103 research outputs found
ERRATUM: Repetitive recombinant human bone morphogenetic protein 2 injections improve the callus microarchitecture and mechanical stiffness in a sheep model of distraction osteogenesis
No full textDue to a technical error, Dr. Marc-Frederic Pastor was omitted from the author list of this article. The correct author details appear above.<br /
“I am not joking” : a reconsideration on Frederic Henry and the lovely critics who laugh at him.
No full textAlmost no other American author is critically revered and equally dismissed as Ernest Hemingway. This essay surveys the prevailing critical views of the protagonists in A Farewell to Arms and investigates how these views have inhibited our understanding of the individual characters. By exploring the similarities in the male and female protagonists' scholarships, this essay takes up the question of critical determinism in Frederic Henry’s scholarship. I analyze Hemingway’s construction of his male protagonist’s sense of humour and show how it reveals a contrasting portrait of Frederic Henry compared to the portrait we derive of him from his critical scholarship. This essay addresses on the prevailing biases against Frederic Henry in current scholarship. I suggest that present critics fail to appreciate Frederic Henry’s positive attributes because they view Catherine Barkley as an opposition to Frederic Henry. I will also briefly study Frederic Henry’s use of black humour during the couple’s escape to Switzerland because compared to Catherine Barkley his humour is not critically acknowledged as one of the strengths of his character. Instead of laughing at Frederic Henry, present Hemingway scholars should bequeath irony and pity on Frederic Henry and reassess his critical identity in Hemingway scholarship.Bachelor of Art
Consciousness as Recursive, Spatiotemporal Self-Location
No full textAt the phenomenal level, consciousness arises in a consistently coherent fashion as a singular, unified field of recursive self-awareness (subjectivity) with explicitly orientational characteristics—that of a subject located both spatially and temporally in an egocentrically-extended domain. Understanding these twin elements of consciousness begins with the recognition that ultimately (and most primitively), cognitive systems serve the biological self-regulatory regime in which they subsist. The psychological structures supporting self-located subjectivity involve an evolutionary elaboration of the two basic elements necessary for extending self-regulation into behavioral interaction with the environment: an orientative reference frame which consistently structures ongoing interaction in terms of controllable spatiotemporal parameters, and processing architecture that relates behavior to homeostatic needs via feedback. Over time, constant evolutionary pressures for energy efficiency have encouraged the emergence of anticipative feedforward processing mechanisms, and the elaboration, at the apex of the sensorimotor processing hierarchy, of self-activating, highly attenuated recursively-feedforward circuitry processing the basic orientational schema independent of external action output. As the primary reference frame of active waking cognition, this recursive self-locational schema processing generates a zone of subjective self-awareness in terms of which it feels like something to be oneself here and now. This is consciousness-as-subjectivity
05-08-2017 Interactive Exhibit at Washita Battlefield Site Nominated for Awards
No full textSWOSU faculty Dr. Siriporn Peters and Frederic Murray were two of several that helped develop an interactive exhibit at the Washita Battlefield National Historic Site. The exhibit was nominated this spring for two National Park Service Awards.https://dc.swosu.edu/barkpic17/1166/thumbnail.jp
Theories of Consciousness as Reflexivity
No full textConsciousness is best understood in context, as one element of an interactive waking state in which the greater part of cognitive processing takes place in a nonconscious fashion. But if conscious and nonconscious processing are combined in the waking state, what distinguishes the former form the latter, what is consciousness, and what is its purpose? The answer to the second question depends crucially on our conclusion regarding the first. What is the property in virtue of which a state is conscious rather than nonconscious? In the following, it will be argued that of the answers most frequently proposed—intentionality, subjectivity, accessibility, reflexivity—only the final characteristic, reflexive, autonoetic awareness, is unique to the conscious state. Reflexivity can best be explained not as the product of a self-representational data structure, but as the expression of a recursive processing regime, in which cognition registers the properties of the processing state to a greater extent than properties of the content represented. And the principal characteristic of a reflexive processing state is cognitive reflexivity or autonoetic awarenes
The discovery of SycO reveals a new function for type three secretion effector chaperones
No full textThe Type Three Secretion (T3S) system is a device used by many Gram-negative pathogens that allows bacteria to deliver effector proteins straight into the eukaryotic cell cytosol. These effectors interfere with various signaling pathways to subvert the host cell functions. The secretion machinery of the T3S system consist of a basal body spanning the bacterial inner and outer membrane followed by a stiff hollow needle outside the bacterium. The fully assembled secretion apparatus constitute a continuous hollow conduit that connects the bacteria to the eukaryotic target cell. After cell contact, virulence proteins -called effectors- are injected directly into the cytosol of the host cell via the T3S apparatus. Several effectors of the T3S system require the assistance of specific cytosolic chaperones to be efficiently exported. There are three classes of T3S chaperones. Effector proteins are assisted by Class I chaperones. Although Class I chaperones are well characterized, their main function is still a matter of controversy. In this thesis, we demonstrate that orf155 encodes a specific chaperone for the effector YopO that we called SycO. We showed that SycO enhances YopO secretion in vitro and is required for translocation of YopO into infected cells. By pulldown assay we demonstrated that residues 20 to 77 of YopO are required and sufficient for SycO binding. Using crosslinking experiments and size exclusion chromatography analysis, we determined the stoichiometry of purified SycO and YopO-SycO complexes. SycO alone forms dimers in solution and the YopO-SycO complex has a 1:2 stoichiometry. These results suggested that SycO is a typical chaperone of the Class I. YopO is a serine/theronine kinase that interacts with Rho and Rac and disrupts the cytoskeleton of the target cells. YopO has been shown to localize at the cell plasma-membrane. By transfection of YopO-EGFP hybrid proteins into HEK293T cells, we demonstrated that the chaperone-binding domain (CBD) coincides with the membrane localization domain of YopO. Nevertheless, the CBD was not needed for the kinase activity of YopO. By ultracentrifugation, we also showed that the CBD causes YopO aggregation in the bacteria, when SycO does not cover it. Further, we show that the CBD of YopE and YopT also caused aggregation in the bacteria in the absence of SycE and SycT respectively. YopE, YopT and T3S effectors in other systems also act at the membrane of the eukaryotic host cell. We propose a new hypothesis concerning the role of T3S chaperones. The sub-cellular localization domain of effectors is aggregation-prone and creates the need for a chaperone inside bacteria. We propose that masking such aggregation-prone localization domains may be a general function for type III effector chaperones
Book briefs: Seduction of the innocent
No full textDr. Frederic Wertham\u27s book Seduction of the Innocent reviews the harmful effects of crime comics in children. In the book the author claims that crime comics consist of 50 to 100 frames of brutality, violence and blood, sexual sadism, a distorted view of authority, womanhood and life, and can also adversely affect a child\u27s reading ability. The author calls for a ban on crime comics for children under the age of 15
John Gay's the beggar's opera: early eighteenth-century responses in the arts to cultural, sociological and political issues in London life
No full textDiffering responses in art media to these contemporary issues of London life are explored, taking John Gay's the Beggar's Opera as the focal point for discussion. Initially, a general survey is made of Gay's role as cultural, social and moral critic. Comparison with George Frederick Handel's Floridante allows Gay's work to be placed in the context of operatic responses to contemporary society, highlighting usage both of overt portrayal and indirect satire. Gay's approach to political issues is examined alongside that of Dean Swift's Gulliver's Travels enabling an estimation to be made of the effectiveness of these art media as tools of political propaganda. Similarly, responses in the field of painting are discussed in the light of representative works of James Thornhill and William Hogarth's A Harlot's Progress and A Rake's Progress. In considering all these responses it is noted that art can be interpreted at differing levels, from the sophisticated to the naive. All these art media are then placed in the context of artistic philosophy of the period, thus facilitating an objective assessment of the parallels and differences of art's responses to contemporary issues. Taking into account inherent limitations in the media, to conclude our study, Hogarth's The Beggar's Opera Scenes are compared and contrasted with Gay's prototype. The thesis highlights the trend towards realism in the arts during this period. Nevertheless, we are left with the conundrum that art, 'per se', can only 'mirror' life. It does not necessarily solve its problems. Thesis submitted in fulfilment of the requirements for the degree of Master of Arts in Music. University of Durham Department of Music 198
Testing a simple structure hypothesis in factor analysis
No full textIt is assumed that the investigator has set up a simple structure hypothesis in the sense that he has specified the zero loadings of the factor matrix. The maximum-likelihood method is used to estimate the factor matrix and the factor correlation matrix directly without the use of rotation methods, and the likelihood-ratio technique is used to test the simple structure hypothesis. Numerical examples are presented.The work was supported by a grant (NSF-GB 1985) from the National Science Foundation to Educational Testing Service. Reproduction in whole or in part for any purpose of the United States Government is permitted.The work was carried out when the author was Visiting Research Statistician at Educational Testing Service. The author wishes to thank Dr. Frederic M. Lord for many helpful suggestions throughout the course of this study.</p
Perspectives on environmental assessment in Yukon: A collection of essays
No full textEnvironmental and socio-economic effects assessment ensures that the effects of development activities are considered before they happen and that significant adverse effects will be mitigated. Dr. Amelie Janin, NSERC Industrial Research Chair in Mine Life Cycle at Yukon College taught this course over the Winter 2017. Through discussions with a series of guest speakers and with the instructor, the students were tasked to reflect on the environmental assessment process in Yukon and to write short essays. The essays have been compiled under one document.Contributions by students from the RRMT238/RENR307 Winter 2017 cours
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