1,721,020 research outputs found
Cognitive auditory evoked potentials in coma: Can you hear me?
No full textThis scientific commentary refers to 'Neural detection of complex sound sequences in the absence of consciousness', by Tzovara et al
Preliminary observations on the effect of hypoxic and hyperbaric stress on pulmonary gas exchange in breath-hold divers
No full textAim: To evaluate pulmonary alveolar-capillary membrane integrity and ventilation/perfusion mismatch after breath-hold diving. Methods: Pulmonary diffusing capacity to carbon monoxide (DLCO) and nitric oxide (DLNO), haemoglobin (Hb) and haematocrit (Hct) were measured in six elite divers before and at 2, 10 and 25 minutes after a maximal breath-hold dive to a depth of 10 metres' sea water. Results: Compared to pre-dive, DLCO showed a slight increase at 2 minutes in five subjects and a tendency to decrease at 25 minutes (P < 0.001) in all subjects. DLNO showed an increase at 10 minutes in three divers and a slight decrease at 25 minutes in five subjects. There was a small but significant (P < 0.001) increase in Hb and Hct at 2 minutes, possibly affecting the DLCO measurements. Conclusions: An early but transient increase in DLCO in five divers may reflect the central shift in blood volume during a breath-hold dive. The late parallel decrease in DLCO and DLNO likely reflects alveolar-capillary distress (interstitial oedema). The DLNO increase in three subjects at 10 minutes may suggest ventilation/perfusion mismatch
How stress affects slow wave sleep: preliminary suggestions from the simulation of the human flight to Mars (MARS 500 project)
No full textEffect of multichannel transcranial direct current stimulation to reduce hypertonia in individuals with prolonged disorders of consciousness: A randomized controlled pilot study
No full textBackground: Spasticity management in severely brain-injured patients with disorders of consciousness (DOC) is a major challenge because it leads to complications and severe pain that can seriously affect quality of life. Objectives: We aimed to determine the feasibility of a single session of transcranial direct current stimulations (tDCS) to reduce spasticity in chronic patients with DOC. Methods: We enrolled 14 patients in this double-blind, sham-controlled randomized crossover pilot study. Two cathodes were placed over the left and right primary motor cortex and 2 anodes over the left and right prefrontal cortex. Hypertonia of the upper limbs and level of consciousness were assessed by the Modified Ashworth Scale (MAS) and the Coma Recovery Scale-Revised (CRS-R). Resting state electroencephalography was also performed. Results: At the group level, spasticity was reduced in only finger flexors. Four responders (29%) showed reduced hypertonicity in at least 2 joints after active but not sham stimulation. We found no behavioural changes by the CRS-R total score. At the group level, connectivity values in beta2 were higher with active versus sham stimulation. Relative power in the theta band and connectivity in the beta band were higher for responders than non-responders after the active stimulation. Conclusion: This pilot study highlights the potential benefit of using tDCS for reducing upper-limb hypertonia in patients with chronic DOC. Large-sample clinical trials are needed to optimize and validate the technique
Local Gamma Activity During Non-REM Sleep in the Context of Sensory Evoked K-Complexes
Full text linkK-complexes (KCs) and Sleep Slow Oscillations (SSOs) are the EEG expression of neuronal bistability during deeper stages Non-REM sleep. They are characterized by a deep negative deflection lasting about half-a-second, sustained, at the cortical level, by a widespread and synchronized neuronal hyperpolarization (i.e., electrical silence). The phase of hyperpolarization is followed by a period of intense and synchronized neuronal firing (i.e., depolarization phase) resulting at the EEG level, in a large positive deflection (lasting about 0.5 s) and a concurrent high frequency activity (i.e., spindles). Both KCs and SSOs rather than being “local” phenomena, propagate over large sections of the cortex. These features suggest that bistability is a large-scale network phenomenon, possibly driven by a propagating excitatory activity and involving wide populations of synchronized neurons. We have recently shown that KCs and SSOs include a positive bump preceding the negative peak and that for sensory-evoked KCs this bump coincides with the P200 wave. We demonstrated that the P200 has a sensory-modality specific localization, as it is firstly elicited in the primary sensory areas related to the stimulus, which in turn receive projections from the thalamic core. We observed that the P200 acts as a propagating excitatory activity and hypothesized that it could play a key role in inducing the opening of K+ channels, and hence the cortical hyperpolarization. Here we demonstrate that the P200 is sustained by a high-frequency excitation bringing further support to its role in triggering bistability. We show that the P200 has a higher power density in gamma band as compared to the P900 coherently for all sensory modalities, and we confirm that the latter wave is crowned by higher activity in sigma-beta bands. Finally, we characterize the P200 gamma activity at the cortical level in terms of spatial localization and temporal dynamics, demonstrating that it emerges in sensory stimulus-specific primary areas and travels over the cortical mantle spreading toward fronto-central associative areas and fading concurrently with the N550 onset
Neural Correlates of Non-ordinary States of Consciousness in Pranayama Practitioners: The Role of Slow Nasal Breathing
Full text linkThe modulatory effect of nasal respiration on integrative brain functions and hence consciousness has recently been unambiguously demonstrated. This effect is sustained by the olfactory epithelium mechanical sensitivity complemented by the existence of massive projections between the olfactory bulb and the prefrontal cortex. However, studies on slow nasal breathing (SNB) in the context of contemplative practices have sustained the fundamental role of respiratory vagal stimulation, with little attention to the contribution of the olfactory epithelium mechanical stimulation. This study aims at disentangling the effects of olfactory epithelium stimulation (proper of nasal breathing) from those related to respiratory vagal stimulation (common to slow nasal and mouth breathing). We investigated the psychophysiological (cardio-respiratory and electroencephalographic parameters) and phenomenological (perceived state of consciousness) aftereffects of SNB (epithelium mechanical – 2.5 breaths/min) in 12 experienced meditators. We compared the nasal breathing aftereffects with those observed after a session of mouth breathing at the same respiratory rate and with those related to a resting state condition. SNB induced (1) slowing of electroencephalography (EEG) activities (delta-theta bands) in prefrontal regions, (2) a widespread increase of theta and high-beta connectivity complemented by an increase of phase-amplitude coupling between the two bands in prefrontal and posterior regions belonging to the Default Mode Network, (3) an increase of high-beta networks small-worldness. (4) a higher perception of being in a non-ordinary state of consciousness. The emerging scenario strongly suggests that the effects of SNB, beyond the relative contribution of vagal stimulation, are mainly ascribable to olfactory epithelium stimulation. In conclusion, slow Pranayama breathing modulates brain activity and hence subjective experience up to the point of inducing a non-ordinary state of consciousness
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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