1,669 research outputs found
Shared versus distinct genetic contributions of mental wellbeing with depression and anxiety symptoms in healthy twins
No full textAvailable online 9 July 2016Abstract not availableKylie M. Routledge, Karen L.O. Burton, Leanne M. Williams, Anthony Harris, Peter R. Schofield, C. Richard Clark, Justine M.Gat
Sex differences in the shared genetics of dimensions of self-reported depression and anxiety
No full textAbstract not available.Karen L.O. Burton, Leanne M. Williams, C. Richard Clark, Anthony Harris, Peter R. Schofield, Justine M. Gat
Identification and characterisation of a gene that caus es dementia
No full textA/Pr Peter R Schofield$AUD 233,794.42NHMRC Project GrantsStandard Project Gran
Wolbachia infection suppresses both host defence and parasitoid counter-defence
No full textEndosymbiotic bacteria in the genus Wolbachia have been linked to several types of reproductive parasitism, which enhance their own transmission, while their direct effects on the host vary from beneficial to neutral or detrimental. Here, we report negative effects of infection on immunity-related traits of Drosophila simulans and the parasitoid wasp Leptopilina heterotoma. Infected D. simulans showed a reduced ability to encapsulate parasitoid eggs, compared to a tetracycline-treated, bacterium-free line. Challenging the two lines with a fungal pathogen, Beauveria bassiana, on the other hand, revealed no differences in survival. Moreover, elimination of Wolbachia was beneficial for the parasitoid wasp, as eggs laid by uninfected females suffered significantly lower encapsulation rates. We discuss possible origins of these fitness costs and their implications for infection dynamics and the interactions between host species
Discontinuous molecular dynamics for rigid bodies: Applications
No full textEvent-driven molecular dynamics simulations are carried out on two rigid-body systems which differ in the symmetry of their molecular mass distributions. First, simulations of methane in which the molecules interact via discontinuous potentials are compared with simulations in which the molecules interact through standard continuous Lennard-Jones potentials. It is shown that under similar conditions of temperature and pressure, the rigid discontinuous molecular dynamics method reproduces the essential dynamical and structural features found in continuous-potential simulations at both gas and liquid densities. Moreover, the discontinuous molecular dynamics approach is demonstrated to be between 3 and 100 times more efficient than the standard molecular dynamics method depending on the specific conditions of the simulation. The rigid discontinuous molecular dynamics method is also applied to a discontinuous-potential model of a liquid composed of rigid benzene molecules, and equilibrium and dynamical properties are shown to be in qualitative agreement with more detailed continuous-potential models of benzene. The few qualitative differences in the angular dynamics of the two models are related to the relatively crude treatment of variations in the discontinuous repulsive interactions as one benzene molecule rotates by another. (c) 2007 American Institute of Physics.PT: J; CR: ALDER BJ, 1959, J CHEM PHYS, V31, P459 BELLEMANS A, 1980, MOL PHYS, V39, P781 CACELLI I, 2004, J AM CHEM SOC, V126, P14278 CHAPELA GA, 1984, MOL PHYS, V53, P139 CHAPELA GA, 1989, CHEM PHYS, V129, P201 DELAPENA LH, 2007, J CHEM PHYS, V126 DEMICHELE C, 2006, J PHYS CHEM B, V110, P8064 DING F, 2003, PROTEINS, V53, P220 DUANE S, 1987, PHYS LETT B, V195, P216 DULLWEBER A, 1997, J CHEM PHYS, V107, P5840 FALCONE DR, 1967, J PHYS CHEM-US, V71, P2754 MACKERELL AD, 1998, J PHYS CHEM B, V102, P3586 NGUYEN HD, 2006, J AM CHEM SOC, V128, P1890 PRESS WH, 1992, NUMERICLA RECIPES FO RAPAPORT DC, 1979, J CHEM PHYS, V71, P3299 RAPAPORT DC, 2004, ART MOL DYNAMICS SIM VANZON R, CONDMAT0612404 VANZON R, IN PRESS J COMPUT PH ZACHAROPOULOS N, 2005, J CHEM PHYS, V122 ZHOU YQ, 1999, J MOL BIOL, V293, P917; NR: 20; TC: 0; J9: J CHEM PHYS; PG: 12; GA: 138VLSource type: Electronic(1
Discontinuous molecular dynamics for semiflexible and rigid bodies
No full textA general framework for performing event-driven simulations of systems with semiflexible or rigid bodies interacting under impulsive forces is outlined. The method consists of specifying a means of computing the free evolution of constrained motion, evaluating the times at which interactions occur, and determining the consequences of interactions on subsequent motion. Algorithms for computing the times of interaction events and carrying out efficient event-driven simulations are discussed. The semiflexible case and the rigid case differ qualitatively in that the free motion of a rigid body can be computed analytically and need not be integrated numerically. (c) 2007 American Institute of Physics.PT: J; CR: ABRAMOWITZ M, 1965, HDB MATH FUNCTIONS F ALDER BJ, 1959, J CHEM PHYS, V31, P459 ALDER BJ, 1960, J CHEM PHYS, V33, P1439 ALLEN MP, 1987, COMPUTER SIMULATION ALLEN MP, 1989, COMPUT PHYS REP, V9, P301 ANDERSEN HC, 1983, J COMPUT PHYS, V52, P24 BARAFF D, 1989, COMPUT GRAPH, V23, P223 BARAFF D, 1992, THESIS CORNELL U BRENT RP, 1973, ALGORITHMS MINIMIZAT CARTER EA, 1989, CHEM PHYS LETT, V156, P472 CHAPELA GA, 1984, MOL PHYS, V53, P139 CHAPELA GA, 1989, CHEM PHYS, V129, P201 CICCOTTI G, 2004, J STAT PHYS, V115, P701 DELAPENA LH, UNPUB DELAPENA LH, 2005, J CHEM PHYS, V126 DEMICHELE C, 2006, J PHYS CHEM B, V110, P8064 DONEV A, 2005, J COMPUT PHYS, V202, P737 DONEV A, 2005, J COMPUT PHYS, V202, P765 ERPENBECK JJ, 1977, STAT MECH B FIXMAN M, 1974, P NATL ACAD SCI USA, V71, P3050 FRENKEL D, 2004, UNDERSTANDING MOL DY GALASSI M, 2005, GNU SCI LIB REFERENC GOLDSTEIN H, CLASSICAL MECH JACOBI CGJ, 1849, J CRELLE, V39, P293 KNOPP K, 1947, THEORY FUNCTIONS 2 LANDAU LD, 1976, MECHANICS LUBACHEVSKY BD, 1991, J COMPUT PHYS, V94, P255 MARIN M, 1993, J COMPUT PHYS, V109, P306 MARIN M, 1995, COMPUT PHYS COMMUN, V92, P214 MARSDEN JE, 2002, INTRO MECH SYMMETRY MASUTANI Y, 1994, P IEEE INT C ROB AUT, V2, P1066 MELCHIONNA S, 2000, PHYS REV E A, V61, P6165 MOSHIER SL, 1989, METHODS PROGRAMS MAT PRESS WH, 1992, NUMERICLA RECIPES FO RAMSHAW JD, 1986, PHYS LETT A, V116, P110 RAPAPORT DC, 1980, J COMPUT PHYS, V34, P184 RAPAPORT DC, 2004, ART MOL DYNAMICS SIM RUEB AS, 1834, THESIS UTRECHT NETHE RYCKAERT JP, 1977, J COMPUT PHYS, V23, P327 TUCKERMAN ME, 1999, EUROPHYS LETT, V45, P149 TUCKERMAN ME, 2001, J CHEM PHYS, V115, P1678 VANZON R, IN PRESS J COMPUT PH VANZON R, 2002, PHYS REV E 1, V65 WHITTAKER ET, 1937, TREATISE ANAL DYMANI; NR: 44; TC: 1; J9: J CHEM PHYS; PG: 13; GA: 138VLSource type: Electronic(1
A Western Australian kindred with Dutch cerebral amyloid angiopathy
No full textA family from the south of Western Australia is described with Dutch cerebral amyloid angiopathy (HCHWA-D). The proband died at age 60 from recurrent lobar haemorrhages in the brain, as did his sister and five other family members. The APP 693 mutation at position 22 of the Abetapeptide resulting in a glutamine for glutamic acid was identified in the proband and the affected sister. Pathologically lobar haemorrhages were found with cerebrovascular angiopathy; neuritic plaques were found but no neurofibrilary tangles. There was a leukoencephalopathy on MRI scanning. Dementia and cognitive decline has not been observed in this family. This is the first family reported outside of Europe and the Northern Hemisphere. The discovery highlights the importance of detecting this rare cause of fatal cerebral haemorrhage as it has implications for gene testing and general medical management.Peter K. Panegyres, John B. J. Kwok, Peter R. Schofield and Peter C. Blumberg
Is individual smoking behaviour influenced by area level ethnic density? A cross-sectional electronic health database study of inner south east London
No full textsmoking remains one of the greatest public health problems facing the UK today. It varies significantly by ethnic group. This study aimed to determine whether ethnic differences in smoking behaviour are related to neighbourhood level own-group ethnic density across south and east London. The association between ethnic density and individual smoking behaviour was assessed by multilevel logistic regression using the electronic health records of 688,397 GP registered patients. Restricted cubic splines were created to explore whether the effect of ethnic density on smoking behaviour was non-linear. Increasing own-group ethnic density was found to be associated with a significant reduction in the odds of being a current smoker in all ethnic groups, except for Caribbean women. The relationship between ethnic density and current smoking was found to be non-linear, with the strength of association varying significantly by gender and ethnic group. These novel findings point to a complex relationship between culture, neighbourhood level experience of adversity or social support and smoking behaviour, and will allow us to target smoking cessation services differentially to individuals/groups living in relative ethnic isolation, who do not benefit from the potential cultural/social factors associated with reduced tobacco consumption.This study was funded by a grant from The Curriers Company.The project was supported by a Curriers' Company Millennium Healthcare Bursary
Ad triangulum. The cathedral of Milan and its dome. From Stornaloco to Bramante, Leonardo and Giovanni Antonio Amadeo
No full textThe construction of the dome of Milan Cathedral represents one of the most fascinating and complex episodes in the history of Italian architecture of the fifteenth century. This is an exemplary case, for the specificity and exceptionality of the Fabbrica del Duomo and for the involvement of some of the most authoritative protagonists of the time - Bramante, Francesco di Giorgio Martini, Luca Fancelli and Leonardo da Vinci - invited by Giangaleazzo and Ludovico Maria Sforza to propose an innovative structural, constructive and formal solution. The desire of the ducal family to assert its image through this enterprise is the backdrop to the succession of builders, workers and ambitious projects committed to giving the building the right crowning glory. The complex story is traced here starting from the recognition of the importance of the intervention of the mathematician from Piacenza Gabriele Stornaloco, creator in 1391 of a geometric scheme to establish the dimensions of the elevation, to be considered the "Ariadne's thread" for the construction of the whole cathedral. Deepening the heated discussion on the adoption of different construction techniques - Lombard, Tuscan and transalpine - the numerous projects proposed to solve the problem of the dome, which pushes the Sforza and the Fabbrica to make use of prestigious consultancy, are then analyzed, also involving Leonardo da Vinci, author of a lost wooden model. Finally we come to the winning project of two Lombards, Giovanni Antonio Amedeo and Giangiacomo Dolcebuono who, between 1490 and 1500, built the dome up to the base of the lantern, using practices rooted in Lombard architectural culture, leaving out only the largest spire that will be built in 1769 as evidence of the complexity of a construction site that lasted over 400 years, making Milan Cathedral one of the most original architecture in Europe
Discussion
No full textHenry Louis, Van der Woude A. M., Sogner Solvi, Laslett Peter, Hollingsworth T.H., Deprez P., Kintz Jean-Pierre, Kovacsics Jozsef, Hayami Akira, Dányi Dezsö, Livi-Bacci Massimo, Sonnino Eugenio, Nadal Jordi, Hélin Etienne, Poussou Jean-Pierre, Corsini Carlo A., Charbonneau Hubert, Marcilio Maria-Luisa, Fedele S., Dupâquier Jacques, Schofield R.S., Andorka Rudolf, Legare Jacques, Blayo Yves, Zanni R., Desama Claude, Parenti G. Discussion. In: Annales de démographie historique, 1972. Techniques et méthodes. Actes du colloque de Florence, 1er-3 octobre 1971. pp. 365-383
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