170,242 research outputs found
Die Chronfk Johanns von Winterthur. In Verbindung mit C. Brun herausgegeben von Friedrich Baethgen, 1924
No full textPfleger Lucien. Die Chronfk Johanns von Winterthur. In Verbindung mit C. Brun herausgegeben von Friedrich Baethgen, 1924. In: Revue des Sciences Religieuses, tome 6, fascicule 2, 1926. pp. 293-294
Cell-cycle regulation of the p53-inducible gene B99
No full textAbstractB99 is a p53-inducible gene whose accumulation upon p53 activation is restricted to late S/G2 cells. Here we have analyzed B99 regulation during the cell cycle in murine cells with or without functional p53. We report that B99 accumulates in late S/G2 phase, is phosphorylated in mitosis, and disappears in G1 phase, regardless of the status of p53. As a complement to this observation, we show that B99 is not induced by p53 in quiescent cells. Therefore, B99 expression is modulated both by cell-cycle regulatory mechanisms and by p53, and p53 can increase the cellular levels of B99 only during the window of the cell cycle when it is normally expressed. On the basis of these observations we rename B99 Gtse-1 (G-two- and S-phase-expressed)
Fungicides for the home garden (Revised 1975)
No full text1 online resource (PDF, 2 pages)This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.Stienstra, Ward C.; Pfleger, F. L.. (1975). Fungicides for the home garden (Revised 1975). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/207189
Fungicides for the home garden (Revised 1981)
No full text1 online resource (PDF, 2 pages)This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.Stienstra, Ward C.; Pfleger, F. L.. (1981). Fungicides for the home garden (Revised 1981). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/207188
Gladiolus diseases (Revised 1975)
No full text1 online resource (PDF, 2 pages)This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.Stienstra, Ward C.; Pfleger, F. L.. (1975). Gladiolus diseases (Revised 1975). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/207183
Rose diseases (Revised 1976)
No full text1 online resource (PDF, 2 pages)This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.Stienstra, Ward C.; Pfleger, F. L.. (1976). Rose diseases (Revised 1976). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/207198
Diseases of peony (Revised 1975)
No full text1 online resource (PDF, 2 pages)This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.Stienstra, Ward C.; Pfleger, F. L.. (1975). Diseases of peony (Revised 1975). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/207182
Association of adiponectin, interleukin (IL)-1ra, inducible protein 10, IL-6 and number of islet autoantibodies with progression patterns of type 1 diabetes the first year after diagnosis
No full textThe progression of type 1 diabetes after diagnosis is poorly understood. Our aim was to assess the relation of disease progression of juvenile-onset type 1 diabetes, determined by preserved beta cell function the first year after diagnosis, with systemic cytokine concentrations and number of autoantibodies. Juvenile patients (n = 227) had a meal-stimulated C-peptide test 1 and 6 months after diagnosis. On the basis of the C-peptide course for the duration of 1-6 months, four progression groups were defined: patients with persistently low beta cell function ('stable-low'), rapid progressers, slow progressers and remitters. Serum concentrations of adiponectin, interleukin (IL)-1ra, inducible protein 10 (IP-10), IL-6 and glutamic acid decarboxylase (GAD), IA-2A and islet-cell antibodies (ICA) were measured at 1, 6 and 12 months. We found that adiponectin concentrations at 1 month predicted disease progression at 6 months (P = 0·04). Patients with low adiponectin had a higher probability of becoming remitters than rapid progressers, odds ratio 3·1 (1·3-7·6). At 6 and 12 months, adiponectin differed significantly between the groups, with highest concentrations among stable-low and rapid progressers patients (P = 0·03 and P = 0·006). IL-1ra, IP-10 and IL-6 did not differ between the groups at any time-point. The number of autoantibodies differed significantly between the groups at 1 month (P = 0·04), where rapid progressers had the largest number. There was no difference between the groups in human leucocyte antigen-associated risk. We define progression patterns distinguishing patients diagnosed with low beta cell function from those with rapid decline, slow decline or actual increase in beta cell function, pointing to different mechanisms of disease progression. We find that adiponectin concentration at 1 month predicts, and at 6 and 12 months associates with, distinct progression patterns
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