inhibitors partially reverses the NPC1 decrease and reduces cholesterol levels in all studied NPC cell lines. This observation might represent a therapeutical approach for future treatments of NPC disease caused by specific missense mutations
Magnetic Design Considerations to Improve Non-Linear Characteristics of Inductively Coupled Power Transfer Systems
No full textThe paper discusses the magnetic features of various pick-up arrangements of Inductively Coupled Power Transfer systems. The performance of the standard monorail system containing an E-pickup can be improved by using S- or Z-shaped magnetic circuits. Moreover, in the case of the Z-pickup, it is possible to benefit from the positive mutual coupling if an alternate-direction configuration is adopted
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Prostory Sobolevova typu na metrických prostorech s mírou
No full textTitle: Sobolev-Type Spaces on Metric Measure Spaces Author: RNDr. Lukáš Malý Department: Department of Mathematical Analysis Supervisor: Prof. RNDr. Luboš Pick, CSc., DSc., Department of Mathematical Analysis Abstract: is thesis focuses on function spaces related to rst-order analysis in abstract metric measure spaces. In metric spaces, we can replace distributional gra- dients, whose de nition depends on the linear structure of Rn , by upper gradients that control the functions' behavior along all recti able curves. is gives rise to the so-called Newtonian spaces. e summability condition, considered in the thesis, is expressed using a general Banach function lattice quasi-norm and so an extensive framework is built. Sobolev-type spaces (mainly based on the Lp norm) on metric spaces, and Newtonian spaces in particular, have been under intensive study since the mid- s. Standard toolbox for the theory is set up in this general setting and Newto- nian spaces are proven complete. Summability of an upper gradient of a function is shown to guarantee the function's absolute continuity on almost all curves. Ex- istence of a unique minimal weak upper gradient is established. Regularization of Newtonian functions via Lipschitz truncations is discussed in doubling Poincaré spaces using weak boundedness of maximal...Název práce: Prostory Sobolevova typu na metrických prostorech s mírou Autor: RNDr. Lukáš Malý Katedra (ústav): Katedra matematické analýzy Vedoucí disertační práce: Prof. RNDr. Luboš Pick, CSc., DSc., Katedra matematické analýzy Abstrakt: Tato disertační práce se zaměřuje na prostory funkcí spojené s analýzou prvního řádu na abstraktních metrických prostorech s mírou. V metrických prosto- rech lze nahradit distributivní gradienty, jejichž de nice závisí na lineární struktuře Rn , gradienty horními, které regulují chování funkcí podél všech rekti kovatelných křivek. Pomocí nich se pak zavádí newtonovské prostory. Podmínka integrovatel- nosti, jež se v této práci uvažuje, je vyjádřena pomocí kvazinormy obecných Bana- chových svazů měřitelných funkcí, díky čemuž se vystaví rozsáhlý teoretický rámec. Prostory Sobolevova typu na metrických prostorech (postavené především na Lp normě), zvláště pak newtonovské prostory, byly podrobeny intenzivnímu studiu od poloviny . let . století. Vybudujeme standardní nástroje pro teorii v plné obecnosti a ukážeme, že new- tonovské prostory jsou úplné. Integrovatelnost horního gradientu zaručí, že funkce je absolutně spojitá podél skoro všech křivek. Dokážeme, že existuje jednoznačně určený minimální slabý horní gradient. Dále nahlédneme na regularizaci newto- novských funkcí...Katedra matematické analýzyDepartment of Mathematical AnalysisFaculty of Mathematics and PhysicsMatematicko-fyzikální fakult
Banachovy prostory funkcí
No full textN'a/ev prace: Banarhovy prostory fuiikci Autor: Jan Marko Katcdr;i: KaTedra inaleniaticke analy/y Yedouci bakalarske prace: doc1. UN Dr. Lubus Pick. CSc.. DSc. t'-inail vedoudho: Lubos.Pick'i'inff.cuni.c/ Abst.ra.kt.: V t.ejto ])riici su popisane xakladne vlastnosti Baimchovho priostoru funkcii. jeho podpriestor funkfii s absolutnc spujitou iiorniou a asociovany Banai-liov priestor I'luikcii. Zaobcra sa lie/ problcinal.ikou Lcbcsgucovycli pricslorov ['unkcii. branycli ako Banadiovo priest ory funkcif. \ Icxte su vyprarovaiu'1 priklady lykajuce sa.vlastnosti niicr ineratel'nych priosl.orov a k-h vplyv na ist udovanc'1 podpricstory. Taklio/ su vypracovaiK'1 priklady Baiia- chovyi'li iiorioni. iin ])n'sliisiio limiacliovc priest ory funkfii a. ich /;ikladne. N'la Klfcova slova: Banacliuva noriiia. Banacliov prieslor I'uukcif, asociovany prieslor. spojita noriua Title: Banach funct ion spaces Author: Jan Marko Department: Department of Mathematical Analysis Supervisor: doc. HNDr. Lubus Pick, CSc.. DSc. 'rvisor's e-mail address: Lubos.Pick'imir.cuni.cx Abstract: This thesis describes basic properties of Banach function spaces, its subspace of functions of absolutely continuous norm and its associa.lt; space.. II.also deals with problems of Lebesgue spaces considered to be Banach function spaces. Several problems...N'a/ev prace: Banarhovy prostory fuiikci Autor: Jan Marko Katcdr;i: KaTedra inaleniaticke analy/y Yedouci bakalarske prace: doc1. UN Dr. Lubus Pick. CSc.. DSc. t'-inail vedoudho: Lubos.Pick'i'inff.cuni.c/ Abst.ra.kt.: V t.ejto ])riici su popisane xakladne vlastnosti Baimchovho priostoru funkcii. jeho podpriestor funkfii s absolutnc spujitou iiorniou a asociovany Banai-liov priestor I'luikcii. Zaobcra sa lie/ problcinal.ikou Lcbcsgucovycli pricslorov ['unkcii. branycli ako Banadiovo priest ory funkcif. \ Icxte su vyprarovaiu'1 priklady lykajuce sa.vlastnosti niicr ineratel'nych priosl.orov a k-h vplyv na ist udovanc'1 podpricstory. Taklio/ su vypracovaiK'1 priklady Baiia- chovyi'li iiorioni. iin ])n'sliisiio limiacliovc priest ory funkfii a. ich /;ikladne. N'la Klfcova slova: Banacliuva noriiia. Banacliov prieslor I'uukcif, asociovany prieslor. spojita noriua Title: Banach funct ion spaces Author: Jan Marko Department: Department of Mathematical Analysis Supervisor: doc. HNDr. Lubus Pick, CSc.. DSc. 'rvisor's e-mail address: Lubos.Pick'imir.cuni.cx Abstract: This thesis describes basic properties of Banach function spaces, its subspace of functions of absolutely continuous norm and its associa.lt; space.. II.also deals with problems of Lebesgue spaces considered to be Banach function spaces. Several problems...Katedra matematické analýzyDepartment of Mathematical AnalysisFaculty of Mathematics and PhysicsMatematicko-fyzikální fakult
Reporting from the Field: The Narrative Reconstruction of Experience in Pick-up Artist Online Communities
No full textThis study focuses on the reconstruction of experience in the online environment of the Pick-up Artist (PUA) community forums and aims to uncover yet another facet of personal narrative, namely the role and performance of framing in the reporting of events. Discursive psychologists have often pointed out that a narrative is not a precise reflection of reality but a device that itself shapes the social world because reality always under-determines the verbal representation of events. In this study, we show how the verbalisation of narrative guides the reader towards the intended understanding by establishing the shared knowledge schema in the community of practice. Utilising data from a specific genre in the PUA forums, the “field reports” (i.e. narrative reconstructions of encounters between the PUAs and women), we describe three pertinent layers of frames, how they are evoked linguistically and how they interact with each other. Our investigation of the hierarchical framing of the interaction as [pua training], [personal narrative] and [success report] shows that they are based on group-specific knowledge schemas but, at the same time, draw on conventionalised narrative structures
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