1,720,990 research outputs found
Planetary entropy production as a thermodynamic constraint for exoplanet habitability
Full text linkAny biosphere emerges, lives, and grows producing entropy. Entropy production is a thermodynamic function crucial in the framework of non-equilibrium thermodynamics as it is directly related to the dynamical behaviour of far-from equilibrium systems. The extent of entropy production is proportional to the ability of such systems to dissipate free energy and thus to ‘live’, to evolve, to grow in complexity. Generally, a certain threshold of entropy production must be exceeded for the emergence of complex self-organizing structures. Thus, the entropy production can be considered as the thermodynamic thrust that drives life emergence and evolution. In this perspective, we propose that the value of the planetary entropy production (PEP) can provide a first order estimate of the thermodynamic potential of planetary environment to sustain a complex biosphere. Here we use a simplified approach to evaluate the upper limit to the PEP and to the corresponding free energy as function of stellar temperature and orbital parameters of the planet. We found that only Earth-like planets in the circumstellar habitable zone (CHZ) of G and F stars can have a PEP value higher than the Earth value. Further significant thermodynamic differences exist between the inner and outer edge of the CHZ, with the inner edge being thermodynamically more advantageous for the development of complex biospheres. Interestingly, among the recently proposed habitable exoplanets, the ones belonging to the Hycean planets appear the thermodynamically best candidates
KRAS promoter G-quadruplexes from sequences of different length: A physicochemical study
No full textDNA G-quadruplexes (G4s) form in relevant genomic regions and intervene in several biological processes, including the modulation of oncogenes expression, and are potential anticancer drug targets. The human KRAS proto-oncogene promoter region contains guanine-rich sequences able to fold into G4 structures. Here, by using circular dichroism and differential scanning calorimetry as complementary physicochemical methodologies, we compared the thermodynamic stability of the G4s formed by a shorter and a longer version of the KRAS promoter sequence, namely 5′-AGGGCGGTGTGGGAATAGGGAA-3′ (KRAS 22RT) and 5′-AGGGCGGTGTGGGAAGAGGGAAGAGGGGGAGG-3′ (KRAS 32R). Our results show that the unfolding mechanism of KRAS 32R is more complex than that of KRAS 22RT. The different thermodynamic stability is discussed based on the recently determined NMR structures. The binding properties of TMPyP4 and BRACO-19, two well-known G4-targeting anticancer compounds, to the KRAS G4s were also investigated. The present physicochemical study aims to help in choosing the best G4 target for potential anticancer drugs
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Encapsulating properties of sulfobutylether-β-cyclodextrin toward a thrombin-derived antimicrobial peptide
No full textThe pharmacological application of antimicrobial peptides (AMPs) is seriously limited as they are not chemically and
physically stable. Their encapsulation could represent a way to protect AMPs improving their pharmacological properties.
In this study, the complex between the sulfobutylether-b-cyclodextrin (SBE-b-CD) and the antimicrobial peptide
(P)GKY20 and its effect on a lipid bilayer have been characterized by a combination of calorimetric (ITC, DSC) and
spectroscopic (fluorescence, Circular Dichroism) techniques. The results obtained indicate that the (P)GKY20 form a 1:1
inclusion complex with the anionic SBE-b-CD. Our ITC experiments revealed that the interaction process is entropically
driven and that the enthalpy change only slightly contributes to the free energy change. Finally, differential scanning
calorimetry data revealed that the peptide, even in the presence of SBE-b-CD, is still able to perturb the bacterial model
membrane composed of DPPC/DPPG (8/2 mol mol-1). This work demonstrated that, in principle, SBE-b-CD could be
used as efficient encapsulating agent for the (P)GKY20 or other antimicrobial peptides, rendering possible their pharmacological
applications
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