351 research outputs found
Gertrude & Bert Heger
No full textMarried couple Berthold "Bert", born 1904, and Gertrude, born June 16, 1909, Heger from Vienna, Austria, provide Holocaust survivor testimony. After the Anschluss, Mr. and Mrs. Heger survived Kristallnacht in Vienna though Mr. Heger was arrested, and they fortunately managed to emigrate to the United States by 1939. Interviewers: Rabbi Samuel Kenner and Natalie Lederman. Camera: Peter Drougas. Note Taker: Zelda Kaplan. Taped at Cablevision, Peabody, Massachusetts
Genome wide mapping of the MBF-1 binding sites during embryogenesis of the sea urchin reveals it is a chromatin organizer.
No full textThe Zinc-finger MBF1 factor is a transcription activator involved in the expression of the early histone genes during development of the sea urchin embryo (1). The DNA-binding domain of MBF1 shares high sequence similarity with that of the CTCF chromatin organizer but, unexpectedly, extensive in silico analysis failed to identify the sea urchin CTCF ortholog (2, 3). This led us to speculate that MBF1 could have co-opted the function of CTCF during evolution of the echinoderms. To support this hypothesis, we performed the genome-wide MBF1-binding sites mapping in the P. lividus genome, by chromatin immunoprecipitation coupled to next generation sequencing (ChIP-Seq). We observed that MBF1 binding motifs are spread across the genome, with a CCCTC core sequence showing perfect conservation with the mammalian CTCF binding element. In particular, MBF1 binds to the promoter regions of hundreds of target genes. Among others, we confirmed the specific interaction with the promoters of histone and Hox genes, and observed the full evolutionary conservation of these binding sites in P. lividus and S. purpuratus species.
Next, to appraise globally the functional meaning of binding events we analyzed the MBF1 occupancy in chromatin samples derived from embryos exposed to compounds, such as Lithium and Zinc, that impair axial pattering. Comparison with controls revealed differential MBF1 recruitment on selected genes reflecting differentially regulated mechanisms in treated embryos. The molecular pathways impacted by Li and Zn include cell signaling, gene transcription, DNA repair, and chromatin condensation.
Collectively, our observations highlight the DNA binding potency of MBF1, strongly suggesting that it could act both as a transcription factor of its target genes and a general chromatin organizer.
1. Cavalieri, V et al. (2009) Nucleic Acid Res, 37,7407-15.
2. Heger , P et al. (2012) PNAS, 109, 17507-12.
3. Cavalieri, V et al. (2013) Plos Genetics, 9, e1003847
Women in the Bible, Qumran, and early Rabbinic literature : their status and roles / by Peter Heger
No full textWomen in the Bible, Qumran, and early Rabbinic literature : their status and roles
No full textby Peter Hege
Supplements for "Solvent Accessibility Promotes Rotamer Errors During Protein Modelling with Major Side-Chain Prediction Programs"
No full textSupplements for "Solvent Accessibility Promotes Rotamer Errors During Protein Modelling with Major Side-Chain Prediction Programs"
This supplement includes the following files:
Main.R --- Script in R language to process files (in "pdb.zip") and produce the datasets ("Datasets.zip")
functions.zip --- supplementary functions to the R script (in "Main.R")
pdb.zip --- PDB files include filtered structures processed by three programs
Datasets.zip --- Three versions of dataset produced in R language (by "Main.R"). The first two versions may contain unfiltered structures
The article featuring this dataset is submitted to:
Journal: Journal of Chemical Information and Modeling
Manuscript ID: ci-2023-00134a
Title: "Solvent Accessibility Promotes Rotamer Errors During Protein Modelling with Major Side-Chain Prediction Programs"
Author(s): Hameduh, Tareq; Mokry, Michal ; Miller, Andrew ; Heger, Zbynek; Haddad, YazanThis work was supported by Internal Grant Agency of Mendel University in Brno [AF-IGA2022-IP-081]; Czech Health Research Council [NU21J-08-00043]; Czech Science Foundation [22-14568S]; Czech Ministry of Education, Youth and Sports OPVVV Project FIT (Pharmacology, Immunotherapy, nanoToxicology) [CZ.02.1.01/0.0/0.0/15_003/0000495] awarded to ADM with financial support from the European Regional Development Fund
Hans Peter Kunert, Aspekt, Aktionsart, Tempus - Eine Untersuchung zur Wiedergabe russischer Verbalkategorien im Französischen
No full text
Periodicities in the high-mass X-ray binary system RXJ0146.9+6121/LSI+61 235
No full textThe high-mass X-ray binary RX J0146.9+6121, with optical counterpart LS I+61°235 (V831 Cas), is an intriguing system on the outskirts of the open cluster NGC 663. It contains the slowest Be type X-ray pulsar known with a pulse period of around 1400 s and, primarily from the study of variation in the emission line profile of Hα, it is known to have a Be decretion disc with a one-armed density wave period of approximately 1240 d. Here we present the results of an extensive photometric campaign, supplemented with optical spectroscopy, aimed at measuring short time-scale periodicities. We find three significant periodicities in the photometric data at, in order of statistical significance, 0.34, 0.67 and 0.10 d. We give arguments to support the interpretation that the 0.34 and 0.10 d periods could be due to stellar oscillations of the B-type primary star and that the 0.67 d period is the spin period of the Be star with a spin axis inclination of 23+10−8 degrees. We measured a systemic velocity of −37.0 ± 4.3 km s−1 confirming that LS I+61°235 has a high probability of membership in the young cluster NGC 663 from which the system's age can be estimated as 20–25 Myr. From archival RXTE All Sky Monitor (ASM) data we further find ‘super’ X-ray outbursts roughly every 450 d. If these super outbursts are caused by the alignment of the compact star with the one-armed decretion disc enhancement, then the orbital period is approximately 330 d
Correction to “Trace Water in Lead Iodide Affecting Perovskite Crystal Nucleation Limits the Performance of Perovskite Solar Cells”
No full textOn Page 1, the authors’ affiliation error for the corresponding author, the text “R. Guo, T. Xiao, S. Liang, J. E. Heger, T. Guan, X. Jiang, K. Sun, L. K. Reb, M. A. Reus” was incorrect. This should have read:“R. Guo, T. Xiao, S. Liang, J. E. Heger, T. Guan, X. Jiang, K. Sun, L. K. Reb,M. A. Reus, P. Müller-Buschbaum.”On Page 3, word error in Figure 1 caption, line 6. The text:“Lead diffuses slowly in the lead part and reacts with the melted lead.” was incorrect. This should have read: “Iodine diffuses slowly in the lead part and reacts with the melted lead.”On Page 8, indicator connection error with SI information, in the OPTP Experimental Setup of the “Experimental Section,” the text “The pump fluence was adjusted with a neutral density filter wheel to obtain photoexcitation pulse fluence of 25, 20, 12, 6, and 3 µJ cm−2 for respective decay traces shown in Figure S15 (Supporting Information).” was incorrect. This should have read: “The pump fluence was adjusted with a neutral density filter wheel to obtain photoexcitation pulse fluence of 25, 20, 12, 6, and 3 µJ cm−2 for respective decay traces shown in Figure S20 (Supporting Information).”On Page 9, indicator connection error with SI information. In the “Drift-Diffusion Simulation” of the “Experimental Section,” the text “All detailed parameters for simulation are shown in Tables S4 and S5 (Supporting Information).” was incorrect. This should have read: “All detailed parameters for simulation are shown in Tables S6–S8 (Supporting Information).”We apologize for these errors
Polarimetry of the transient relativistic jet of GRB 110328/Swift J164449.3+573451
No full textWe present deep infrared (Ks-band) imaging polarimetry and radio (1.4- and 4.8-GHz) polarimetry of the enigmatic transient Swift J164449.3+573451. This source appears to be a short-lived jet phenomenon in a galaxy at redshift z= 0.354, activated by a sudden mass accretion on to the central massive black hole, possibly caused by the tidal disruption of a star. We aim to find evidence for this scenario through linear polarimetry, as linear polarization is a sensitive probe of jet physics, source geometry and the various mechanisms giving rise to the observed radiation. We find a formal Ks-band polarization measurement of Plin= 7.4 ± 3.5 per cent (including systematic errors). Our radio observations show continuing brightening of the source, which allows sensitive searches for linear polarization as a function of time. We find no evidence of linear polarization at radio wavelengths of 1.4 and 4.8 GHz at any epoch, with the most sensitive 3σ limits as deep as 2.1 per cent. These upper limits are in agreement with expectations from scenarios in which the radio emission is produced by the interaction of a relativistic jet with a dense circumsource medium. We further demonstrate how polarization properties can be used to derive properties of the jet in Swift J164449.3+573451, exploiting the similarities between this source and the afterglows of gamma-ray bursts
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