177,286 research outputs found
Speed of collapse of the non-ventilated lung during single-lung ventilation for thoracoscopic surgery: the effect of transient increases in pleural pressure on the venting of gas from the non-ventilated lung
No full textJ. Pfitzner, M. J. Peacock, R. J. D. Harri
Palestrina(1917) de Hans Pfitzner : un opéra à la charnière de deux époques
No full textLa légende en trois actes, Palestrina, de Hans Pfitzner est, comme le remarque Thomas Mann à juste titre dans ses Considérations d’un apolitique, « le dernier écho et, consciemment, l’ultime de la sphère schopenhauerienne-wagnérienne ». Pfitzner se définit lui-même comme un héritier d’une longue tradition qu’il voit menacée par les bouleversements artistiques et politiques que connaît le début du xxe siècle et il déplore, comme Thomas Mann dans son œuvre conservatrice, le finis musicae ; ceci notamment dans sa polémique contre Ferruccio Busoni au titre évocateur de Danger futuriste (1917) dans laquelle on retrouve certaines positions de l’opéra Palestrina. Palestrina fait partie du genre littéraire du Künstlerdrama dont Pfitzner reprend le thème principal depuis Goethe, l’opposition entre art et vie, en s’appuyant sur la philosophie schopenhauerienne. Contrairement à ses prédécesseurs, Pfitzner décrit dans Palestrina l’antagonisme entre art et vie avec une dureté implacable. Palestrina, le musicien du xvie siècle que le siècle suivant a surnommé le « Sauveur de la Musique », s’avère être un personnage typique d’une « situation culturelle tardive » (R. Seebohm). Sa réponse aux bouleversements de son temps s’exprime par un attachement sans faille aux grands compositeurs du passé, sachant qu’il se situe lui-même « à la fin d’une grande époque ».Pfitzners Legende in drei Akten, Palestrina, ist, wie Thomas Mann in seinen Betrachtungen eines Unpolitischen zu Recht bemerkt, «etwas Letztes und mit Bewußtsein Letztes aus der schopenhauerisch-wagnerischen» Sphäre. Pfitzner definiert sich selbst als Spätgeborener und Erbe einer jahrhundertelangen Tradition, die er durch die künstlerischen Umwälzungen am Anfang des 20. Jahrhunderts gefährdet sieht und er beklagt, wie Thomas Mann auch in seiner konservativen Schrift, das finis musicae, so u. a. in seiner Polemik gegen Ferruccio Busoni Futuristengefahr (1917), in der wir Positionen wiederfinden, die er in seinem Palestrina eingenommen hat. Geistesgeschichtlich gehört Palestrina zu der Gattung des Künstlerdramas, dessen Hauptthema, den Widerspruch zwischen Kunst und Leben, Pfitzner in der Nachfolge Schopenhauers aufgreift. Im Verhältnis zu seinen Vorgängern behandelt jedoch dieses späte Künstlerdrama den Kunst-und-Leben-Antagonismus mit unversöhnlicher Härte. Palestrina, die Musikergestalt aus dem 16. Jahrhundert, den man seit dem 17. Jahrhundert den «Retter der Musik» genannt hat, erweist sich als eine typische Figur einer Übergangzeit und einer «Spätkultursituation» (R. Seebohm). Seine Antwort auf die Umwälzungen seiner Zeit ist eine Rückwärtsgewandtheit, die ihn jedoch nicht daran hindert, im Bewußtsein ein Letzter zu sein und am «Ende einer grossen Zeit» zu stehen, Großes zu leisten
Zur Verortung des Konzeptes der "Potenzialorientierten Förderung" in den sozialwissenschaftlichen Fachdidaktiken - am Beispiel der Berufsorientierung
No full textZurstrassen B. Zur Verortung des Konzeptes der "Potenzialorientierten Förderung" in den sozialwissenschaftlichen Fachdidaktiken - am Beispiel der Berufsorientierung. In: Veber M, Benölken R, Pfitzner M, eds. Potenzialorientierte Förderung in den Fachdidaktiken. Begabungsförderung: Individuelle Förderung und Inklusive Bildung. Vol 7. Münster: Waxmann; 2019: 135-149
Tobacco TGA factors differ with respect to interaction with NPR1, activation potential and DNA-binding properties
No full textIn higher plants, as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Originally found in viral and T-DNA promoters, they are also functional elements of plant promoters activated during the defence response against pathogens. Tobacco bZIP transcription factor TGA1a was the first recombinant protein shown to bind to as-1. cDNAs for two novel tobacco as-1-binding bZIP proteins (TGA2.1 and TGA2.2) were isolated. Revealing a high degree of amino acid identity in the bZIP domain (89%) and the C-terminus (79%), the two TGA2 factors differ remarkably with respect to the length of the N-terminus (170 amino acids in TGA2.1 versus 43 amino acids in TGA2.2). TGA2.1 and TGA2.2, but not TGA1a, interacted with ankyrin repeat protein NPR1, a central activator of the plant defence response. In contrast, TGA2.1 and TGA1a, but not TGA2.2, functioned as transcriptional activators in yeast. Apart from conferring transcriptional activation, the N-terminal domain of TGA2.1 led to reduced in vitro as-1-binding activity and almost completely abolished binding to one half site of this bifunctional element. When being part of a heterodimer with TGA2.2, TGA2.1 was efficiently recruited to a single half site, though double occupancy of the element was still preferred. In contrast, TGA1a preferred to bind to only one palindrome, a feature that was also maintained in heterodimers between TGA1a and TGA2.1 or TGA2.2
Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis
No full textThe Arabidopsis thaliana NONEXPRESSER OF PR GENES1 (NPR1, also known as NIM1) protein is an essential positive regulator of salicylic acid (SA)-induced PATHOGENESIS-RELATED (PR) gene expression and systemic acquired resistance (SAR). PR gene activity is regulated at the level of redox-dependent nuclear transport of NPR1. NPR1 interacts with members of the TGA family of transcription factors that are known to bind to SA-responsive elements in the PR-1 promoter. In an attempt to identify proteins involved in SA-mediated signal transduction, we previously described the isolation of three novel genes encoding distinct albeit structurally related proteins designated NIMIN1 (for NIM11-INTERACTING1), NIMIN2, and NIMIN3 that interact with NPR1 in the yeast two-hybrid system. Here,we show that NIMIN1 and NPR1 can be copurified from plant extracts, providing biochemical evidence for their interaction. We provide functional evidence for this interaction by describing transgenic plants constitutively expressing high amounts of NIMIN1. These plants show reduced SA-mediated PR gene induction and a compromised SAR, thus mimicking the described phenotype conferred by npr1. Moreover, they showed reduced RESISTANCE gene-mediated protection. These effects were dependent on the ability of NIMIN1 to interact with NPR1. Mutant plants with a T-DNA insertion in NIMIN1 as well as transgenic plants with reduced NIMIN1 mRNA levels showed hyperactivation of PR-1 gene expression after SA treatment but no effect on the disease resistance phenotype. Our results strongly suggest that NIMIN1 negatively regulates distinct functions of NPR1, providing a mechanism to modulate specific features of SAR
Association of environmental factors and the stress level among slum dwellers-a cross sectional study in the megacity Dhaka, Bangladesh
No full textSpallek L, Pfitzner R, Kernebeck S, Krämer A, Khan MH. Association of environmental factors and the stress level among slum dwellers-a cross sectional study in the megacity Dhaka, Bangladesh. The European Journal of Public Health. 2012;22(Suppl. 2):276-277
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Die Perspektive wechseln – Forschendes Lernen im Praxissemester Sport
No full textUkley N, Nocon-Stoffers R, Roth A-C, Pfitzner M. Die Perspektive wechseln – Forschendes Lernen im Praxissemester Sport. In: Peuker B, Busker M, Rautenstrauch H, Winkel J, eds. Forschendes Lernen in der fach- und fachrichtungsbezogenen, universitären Lehrkräftebildung. Darmstadt: wbg Academic; 2023: 254-263
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