9,518 research outputs found
sj-docx-1-cho-10.1177_18632521231156434 – Supplemental material for Return to sport after forearm fractures in children: A scoping review and survey
No full textSupplemental material, sj-docx-1-cho-10.1177_18632521231156434 for Return to sport after forearm fractures in children: A scoping review and survey by Ameya Bhanushali, Rebecca Bright, Louis Xu, Peter Cundy and Nicole Williams in Journal of Children's Orthopaedics</p
Sequentially testing polynomial model hypotheses using power transforms of regressors
No full textWe provide a methodology for testing a polynomial model hypothesis by generalizing the approach and results of Baek, Cho, and Phillips (Journal of Econometrics, 2015, 187, 376–384; BCP), which test for neglected nonlinearity using power transforms of regressors against arbitrary nonlinearity. We use the BCP quasi-likelihood ratio test and deal with the new multifold identification problem that arises under the null of the polynomial model. The approach leads to convenient asymptotic theory for inference, has omnibus power against general nonlinear alternatives, and allows estimation of an unknown polynomial degree in a model by way of sequential testing, a technique that is useful in the application of sieve approximations. Simulations show good performance in the sequential test procedure in both identifying and estimating unknown polynomial order. The approach, which can be used empirically to test for misspecification, is applied to a Mincer (Journal of Political Economy, 1958, 66, 281–302; Schooling, Experience and Earnings, Columbia University Press, 1974) equation using data from Card (in Christofides, Grant, and Swidinsky (Eds.), Aspects of Labour Market Behaviour: Essays in Honour of John Vanderkamp, University of Toronto Press, 1995, 201-222) and Bierens and Ginther (Empirical Economics, 2001, 26, 307–324). The results confirm that the standard Mincer log earnings equation is readily shown to be misspecified. The applications consider different datasets and examine the impact of nonlinear effects of experience and schooling on earnings, allowing for flexibility in the respective polynomial representations
Erratum: 3D bioprinted in vitro secondary hyperoxaluria model by mimicking intestinal-oxalatemalabsorption-related kidney stone disease (Applied Physics Reviews (2022) 9 (041408) DOI: 10.1063/5.0087345)
No full text© 2023 Author(s).This article was originally published online on 21 November 2022 with an incorrect affiliation identifier for author Dong-Woo Cho. It is correct as it appears above. All online versions of this article were corrected on 23 November 2022. AIP Publishing apologizes for this error.11Nsciescopu
Unimodality of Betti numbers for Hamiltonian circle actions with index-increasing moment Maps
No full textThe unimodality conjecture posed by Tolman in [L. Jeffrey, T. Holm, Y. Karshon, E. Lerman and E. Meinrenken, Moment maps in various geometries, http://www.birs.ca/workshops/2005/05w5072/report05w5072.pdf] states that if (M,ω) is a 2n-dimensional smooth compact symplectic manifold equipped with a Hamiltonian circle action with only isolated fixed points, then the sequence of Betti numbers {b0(M),b2(M),...,b2n(M)} is unimodal, i.e. bi(M) ≤ bi+2(M) for every i < n. Recently, the author and Kim [Y. Cho and M. Kim, Unimodality of the Betti numbers for Hamiltonian circle action with isolated fixed points, Math. Res. Lett. 21(4) (2014) 691-696] proved that the unimodality holds in eight-dimensional case by using equivariant cohomology theory. In this paper, we generalize the idea in [Y. Cho and M. Kim, Unimodality of the Betti numbers for Hamiltonian circle action with isolated fixed points, Math. Res. Lett. 21(4) (2014) 691-696] to an arbitrary dimensional case. We prove the conjecture in arbitrary dimension under the assumption that the moment map H : M → R is index-increasing, which means that ind(p) < ind(q) implies H(p) < H(q) for every pair of critical points p and q of H, where ind(p) is the Morse index of p with respect to H. © World Scientific Publishing Company1111sciescopu
Systems biology for reverse aging
No full textCellular senescence is an irreversible and permanent cell cycle arrest in response to internal and external stresses. Its unresponsiveness to growth factor signals distinguishes it from a potentially reversible state, quiescence. Cellular senescence can inhibit tumor development by blocking proliferation of damaged cells, but as senescent cells become accumulated in a tissue, they can contribute to the promotion of agerelated diseases such as cancer by secreting inflammatory cytokines [1]. © 2021 Cho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
The antihypertensive effects of the Jamaican Cho-Cho (Sechium edule)
No full textThe experiments reported in this study constitute a preliminary investigation into the possible hypotensive effect of the Jamaican Cho-Cho (Sechium edule). Experiments were conducted in a random and blind fashion on two sub species of Sechium edule. Both the pulp and the peel were examined for hypotensive activity. Water-soluble extracts were prepared from these components of the fruit and injected into anaesthetised rats. Various cardiovascular parameters were measured including heart rate, mean arterial pressure (MAP) and several ECG intervals. We report that all extracts tested produced a fall in blood pressure with little change in ECG intervals. Extract B produced the least change in heart rate with a fall in MAP of approximately 23 mmHg. Changes in heart rate with all extracts appeared to be minimal as an ED25 value could only be determined for extract A, and ED10 values could not be evaluated for extracts C and D. The mechanism(s) by which these extracts produce their hypotensive effects could not be determined in these preliminary experiments. However, it appears not to involve direct effects on cardiac tissue. This conclusion is based on the finding that it took a minimum of 10 to 15 seconds for the hypotensive action to manifest post bolus. Future experiments will be aimed at delineating the mechanism(s) involved in decreasing MAP.Peer reviewedfinal article publishe
Nota su Eschilo, Cho. 65
No full textThe author defends the reading ἄκραντος in the sense of “unfinished” in Aesch. Cho. 65
1‑Formyl-7-hydroxy-6,7-dihydro‑5<i>H</i>‑pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids
No full textPyrrolizidine
alkaloids (PAs) are phytochemicals present in more
than 6000 plant species worldwide; about half of the PAs are hepatotoxic,
genotoxic, and carcinogenic. Because of their wide exposure and carcinogenicity,
the International Programme on Chemical Safety (IPCS) concluded that
PAs are a threat to human health and safety. We recently determined
that PA-induced liver tumor initiation is mediated by a set of four
(±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-DNA adducts and proposed that these DHP-DNA adducts
are biomarkers of PA exposure and liver tumor initiation. To validate
the generality of this metabolic activation pathway and DHP-DNA adducts
as biomarkers, it is significant to identify reactive metabolites
associated with this metabolic activation pathway. Segall et al. (Segall et al. (1984) Drug Metab. Dispos. 12, 68−71) previously reported that 1-formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP) is generated from the metabolism
of senecionine by mouse liver microsomes. In the present study, we
examined the metabolism of seven hepatocarcinogenic PAs (senecionine,
intermedine, retrorsine, riddelliine, DHR, heliotrine, and senkirkine)
and one noncarcinogenic PA (platyphylline) by human, rat, and mouse
liver microsomes. 1-CHO-DHP was identified as a common metabolite
from the metabolism of these hepatotoxic PAs, but not from platyphylline.
Incubation of 1-CHO-DHP with HepG2 and A549 cells produced the same
set of DHP-DNA adducts, which were identified by both LC/MS MRM mode
and selected ion monitoring analyses through comparison to synthetic
standards. In the incubation medium of 1-CHO-DHP treated HepG2 cells,
both DHP and 7-cysteine-DHP were formed, which were capable of binding
to cellular DNA to produce DHP-DNA adducts. These results suggest
that 1-CHO-DHP is a proximate DNA metabolite of genotoxic and carcinogenic
PAs
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