55 research outputs found
Impact of mesenchymal stem cells on islets revascularization after transplantation into the extracellular matrix
No full textPancreatic transplantation is the only possible treatment to induce independence from exogenous insulin administration in type 1 diabetes mellitus. However, the shortage of donor organs remains the main limitation of pancreas transplantations. The goal of the research is the preparation of a bioartificial organ based on cell therapy. Parts of the extracellular matrix obtained by decellularization of the pancreas are used for its preparation. The protein scaffolds prepared in this way are then repopulated by different cell types again. The extracellular matrix provides structural support to cells, mediates signaling for differentiation, proliferation or migration. Mesenchymal stromal cells are used in clinical therapy, have a positive effect on tissue regeneration processes, modulating the function of the extracellular matrix, suppress inflammation and promote angiogenesis. After pancreas decellularization, we repopulated the extracellular matrix with islets, mesenchymal cells and endothelial cells. Then, the pancreas was transplanted subcutaneously into syngeneic diabetic rats to observe islet revascularization. Based on sections of explanted scaffolds, we found out that revascularization of the islets was higher without the endothelial cells in the transplanted extracellular matrix. Key words:..
Condensing steam turbine
No full textThe master´s thesis concentrates on a project of condensing steam turbine for existing heating plant with back pressure turbine. The master´s thesis subject consists in the thermodynamic calculation of regulating stage and turbine stages. Design documentation is worked up according to the calculated record. From calculated power of turbine is worked a basic project of gearbox and disposal arrangement system
Single stage steam turbine
No full textThe thesis deals with design of single stage steam turbine. Applicable alternatives with appraisal and variant solving were developed on the basis of overheated steam parameters. Main thesis output is design of the most appropriate variant with real turbine’s dimension and the most fitted applicability and the best effectiveness
Transplantace inzulín produkující tkáně: hlavní principy a pro-blematika mTOR inhibitorů
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The IKEM Pancreas and Islet Transplant Program as Part of Healthcare for Type 1 Diabetes Patients: Retrospective Analysis of Outcome from 1983 to 2010
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Existence of cryogenic magnetic entropy change in Gd based nanoparticles
No full textMagnetic nanoparticles with average diameter of 5–7 nm were prepared by nanocasting method inside of the pores of periodic silica matrix of SBA15 type. The uniform size of the pores limited the particles' growth what resulted in formation of nanocomposite consisting of monodisperse nanoparticles of Gd₂O₃ embedded in amorphous silica matrix. Magnetic properties of the material were examined in magnetic fields up to 5 T and in temperature range 2–52 K. The magnetic entropy change of 29 J/kg K was observed at 2 K for field variation 5 T in the investigated nanocomposite what suggests this material could be feasible for cryomagnetic refrigeration applications.This work was supported by the Slovak Research and
Development Agency under the contracts APVV-0073-14
and APVV-520-15 and by the VEGA projects (No.
1/0377/16, No. 1/0745/17). Authors would like to thank
V. Girman for realization of TEM experiments. Author
A.B. would like to thank Visegrad Fund under contract
No. 51501516 for financial support
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