1,721,018 research outputs found
The Burma-Bucknell Connection
No full textMy project looks at the historical connection between Bucknell and Burma, where Shaw Loo, Bucknell’s first International Student came from. Through the years, there have been numerous events like the Burma-Bucknell Weekends and attempts to keep the connection alive that have been scattered and not easily available to the general public. My goal this summer was to compile the information available and fill in any gaps in the narrative.
Over the summer, I primarily found my information in the Special Collections and University Archives of the Bertrand Library. I then used Scalar to compile my information in a mixture of text, pictures, and videos to tell a linear story. I also compiled all related documents from the archives on Omeka for readers to browse through.
This project was done in the hopes that it will spark more interest in Burma, and in the international relationships that not only Bucknell but also other schools have with the countries of their international students
Minimal dataset for the research "Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis"
No full text<p><strong>Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis:</strong></p><p><strong>Latest Version Published: </strong>22 Jun 2023, <strong>8</strong>:272 (<a href="https://doi.org/10.12688/wellcomeopenres.19275.1">https://doi.org/10.12688/wellcomeopenres.19275.1</a>)</p><p>This is an open access work distributed under the terms of the <a href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
Defining the optimal management of Plasmodium falciparum malaria on a background of emerging artemisinin combination therapy resistance
Get PDFDrug resistant falciparum malaria has emerged twice from the Thai-Cambodian border and spread to the rest of the globe with disastrous consequences. The deployment of artemisinin-based combination therapy (ACT) as first-line treatment for P. falciparum malaria has reduced the burden of malaria dramatically worldwide and reignited the interest in the goal of malaria elimination. However, slow-clearing parasites resistant to artemisinin are emerging across the Greater Mekong Sub-region eventually leading to the failure of the ACTs.
One objective of this thesis was to determine the association between therapeutic efficacy of one of the first line ACTs (mefloquine-artesunate) and the drug-resistant molecular markers for the constituent drugs (Pfmdr-1 and K-13 mutations). Between 2003 and 2013, the adequate clinical and parasitological response to mefloquine-artesunate declined from 100% to 81.1% as the proportions of isolates with multiple Pfmdr-1 copies doubled from 32.4% to 64.7% and those with K-13 mutations increased from 6.7% to 83.4%. Detailed investigations of the various K-13 polymorphisms revealed that along the ThailandâMyanmar border, the fittest alleles (C580Y) are taking over from less resistant or less fit ones.
The second objective of this thesis was to evaluate new antimalarials (OZ439, a synthetic peroxide structurally related to artemisinin; KAE609, a spironindolone; and KAF156, an imidazolopiperazine, both are structurally novel molecules) in Phase 2a proof-of-concept studies. Parasitological efficacy was evaluated by measuring parasite clearance half-life. In all trialled doses of OZ439, KAE609 and KAF156 parasite clearance half-lives were not different in patients with artemisinin-sensitive and artemisinin-resistant parasites. No serious drug-related adverse effects were reported and these compounds will move into Phase 2b studies in late 2016.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Clinical impact of vivax malaria: a collection review
Get PDFBackground
Plasmodium vivax infects an estimated 7 million people every year. Previously, vivax malaria was perceived as a benign condition, particularly when compared to falciparum malaria. Reports of the severe clinical impacts of vivax malaria have been increasing over the last decade.
Methods and findings
We describe the main clinical impacts of vivax malaria, incorporating a rapid systematic review of severe disease with meta-analysis of data from studies with clearly defined denominators, stratified by hospitalization status. Severe anemia is a serious consequence of relapsing infections in children in endemic areas, in whom vivax malaria causes increased morbidity and mortality and impaired school performance. P. vivax infection in pregnancy is associated with maternal anemia, prematurity, fetal loss, and low birth weight. More than 11,658 patients with severe vivax malaria have been reported since 1929, with 15,954 manifestations of severe malaria, of which only 7,157 (45%) conformed to the World Health Organization (WHO) diagnostic criteria. Out of 423 articles, 311 (74%) were published since 2010. In a random-effects meta-analysis of 85 studies, 68 of which were in hospitalized patients with vivax malaria, we estimated the proportion of patients with WHO-defined severe disease as 0.7% [95% confidence interval (CI) 0.19% to 2.57%] in all patients with vivax malaria and 7.11% [95% CI 4.30% to 11.55%] in hospitalized patients. We estimated the mortality from vivax malaria as 0.01% [95% CI 0.00% to 0.07%] in all patients and 0.56% [95% CI 0.35% to 0.92%] in hospital settings. WHO-defined cerebral, respiratory, and renal severe complications were generally estimated to occur in fewer than 0.5% patients in all included studies. Limitations of this review include the observational nature and small size of most of the studies of severe vivax malaria, high heterogeneity of included studies which were predominantly in hospitalized patients (who were therefore more likely to be severely unwell), and high risk of bias including small study effects.
Conclusions
Young children and pregnant women are particularly vulnerable to adverse clinical impacts of vivax malaria, and preventing infections and relapse in this groups is a priority. Substantial evidence of severe presentations of vivax malaria has accrued over the last 10 years, but reporting is inconsistent. There are major knowledge gaps, for example, limited understanding of the underlying pathophysiology and the reason for the heterogenous geographical distribution of reported complications. An adapted case definition of severe vivax malaria would facilitate surveillance and future research to better understand this condition
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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