2,047 research outputs found
Classroom by Classroom, School by School: A Lens on the Past, A Vision of the Future
No full textPublished by and copyright by National Council for the Social StudiesOffers examples of collaboration between teachers and university professors. Provides an overview of the past twenty-five years of social studies research and reform. Argues for the importance of reconceptualizing the traditional school/university relationship to overcome barriers between teachers and researchers
Caught in the Current: A Self-Study of State-Mandated Compliance in a Teacher Education Program
No full textThis qualitative self-study examines the impact of California???s state-mandated revision of teacher education programs on a department???s???and individual faculty members??????approach to teacher education. In spite of claims by respondents that this process had little impact on their approach to teaching, the authors??? analysis of interview and conversational data and documents suggests otherwise. Faculty members??? increased use of technocratic language and terminology reflecting compliance with the new state standards reveals a substantive shift in the ways they think about what they do
Classroom by Classroom, School by School: A Lens on the Past, A Vision of the Future
No full textOffers examples of collaboration between teachers and university professors. Provides an overview of the past twenty-five years of social studies research and reform. Argues for the importance of reconceptualizing the traditional school/university relationship to overcome barriers between teachers and researchers.Published by and copyright by National Council for the Social StudiesKornfeld, John and Perry M. Marker. Classroom by Classroom, School by School: A Lens on the Past, A Vision of the Future. Theory and Research in Social Education (1997), 25.4: 492-99.0093-310
Pentraxin-3 as a Marker of Advanced Atherosclerosis Results from the Bruneck, ARMY and ARFY Studies
No full textPubMed ID: 22319633This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Jasper County Courthouse Marker, Ridgeland, SC
No full textJasper County Courthouse Marker, Ridgeland, SC.
This marker is located on the courthouse grounds in Ridgeland, Georgia.
The text reads as :
This county was established in 1912 from portions of Beaufort and Hampton counties and named, it is said, for Sergeant William Jasper, hero of the American Revolution. The same act establishing the new county also designated Ridgeland (incorporated 1894) as the county seat. Charles E. Perry, John M. Langford, J. H. Woods, J. P. Wise and Rodger Pinckney were first county commissioners.
Erected by Ivy Garden Club - 1993https://digitalcommons.unf.edu/historical_architecture_main/4268/thumbnail.jp
Bcl2 is an independent prognostic marker of triple negative breast cancer (TNBC) and predicts response to anthracycline combination (ATC) chemotherapy (CT) in adjuvant and neoadjuvant settings
No full textBackground: TNBC represents a heterogeneous subgroup of BC with poor prognosis and frequently resistant to CT. Material and methods: The relationship between Bcl2 immunohistochemical protein expression and clinicopathological outcomes was assessed in 736 TNBC-patients: 635 patients had early primary-TNBC (EP-TNBC) and 101 had primary locally advanced (PLA)-TNBC treated with neo-adjuvant- ATC-CT. Results: Negative Bcl2 (Bcl2-) was observed in 70% of EP-TNBC and was significantly associated with high proliferation, high levels of P-Cadherin, E-Cadherin and HER3 (P’s<0.01), while Bcl2+ was significantly associated with high levels of p27, MDM4 and SPAG5 (P<0.01). After controlling for chemotherapy and other prognostic factors, Bcl2- was associated with 2-fold increased risk of death (P=0.006) and recurrence (P=0.0004). Furthermore, the prognosis of EP-TNBC/Bcl2- patients had improved both BC-specific survival (P=0.002) and disease-free survival (P = 0.003), if they received adjuvant-ATC-CT. Moreover, Bcl2- expression was an independent predictor of pathological complete response of primary locally advanced triple negative breast cancer (PLA-TNBC) treated with neoadjuvant-ATC-CT (P=0.008). Conclusion: Adding Bcl2 to the panel of markers used in current clinical practice could provide both prognostic and predictive information in TNBC. TNBC/Bcl2- patients appear to benefit from ATC-CT, whereas Bcl2+ TNBC seems to be resistant to ATC-CT and may benefit from a trial of different type of chemotherapy with/without novel-targeted agents. Key words: anthracyclin chemotherapy, Bcl2, predictive marker, prognostic marker, theraputic targets, triple negative breast cancer
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
No full textElevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets
Relative Navigation for Debris Removal (RENDER): Designing a Novel Fiducial Marker System
No full textTo mitigate the growth of space debris, it is vital that Active Debris Removal (ADR) is performed in the near future. Since ADR will require robust relative navigation, future spacecraft should be marked with fiducial markers that are robustly extracted from an image taken by a chaser spacecraft. To prevent the restriction of robotic movement and occlusions of features, planarity of these fiducials is desired. While numerous planar fiducials exist, the performance of these systems suffers from pose ambiguities and loss of precision under frontal observations. In order to mitigate these issues, encoding markers have been proposed in literature. These markers encode an extra dimension of information in the signal between marker and sensor, thus increasing the robustness of the fiducial system. However, little research has been done on these encoding markers and existing solutions are hard to manufacture, qualify and scale. This thesis proposes a novel fiducial marker design based on the compound eye of a Mantis insect. The fiducial proposed in this work, the so-called Mantis Marker, is planar and encodes a virtual point in its signal. This virtual point is located at a distance from the marker plane. This makes the marker system mathematically equivalent to a fiducial that uses a protrusion or indentation. This increases pose robustness by an order of magnitude with respect to planar fiducials of the same dimensions, as demonstrated in this thesis. Furthermore, the marker is easy to manufacture, is scalable and has low complexity. Finally, the marker is suitable for pose estimation for robotics and Augmented Reality (AR) on Earth where additional pose robustness is required.Aerospace Engineerin
Precision of determining bone pose and marker position in the foot and lower leg from computed tomography scans: How low can we go in radiation dose?
No full textComputed tomography (CT) imaging can be used to determine bone pose, sometimes combined with skin-mounted markers. For this specific application, a lower radiation dose than the conventional clinical dose might suffice. This study aims to determine how lowering the radiation dose of a CT-scan of the ankle and foot affects the precision of detecting bone pose and marker position. Radiation dose is proportional to tube charge. Hence, an adult cadaveric leg was scanned 10 times at four different tube charges (150, 75, 50 and 20 mAs) with a Philips Brilliance 64 CT scanner. Precision of detecting bone and marker position at 50 mAs was not significantly different from 75 mAs and from the clinically used 150 mAs, but higher than 20 mAs. Furthermore, no differences of the precision in detecting bone orientation were found. These results indicate that the radiation dose can be reduced by a factor 3 compared to the clinically usual radiation dose, without affecting the precision of detecting bone pose and marker position in the foot and ankle.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Biomechatronics & Human-Machine Contro
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"Como" in Commute: The Travels of a Discourse Marker Across Languages
No full textThe present investigation is a mixed method study combining quantitative and qualitative analyses to explore the use of "como" as a discourse marker in the Spanish spoken in Southern Arizona, based on a corpus of twenty-four sociolinguistic interviews of young male and female Spanish-English bilinguals. In a data set of 1148 occurrences of "como," 21.3% fulfill a focus discourse function, 2.2% fulfill a quotative discourse function, and 76.5% fulfill a lexical function. The analysis of young Spanish-English bilinguals using "como" in Spanish to fulfill discourse functions of "like" in English sheds light on how bilinguals structure discourse by drawing from both languages. The results of this study on the diffusion of the focus and quotative "como" to another Spanish-English bilingual community add to our knowledge of how discourse markers can travel both within and between communities and across languages
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