1,720,953 research outputs found
Étude préliminaire de l'innocuité et de l'efficacité du vaccin AUSKIPRA BK® contre la maladie d'Aujeszky chez des chiens de chasse du département de l'Aube
No full textAujeszky's disease or pseudorabies (PrV) is a viral disease caused by the Suid Herpesvirus type 1. It infects Suidae which are the reservoir hosts, and dogs in which it leads to death within a few hours to a few days with demented pruritus as a characteristic clinical sign. France is currently free of pseudorabies in pig farms but the virus still remains in wild boars. Since 2014 mortality of dogs due to pseudorabies has been increasing during the wild boar hunting season. Without treatment, hunting dog owners inquire for a vaccine. The purpose of this study was to assess the safety and efficacy of the AUSKIPRA® BK vaccine, which is available in France for hunting dogs outside the scope of the marketing authorization (AMM) with a temporary authorization (ATU) and has been conducted in the Aube department. By dosing anti-gB antibodies (Ab) in 328 wild boars, the pseudorabies seroprevalence was estimated at 22.6% in wild boars in the department during the year 2021-2022. A cohort study was conducted on 149 hunting dogs that were vaccinated with two primary injections and a booster dose at 6 months. Adverse effects were recorded by owners or veterinarians: 45.6 % of the dogs showed no clinical signs following the vaccine injections, 34.4% had at least one episode of local clinical signs at the injection site with mostly swelling (22.2 %), warmth (13.3 %) and pain (5.6 %) ; 31.1% had at least one episode of signs of change of general condition with mostly prostration (18.9 %) and change in appetite (12.2 %) in the days following the injection; 11.1 % had at least one episode of severe signs with vomiting (4.4 %) and breathing difficulties (3.3 %) with resolution of the majority of the clinical signs in the hours or days following vaccination. Four blood samples were taken from each dog in the study to assess the level of anti-gB Ab with competitive ELISA. The vaccine resulted in seroconversion for anti-gB Ab of all vaccinated dogs following the two primary injections and 97.7 % of dogs were seropositive 6 months after primary vaccination. Seroneutralization was performed in 31 dogs in the study showing seroneutralizing Ab for 80.6% of dogs following the two primary injections, with a decrease to 25.8 % in the 6 months, before the booster dose. The dosing of anti-gE Ab by competitive ELISA allowed the detection of one dog, out of 140, having encountered and survived the virus. This dog had anti-PrV Ab at the time of the contact with the virus and seroneutralized Ab after contact. One vaccinated dog among the 140 in the study died of Aujeszky's disease despite an apparent good vaccine integration with presence of anti-gB Ab and presence of neutralizing Ab 2 months before encountering the virus. This study presents encouraging first results with a good safety and a good efficacy of the vaccine in hunting dogs, but the efficacy of the vaccine.La maladie d'Aujeszky ou pseudorage est causée par le virus Suid Herpesvirus type 1. Elle infecte les Suidés, réservoirs de la maladie, et peut provoquer chez le chien une mort fatale en quelques heures à jours avec comme signe clinique caractéristique un prurit démentiel. Actuellement, la France est indemne de la maladie d'Aujeszky en élevages de porcs mais le virus continue de circuler chez les sangliers. Depuis 2016, il est détecté une augmentation du nombre de chiens morts de la maladie d'Aujeszky en période de chasse aux sangliers. En l'absence de traitement, les vétérinaires sont de plus en plus sollicités par les propriétaires de chiens de chasse pour les vacciner. Cette étude visait à estimer l'innocuité et l'efficacité du vaccin AUSKIPRA® BK, disponible en France hors AMM avec une ATU chez le chien de chasse, par une étude réalisée dans le département de l'Aube. Par dosage des anticorps (Ac) anti-gB sur 328 sangliers, la séroprévalence a été estimée à 22,6 % chez le sanglier dans le département durant l'année cynégétique 2021-2022. Une étude de cohorte a porté sur 149 chiens de chasse du même département la même année, qui ont été vaccinés avec deux injections de primo-vaccination et un rappel à 6 mois. Les effets indésirables ont été recensés sur 90 chiens par les propriétaires et vétérinaires : 45,6 % des chiens n'ont présenté aucun signe clinique suite aux injections vaccinales, 34,4 % au moins un épisode de signes cliniques locaux au site d'injection avec majoritairement un gonflement (22,2 %), de la chaleur (13,3 %) et de la douleur (5,6 %) ; 31,1 % au moins un épisode de signes d'atteinte de l'état général avec en majorité une prostration (18,9 %) et une modification de l'appétit (12,2 %) dans les jours suivants l'injection ; 11,1 % au moins un épisode de signes graves avec des vomissements (4,4 %) et des difficultés respiratoires (3,3 %) avec résolution de la majorité des signes cliniques dans les heures voire jours suivant la vaccination. Quatre prises de sang ont été réalisées chez les chiens de l'étude afin de doser les Ac anti-gB par méthode ELISA compétition. Le vaccin a permis une séroconversion en Ac anti-gB de tous les chiens vaccinés suite aux deux injections de primo-vaccination et 97,7 % des chiens étaient toujours séropositifs 6 mois après la primo-vaccination, montrant ainsi une bonne efficacité vaccinale. Une séroneutralisation a été réalisée chez 31 chiens de l'étude montrant une acquisition d'Ac séroneutralisants pour 80,6 % d'entre eux suite aux deux injections de primo-vaccination, avec une diminution jusqu'à 25,8 % dans les 6 mois, avant le rappel. Le dosage des Ac anti-gE par ELISA compétition a permis de détecter un chien sur les 140 ayant rencontré le virus et ayant survécu. Ce dernier possédait des Ac anti-PrV vaccinaux au moment du contact avec le virus et séroneutralisants après contact. Par ailleurs, malgré une apparente bonne intégration vaccinale avec présence d'Ac anti-gB et présence d'Ac neutralisants 2 mois avant de rencontrer le virus, un chien vacciné est décédé de la maladie d'Aujeszky. Cette étude présente des premiers résultats encourageants avec une bonne innocuité et une bonne efficacité vaccinale chez le chien de chasse mais l'efficacité du vaccin reste encore incertaine à ce jour. Une prolongation de cette étude sur l'année 2022-2023 est en cours dans le même département
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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