196,000 research outputs found

    In vitro percutaneous penetration of polycyclic aromatic hydrocarbons from sunscreen creams

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    Background: Dermal exposure to Polycyclic Aromatic Hydrocarbons (PAHs) affects many outdoor workers such as asphalt workers. Usually the use of sunscreen creams is suggested to protect them from UV radiation. However sunscreen could prevent or facilitate dermal absorption of industrial chemicals. Objectives: The aim of the study was to assess percutaneous penetration of anthracene using 2 different sunscreen creams as vehicle. Methods: In vitro permeation experiments were carried out using standardized in vitro methods with static diffusion cells. Excised human skin prepared to approximately 350 mm thickness was fixed on the diffusion cells. The receiving phase was a saline solution with 6% PEG 20. The 2 sunscreen creams (one lipophilic and one hydrophilic) were applied uniformly (2mg/cm2) on the skin mounted on the diffusion cell. After 20 minutes, a solution of anthracene and artificial sweat was added. Analysis of anthracene in the receptor samples was carried out by beta counter analyzer (Packard). Results: Results did not show a percutaneous penetration of anthracene from sunscreen creams while in previous studies in vitro percutaneous penetration of anthracene was demonstrated using the same methodology. Discussion and Conclusion: The use of sunscreen creams among outdoor workers, would not seem to enhance percutaneous penetration of PAHs. On the contrary it seems to be able to reduce dermal absorption of anthracene in the workplace

    Increased plasma concentrations of antiprothrombin antibodies in women with recurrent spontaneous abortion

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    Background: Antiphospholipid antibodies are associated with recurrent fetal loss, but the clinical relevance of antiprothrombin (aPT) antibodies remains controversial. This study was designed to evaluate the relationship of plasma concentrations of aPT antibodies (IgG, IgM, and IgA isotypes) and recurrent spontaneous abortion (RSA) not associated with antiphospholipid-antibody syndrome. Methods: In this retrospective case-control study, we measured plasma aPT antibodies in 100 pregnant women at 8-12 weeks of gestation who had histories of recurrent abortion not associated with antiphospholipid-antibody syndrome. The controls were 200 healthy gestational-age-matched women with uncomplicated gestations. Results: The mean (SD) plasma aPT concentrations were significantly (P < 0.001) higher in women with histories of recurrent abortion than in healthy controls [7.97 (0.79) and 2.08 (0.07) kU/L]. Similarly, the concentrations of IgM aPT were significantly (P < 0.001) higher in patients than in controls [5.73 (0.85) and 1.83 (0.05) kU/L]. No differences were found for IgA aPT (P 0.358). Conclusions: High concentrations of aPT antibodies (IgG and IgM isotypes) are associated with pregnancy loss in women with RSA. We suggest that the antibodies may have a relevant role in the etiology and pathogenesis of the condition. (c) 2007 American Association for Clinical Chemistr

    Serum-soluble mesothelin family proteins (SMRP) assay in asbestos-exposed workers within a health surveillance program [Determinazione della mesotelina serica in lavoratori ex esposti ad amianto sottoposti a sorveglianza sanitaria]

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    Pleural plaques, pulmonary asbestosis, malignant pleural mesothelioma (MPM) and lung carcinoma are the most frequent diseases in asbestos exposed workers. In Italy asbestos enployment was banned for about 15 years, however, the asbestos-related diseases are still a great clinical interest because of long latency of mesothelioma and lung cancer. Until now, despite of the widely exposed population, diagnostic strategy is exclusively based on radiological examinations. Early biomarker assay is therefore an integrative approach tending to substitute for imaging. The diagnostic usefulness and prognostic value of Serum-soluble mesothelin family proteins (SMRPs) test in MPM have been demonstrated by several studies. Moreover SRMP levels higher than cut-off seem to be an independent factor for decreased survival and a good predictor of mortality. In the present study SMRP levels have been determined both in a popul

    Dr. Duane M. Jackson, Morehouse College, July 2011

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    This video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer

    "Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.

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    "Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states. By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement. To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Dr. Glendon Swarthout

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    Hosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
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