189 research outputs found
EFFECTS OF THE S-ADENOSYLHOMOCYSTEINE HYDROLASE INHIBITORS 3-DEAZAADENOSINE AND 3-DEAZAARISTEROMYCIN ON RNA METHYLATION AND SYNTHESIS
No full textThe effects of 3-deazaaristeromycin and 3-deazaadenosine on RNA methylation and synthesis were examined in the mouse macrophage cell line, RAW264. S-Adenosylhomocysteine accumulated in cells incubated with 3-deazaaristeromycin while S-3-deazaadenosylhomocysteine was the major product in cells incubated with 3-deazaadenosine and homocysteine thiolactone. RNA methylation was inhibited to a similar extent by the accumulation of either S-adenosylhomocysteine or S-3-deazaadenosylhomocysteine, with S-adenosylhomocysteine being a slightly better inhibitor. In mRNA, the synthesis of N6-methyladenosine and N6-methyladenosine and N6-methyl-2'-O-methyladenosine were inhibited to the greatest extent, while the synthesis of 7-methylguanosine and 2'-O-methyl nucleosides were inhibited to a lesser extent. Incubation of cells with 100 μM 3-deazaaristeromycin or with 10 μM 3-deazaadenosine and 50 μM homocysteine thiolactone produced little inhibition of mRNA synthesis, even though mRNA methylation was inhibited. In contrast, mRNA synthesis was greatly inhibited by treatment of cells with 100 μM 3-deazaadenosine and the inhibition of synthesis was not correlated with an inhibition of methylation
Complex sine-Gordon theory: solitons, defects and boundaries
No full textThis thesis presents research into the properties and features of the complex sine- Gordon theory. The CSG theory is a dimensional integrable held theory that admits soliton solutions which carry a Noether charge due to the U(I) invariance of the theory. Integrable CSG defects and boundaries are constructed and interactions between solitons, defects and boundaries are analysed at the classical and quantum level. The introduction of defects into the theory is facilitated by a new Backlund transformation involving two parameters. Defect conditions, constructed so they maintain the integrability of the theory and found to be exactly the BT, are used to sew two CSG theories together. How solitons interact with the defect is investigated, in particular whether as in the SG theory solitons can be absorbed and emitted by the defect. The classical time-delay and phase-shift are calculated for soliton-defect and particle-defect scattering. Using the CSG defect to dress the Dirichlet boundary a new CSG boundary theory is produced. Its integrability is checked by the explicit construction of conserved charges. The various interactions between solitons and the boundary are analysed, compared and contrasted with the defect theory. Finally aspects of the quantum CSG boundary theory are examined, culminating in a conjecture for the quantum reflection matrix for a Q = -1-1 soliton reflecting from an unexcited boundary. Reflection and boundary bootstrap procedures are used to generate the general reflection matrix for any charged soliton reflecting from any excited boundar
Training young engineers to see
No full textThis case study in the professional education of engineers is based on a Talent Programme at Combitech in Sweden, in association with the Royal Institute of Technology. The approach is based on use of the Dialogue Seminar Method. © 2011 The Author(s).</p
Thirring model with jump defect
No full textThe purpose of our work is to extend the formulation of classical affine Toda Models in the presence of jump defects to pure fermionic Thirring model. As a first attempt we construct the Lagrangian of the Grassmanian Thirring model with jump defect (of Backlund type) and present its conserved modified momentum and energy expressions giving a first indication of its integra-bility. Copyright © owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence
Thirring model with jump defect
No full textThe purpose of our work is to extend the formulation of classical affine Toda Models in the presence of jump defects to pure fermionic Thirring model. As a first attempt we construct the Lagrangian of the Grassmanian Thirring model with jump defect (of Backlund type) and present its conserved modified momentum and energy expressions giving a first indication of its integra-bility. Copyright © owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence
Towards a Sustainable Future: The Dynamic Adjustment Path of Irrigation Technology and Water Management in Western U.S. Agriculture
No full textTechnology adoption, Water conservation, Irrigation, Dynamic groundwater models, Sustainable agriculture, Environmental Economics and Policy, Resource /Energy Economics and Policy,
Periodic and homoclinic solutions of the modified 2+1 chiral model
No full textWe use algebraic Backlund transformations (BTs) to construct explicit solutions of the modified 2+1 chiral model from T(2)xR to SU(n), where T-2 is a 2-torus. Algebraic BTs are parametrized by z is an element of C (poles) and holomorphic maps pi from T-2 to Gr(k,C-n). We apply Backlund transformations with carefully chosen poles and pi's to construct infinitely many solutions of the 2+1 chiral model that are (i) doubly periodic in space variables and periodic in time, i.e., triply periodic, (ii) homoclinic in the sense that the solution u has the same stationary limit u(0) as t ->+/-infinity and is tangent to a stable linear mode of u(0) as t ->infinity and is tangent to an unstable mode of u(0) as t ->-infinity. (C) 2005 American Institute of Physics.Physics, MathematicalSCI(E)1ARTICLE6null4
Serious games design knowledge : Experiences from a decade (+) of serious games development
No full textINTRODUCTION: Serious games is an effort to combine the engagement and motivation from games with some sort of utility beyond mere entertainment. OBJECTIVES: The objective of this paper is to revisit and analyse six projects to explore the design space for serious games and derive design guidelines for serious games. METHODS: We analysed our project portfolio to identify a set of projects which satisfied well-established guidelines for design science research. By analysing these projects as well as their outcomes we generated a set of design principles for serious games. RESULTS: The results from this study is a conceptualisation of the design space for serious games and seven design principles. CONCLUSION: By explicating the game design component in serious games and relating it to the utility dimension we add to the understanding of the serious games from a game perspective, which is relevant to any development effort intending to use the persuasive and motivational power of games.Online first; published on 27 May 2021.CC BY 4.0"Funding has been provided by: University of Skövde, Länsförsäkringar, Sten A Olssons stiftelse för forskning och kultur, Church of Sweden, World Childhood Foundation, Region Västra Götaland, Swedish Rescue Services Agency research fund."Corresponding author: Email: [email protected]</p
Thirring model with jump defect
No full textThe purpose of our work is to extend the formulation of classical affine Toda Models in the presence of jump defects to pure fermionic Thirring model. As a first attempt we construct the Lagrangian of the Grassmanian Thirring model with jump defect (of Backlund type) and present its conserved modified momentum and energy expressions giving a first indication of its integra-bility. Copyright © owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence.Instituto de Física Teórica UNESP, São PauloInstituto de Física Teórica UNESP, São Paul
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