1,636 research outputs found
Shared versus distinct genetic contributions of mental wellbeing with depression and anxiety symptoms in healthy twins
No full textAvailable online 9 July 2016Abstract not availableKylie M. Routledge, Karen L.O. Burton, Leanne M. Williams, Anthony Harris, Peter R. Schofield, C. Richard Clark, Justine M.Gat
Sex differences in the shared genetics of dimensions of self-reported depression and anxiety
No full textAbstract not available.Karen L.O. Burton, Leanne M. Williams, C. Richard Clark, Anthony Harris, Peter R. Schofield, Justine M. Gat
Resting energy expenditure prediction equations given in their original unit (kcal/day, except Schofield (MJ/day)).
No full text<p>Resting energy expenditure prediction equations given in their original unit (kcal/day, except Schofield (MJ/day)).</p
Compound heterozygosity and nonsense mutations in the alpha(1)-subunit of the inhibitory glycine receptor in hyperekplexia
No full textKerr M, Snell RG, Schofield PR, Owen M
Discussion
No full textSchofield R.S., Coale A.-J., Henry Louis, Hollingsworth T.H., Desama Claude, van de Walle Etienne, Livi-Bacci Massimo, Dupâquier Jacques, Deprez P., Poussou Jean-Pierre, Andorka Rudolf, Laslett Peter, Marcilio Maria-Luisa, Nadal Jordi, Dányi Dezsö, Hélin Etienne, Cipolla Carlo- M. Discussion. In: Annales de démographie historique, 1972. Techniques et méthodes. Actes du colloque de Florence, 1er-3 octobre 1971. pp. 225-244
Discontinuous molecular dynamics for semiflexible and rigid bodies
No full textA general framework for performing event-driven simulations of systems with semiflexible or rigid bodies interacting under impulsive forces is outlined. The method consists of specifying a means of computing the free evolution of constrained motion, evaluating the times at which interactions occur, and determining the consequences of interactions on subsequent motion. Algorithms for computing the times of interaction events and carrying out efficient event-driven simulations are discussed. The semiflexible case and the rigid case differ qualitatively in that the free motion of a rigid body can be computed analytically and need not be integrated numerically. (c) 2007 American Institute of Physics.PT: J; CR: ABRAMOWITZ M, 1965, HDB MATH FUNCTIONS F ALDER BJ, 1959, J CHEM PHYS, V31, P459 ALDER BJ, 1960, J CHEM PHYS, V33, P1439 ALLEN MP, 1987, COMPUTER SIMULATION ALLEN MP, 1989, COMPUT PHYS REP, V9, P301 ANDERSEN HC, 1983, J COMPUT PHYS, V52, P24 BARAFF D, 1989, COMPUT GRAPH, V23, P223 BARAFF D, 1992, THESIS CORNELL U BRENT RP, 1973, ALGORITHMS MINIMIZAT CARTER EA, 1989, CHEM PHYS LETT, V156, P472 CHAPELA GA, 1984, MOL PHYS, V53, P139 CHAPELA GA, 1989, CHEM PHYS, V129, P201 CICCOTTI G, 2004, J STAT PHYS, V115, P701 DELAPENA LH, UNPUB DELAPENA LH, 2005, J CHEM PHYS, V126 DEMICHELE C, 2006, J PHYS CHEM B, V110, P8064 DONEV A, 2005, J COMPUT PHYS, V202, P737 DONEV A, 2005, J COMPUT PHYS, V202, P765 ERPENBECK JJ, 1977, STAT MECH B FIXMAN M, 1974, P NATL ACAD SCI USA, V71, P3050 FRENKEL D, 2004, UNDERSTANDING MOL DY GALASSI M, 2005, GNU SCI LIB REFERENC GOLDSTEIN H, CLASSICAL MECH JACOBI CGJ, 1849, J CRELLE, V39, P293 KNOPP K, 1947, THEORY FUNCTIONS 2 LANDAU LD, 1976, MECHANICS LUBACHEVSKY BD, 1991, J COMPUT PHYS, V94, P255 MARIN M, 1993, J COMPUT PHYS, V109, P306 MARIN M, 1995, COMPUT PHYS COMMUN, V92, P214 MARSDEN JE, 2002, INTRO MECH SYMMETRY MASUTANI Y, 1994, P IEEE INT C ROB AUT, V2, P1066 MELCHIONNA S, 2000, PHYS REV E A, V61, P6165 MOSHIER SL, 1989, METHODS PROGRAMS MAT PRESS WH, 1992, NUMERICLA RECIPES FO RAMSHAW JD, 1986, PHYS LETT A, V116, P110 RAPAPORT DC, 1980, J COMPUT PHYS, V34, P184 RAPAPORT DC, 2004, ART MOL DYNAMICS SIM RUEB AS, 1834, THESIS UTRECHT NETHE RYCKAERT JP, 1977, J COMPUT PHYS, V23, P327 TUCKERMAN ME, 1999, EUROPHYS LETT, V45, P149 TUCKERMAN ME, 2001, J CHEM PHYS, V115, P1678 VANZON R, IN PRESS J COMPUT PH VANZON R, 2002, PHYS REV E 1, V65 WHITTAKER ET, 1937, TREATISE ANAL DYMANI; NR: 44; TC: 1; J9: J CHEM PHYS; PG: 13; GA: 138VLSource type: Electronic(1
Discussion
No full textSchofield R.S., Dányi Dezsö, Andorka Rudolf, Hélin Etienne, Deprez P., Kintz Jean-Pierre, Hollingsworth T.H., Corsini Carlo A., Cipolla Carlo- M., Henry Louis, Fedele S., Poussou Jean-Pierre, Bardet Jean-Pierre, Sonnino Eugenio, Hayami Akira, Kovacsics Jozsef, Laslett Peter, Dupâquier Jacques, Livi-Bacci Massimo, Charbonneau Hubert, Nadal Jordi. Discussion. In: Annales de démographie historique, 1972. Techniques et méthodes. Actes du colloque de Florence, 1er-3 octobre 1971. pp. 127-146
Frontotemporal dementia-amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1-q12.2: genetic, clinical and neuropathological analysis
No full textNumerous families exhibiting both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have been described, and although many of these have been shown to harbour a repeat expansion in C9ORF72, several C9ORF72-negative FTD-ALS families remain. We performed neuropathological and genetic analysis of a large European Australian kindred (Aus-12) with autosomal dominant inheritance of dementia and/or ALS. Affected Aus-12 members developed either ALS or dementia; some of those with dementia also had ALS and/or extrapyramidal features. Neuropathology was most consistent with frontotemporal lobar degeneration with type B TDP pathology, but with additional phosphorylated tau pathology consistent with corticobasal degeneration. Aus-12 DNA samples were negative for mutations in all known dementia and ALS genes, including C9ORF72 and FUS. Genome-wide linkage analysis provided highly suggestive evidence (maximum multipoint LOD score of 2.9) of a locus on chromosome 16p12.1–16q12.2. Affected individuals shared a chromosome 16 haplotype flanked by D16S3103 and D16S489, spanning 37.9 Mb, with a smaller suggestive disease haplotype spanning 24.4 Mb defined by recombination in an elderly unaffected individual. Importantly, this smaller region does not overlap with FUS. Whole-exome sequencing identified four variants present in the maximal critical region that segregate with disease. Linkage analysis incorporating these variants generated a maximum multipoint LOD score of 3.0. These results support the identification of a locus on chromosome 16p12.1–16q12.2 responsible for an unusual cluster of neurodegenerative phenotypes. This region overlaps with a separate locus on 16q12.1–q12.2 reported in an independent ALS family, indicating that this region may harbour a second major locus for FTD-ALS.Carol Dobson-Stone, Agnes A. Luty, Elizabeth M. Thompson, Peter Blumbergs, William S. Brooks, Cathy L. Short, Colin D. Field, Peter K. Panegyres, Jane Hecker, Jennifer A. Solski, Ian P. Blair, Janice M. Fullerton, Glenda M. Halliday, Peter R. Schofield, John B. J. Kwo
Bunker Hauntology
No full textAbstract:
“This architecture floats on the surface of an earth that has lost its materiality” (Virilio, 1967)
In Bunker Archaeology (1967), a seminal book by Paul Virilio, the renowned cultural theorist presents a typology of modern war ruins through photography and reflective text. He represented the remains of Hitler’s Atlantic Wall as important European cultural heritage, imperative (if oft-overlooked and neglected) reminders of the horrors of global war. Bunkers, batteries and pill boxes litter Europe’s western beaches today. Despite their imposing physical presence along the coastline, Virilio describes his primary experience of them as one characterized by absence.
In Views from Sunk Island (2022), an essay film and photographic series by the author of this paper, an echo of these remains is explored on Britain’s eastern shore. The bunkers here are threatened by rising sea levels and rapid coastal erosion. Even during the months of production, things were shifting profoundly, with fortresses crashing onto beaches and batteries disappearing beneath the waves. The UK has no equivalent muse on the value of these endangered objects as cultural heritage. This presentation explores the haunting significance of these disappearances, and the role photography and the digital archive can play, in preserving a trace of these bunkers, both as part of Britain’s cultural memory and a gesture towards revealing and re-evaluating some of the darker parts of our own heritage.
The paper also explores the role of the author’s own practice research – returning, revisiting, and re-photographing these sites - in interrogating the selective memory of photography itself, and how this might be counteracted through iterative practices
Grand Army of the Republic P.01
No full textReading from left to right: Peter Huddleston, T. W. Brookbank, C. N. Schofield, I. A. Smith, a Tennessee Veteran, Russell D. Woodruff, Elias Price, Joanna Melton, C. W. A. Schnell, Wm. J. Johnson, L. L. Hudson, W. M. Goodsell, Ira Stormes, N. D. Corser
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