118,105 research outputs found
Codice di Napoleone il Grande pel Regno d\u27Italia
No full textFirenze : presso Guglielmo Piatti, 1806
Segn.: [1]/4 2-31/4 ast2.
Mutilo della c. *2. Legatura in cartone rigido con dorso in pelle.
https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma99001725177020604
Come leggere le riviste in medicina. Dalla consultazione al bisogno alla lettura attiva per accorgersi delle nuove evidenze
No full textRiassunto. I medici non possono praticare un’assistenza di buona qualità senza aggiornare le proprie conoscenze; la lettura è una componente essenziale dell’educazione continua in medicina e per questo le abitudini di lettura del medico sono state spesso studiate negli ultimi anni. I bisogni di informazione sorgono solitamente nel corso della visita del paziente e sono per lo più collegati alla strategia diagnostica e terapeutica. Cercare risposta a queste domande utilizzando le fonti primarie, come le riviste scientifiche, richiede molto tempo ed è spesso frustrante. La consultazione “al bisogno” dovrebbe essere integrata con un monitoraggio proattivo delle nuove evidenze che emergono dalla letteratura scientifica. Organizzarsi a tale fine non è semplice: saper gestire il proprio tempo, essere capaci di selezionare e lavorare in gruppo, stabilire una continuità tra tempo libero e tempo del lavoro, conoscere gli strumenti per il critical appraisal sono i passaggi critici per un soddisfacente apprendimento lungo l’intero corso della vita professionale. L’obiettivo di questa rassegna è aiutare il medico a comprendere il modo per gestire meglio le conoscenze cliniche e mantenersi al passo dei progressi della letteratura biomedica
The Routledge Companion to Literature and Food
No full textBrien, DL ORCiD: 0000-0002-9005-3645The Routledge Companion to Literature and Food explores the relationship between food and literature in transnational contexts, serving as both an introduction and a guide to the field in terms of defining characteristics and development. Balancing a wide-reaching view of the long histories and preoccupations of literary food studies, with attentiveness to recent developments and shifts, the volume illuminates the aesthetic, cultural, political, and intellectual diversity of the representation of food and eating in literature
L-Arginine enriched biscuits improve endothelial function and glucose metabolism : a pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome
No full textObjective. The aim of this study was to evaluate the effects of a new L-rginine-enriched biscuit on endothelial function, insulin sensitivity/secretion and body composition.
Materials/Methods. The project was composed of two studies. The first study was an acute pilot postprandial study in 7 healthy subjects that evaluated bio-availability and vascular effects of L-arginine-enriched biscuits that contained 6.6gL-arginine, 21.9g carbohydrates, 3.6g protein, 7.5g fat and 4.3g dietary fiber compared with placebo biscuits and 6.6g powdered L-arginine. Subjects underwent the tests in random order, in at least 14-day intervals. The second study was a double-blind crossover study in 15 obese subjects with IGT and MS. These subjects consumed 6.6g of L-arginine-enriched biscuits or placebo biscuits in a 1600kcal diet. Each study period lasted 2weeks with a 2-week washout in between.Endothelial function, glucose tolerance, insulin sensitivity and insulin secretion were evaluated at the end of each intervention period.
Results. In the first study, the groups that received the L-arginine-enriched biscuits and the powdered L-arginine had similarly increased L-arginine, NOx and cGMP levels and postischemic blood flow (PI-BF). In both cases, these levels were significantly higher than those in the placebo biscuit recipient group. In the second study, the L-arginine-enriched biscuit recipient group displayed increased L-arginine, NOx, cGMP, PI-BF, and Matsuda index levels, whereas their circulating glucose, proinsulin/insulin ratio and fat mass were decreased compared with the placebo biscuit recipient group.
Conclusions. L-Arginine-enriched biscuits with low sugar and protein content enhance endothelial function and improve glucose metabolism, insulin sensitivity and insulin secretion in subjects with IGT and MS
Clearance mucociliare per immagini
No full textThe main steps of the optical and electronic magnification are described in the article, from the simple lens to the modern microscopy. To the aim of the paper (consisting in furnishing images clarifying features dealing with cells and secretions characterising the capacity of the bronchial mucosa to clear damaging or anyhow extraneous inhaled substances) better images are furnished by the scanning electron microscope, the only able to give " tridimesional" views of the examined sample, thank to the freeze fracture technique. Images are so presented dealing with the ciliated carpet covering the epithelial surface of the bronchial mucosa, as well as with individual ciliated cells with apical appendices (cilia) catched in most different expressions of their metacronal movement (ciliary beating) aimed, in physiologic conditions, to pin and move with aise the supra-ciliary gel-layer of mucus due to the fact that they beat into a watery sol-layer. Other images represent non-ciliated cells, some of which provided with surface appendices much smaller than cilia (brush cells), some located at the base of the epithelium not reaching its surface (basal cells), and other provided with secretory activity, named goblet cells, in cartilagineous bronchi and in non-cartilagineous bronchioli, while in the most peripheral bronchioli the latter progressively decrease in number, while other more globous secretory cells named Clara cells progressively take their place. Rather rare images of goblet cells are here published, catched in the very moment of the mucus secretion, followed by emptying of the cell itself, with the mucus collected by the nearby cilia, phenomenon which initiates the important mechanism of mechanical airway defense known under the name of muco-ciliary clearance
Numerical assessment of hydraulic properties of Triply Periodic Minimal Surfaces structures
No full textThe present work is devoted to evaluating the hydraulic properties of Triply Periodic Minimal Surfaces (TPMS) structures, a generation of porous structures developed using the periodicity of trigonometric equations to generate triply periodic minimal surfaces. The thorough computational and experimental analysis coupled with verification assessment is key to using these product structures in thermal hydraulics especially to address industrial requirements. Here the hydraulic properties are computed by performing three-dimensional CFD analyses using Star-CCM+. Gyroid TPMS was hydraulically analyzed with a water flow in three-channel configurations (circular, square, and rectangular section), with the same hydraulic diameter and length, respectively 5.08cm and 10cm. Their porosity values range from 80% to 93% depending on the unit cell dimensions (chosen values were 10mm, 15mm, 20mm, 25mm, and 30mm). The CFD models for the rectangular TPMS contain the maximum epistemic uncertainty of 19% following the ASME VV 20 codes. In preparation for the forthcoming test campaign, the hydraulic characteristic of the different channels is assessed comparatively, and the friction factors are computed and compared to reach a basic understanding of the parametric effect of channel shape and cell size
Formulation comprising arginine, use and preparation thereof
No full textIn the present invention, a uniformly shaped food product comprising a high content in L-arginine and a low content in sugars and proteins was obtained. In particular, the food product is produced by means of sonication, a process conducted at low temperature range, which prevents the degradation of the amino acid by Maillard reactions or other heat dependent modification
Gestione del cambiamento attraverso le revisioni sistematiche come strumenti per orientare la pratica clinica: risultati preliminari di una collaborazione tra l'IRCCS Istituto Ortopedico Galeazzi e il Centro Cochrane Italiano (CCI)
No full textIntroduzione
L’Istituto Ortopedico Gaeazzi è un IRCCS polispecialistico di 350 posti letto, prevalentemente ortopedici. La leadership culturale dell’ente nell’ortopedia era tradizionalmente legata al prestigio accumulato nel tempo, alla presenza di scuole di specialità e a chirurghi di fama. La produzione scientifica era caratterizzata dalla pubblicazione di studi quasi-sperimentali (serie di casi), e in misura ridotta, da studi controllati. Oggi questo modello
è messo in discussione, perché sempre di più le scelte clinico terapeutiche necessitano di essere supportate da solide prove scientifiche ottenute attraverso sperimentazioni rigorose.
Obiettivo
Realizzare un programma che preveda la promozione e la produzione di linee-guida scientifiche attraverso la metodologia GRADE (Grading of Recommendations Assessment, Development and Evaluation) e di revisioni sistematiche.
Metodi e risultati
Per facilitare l’uptake di nuove conoscenze metodologiche è stata avviata una collaborazione tra Galeazzi e CCI, affiancando quindi ai clinici figure di supporto metodologico. E’ stato avviato un programma di formazione sviluppato su rilevanti problematiche ortopediche.Infine stato sono esplorati alcuni quesiti clinici, per selezionarne due da trasformare in una revisione sistematica e una linea guida.Il percorso formativo in aula è stato caratterizzato da un’iniziale non ottimale partecipazione. Gli incontri hanno affrontato le metodologie evidence-based e la valutazione critica della letteratura scientifica per prendere decisioni al letto del paziente. L’approccio didattico favoriva la discussione tra pari e
esercitazioni pratiche in piccoli gruppi. L’afflusso di partecipanti è aumentato durante le sessioni e si è concluso con la costituzione di un gruppo attivo e interessato.
Il gruppo ha poi cominciato la stesura di una revisione sistematica della letteratura dal titolo “Definizione dei fattori di rishio di per chirurgia riparativa delle fratture di femore: qual è il tempo d’attesa preoperatorio ottimale?” e avviato la produzione di una linee guida con il sistema GRADE per un uso ottimale delle sacche di sangue dopo interventi di chirurgia
ortopedica maggiore.
Conclusioni
La partecipazione dei clinici ortopedici allo sviluppo di prove di efficacia dovrebbe affiancarsi stabilmente all’attività clinica, con un continuo scambio. Questo dovrebbe
facilitare la diffusione di una cultura evidence-based, con ricadute positive sino ai pazienti. Questi cambiamenti sono lenti e in parte indipendenti dalle attività Galeazzi-Cochrane,
appartengono cioè alla categoria delle modificazioni medico-sociali. Questa collaborazione ha l’ambizione di accelerare questi cambiamenti e aumentare il pay-back in termini di
pubblicazioni, grant e leadership culturale
New instruments and technologies for Cultural Heritage survey: full integration between point clouds and digital photogrammetry
No full textIn the last years the Geomatic Research Group of the Politecnico di Torino faced some new research topics about new instruments for point cloud generation (e.g. Time of Flight cameras) and strong integration between multi-image matching techniques and 3D Point Cloud information in order to solve the ambiguities of the already known matching algorithms. ToF cameras can be a good low cost alternative to LiDAR instruments for the generation of precise and accurate point clouds: up to now the application range is still limited but in a near future they will be able to satisfy the most part of the Cultural Heritage metric survey requirements. On the other hand multi-image matching techniques with a correct and deep integration of the point cloud information can give the correct solution for an "intelligent" survey of the geometric object break-lines, which are the correct starting point for a complete survey. These two research topics are strictly connected to a modern Cultural Heritage 3D survey approach. In this paper after a short analysis of the achieved results, an alternative possible scenario for the development of the metric survey approach inside the wider topic of Cultural Heritage Documentation is reporte
Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients
No full textOBJECTIVE - The aim of this study was to evaluate whether long-term administration of L-arginine acting through a normalization of NO/cyclic-guanosine-3′5′-cyclic monophosphate (cGMP) pathway was able to ameliorate peripheral and hepatic insulin sensitivity in 12 lean type 2 diabetic patients. RESEARCH DESIGN AND METHODS - A double-blind study was performed for 3 months. In the first month, patients were treated with their usual diet. Then they were randomly allocated into two groups. In group 1, patients were treated with diet plus placebo (orally three times per day) for 2 months. In group 2 patients were treated for 1 month with diet plus placebo (orally, three times per day) and then for 1 month with diet plus L-arginine (3 g three times per day). At the end of the first and the second month of therapy, patients underwent a euglycemic-hyperinsulinemic clamp combined with [6,6-2H2] glucose infusion. A total of 10 normal subjects underwent the same test as control subjects. RESULTS - In group 1, no changes in basal cGMP levels, systolic blood pressure, forearm blood flow, glucose disposal, and endogenous glucose production were observed throughout. In group 2, L-arginine normalized basal cGMP levels and significantly increased forearm blood flow by 36% and glucose disposal during the clamp by 34%, whereas it decreased systolic blood pressure and endogenous glucose production by 14 and 29%, respectively. However, compared with normal subjects, L-arginine treatment was not able to completely overcome the defect in glucose disposal. CONCLUSIONS - L-Arginine treatment significantly improves but does not completely normalize peripheral and hepatic insulin sensitivity in type 2 diabetic patients
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