169,813 research outputs found
A GIS-aided Method for an Assessment of the Sliding Susceptibility of Volcanic Soils in Campania (Italy)
No full textA deep, stratigraphically and structurally controlled landslide: the case of Mount La Civita (Molise, Italy)
No full textThe present paper illustrates the results of an integrated
study of a large landslide located on the southern slope of Mount la
Civita (Molise, Southern Apennine), an E–Welongated, SSE dipping
and 890-m-high monocline carbonate ridge. The upper part of the
slope affected by the landslide is largely controlled by strata attitude
while its basal part ismarked by a strike–slip fault causing the tectonic
juxtaposition of the carbonate successions against predominantly
clayey flysch units. An integrated study, including geological, geomorphological
and geotechnical investigations, was carried out to determine
the features of the landslide and to plan further investigation
and monitoring. In particular, from 2002 to 2004, Differential Global
Positioning System monitoring and core drillings, coupled with inclinometermeasurements,
were carried out to determine the landslide’s
kinematics, extent, depth to the surface of rupture and rates of
movement. Inclinometer data revealed the presence of the rupture
surface at a depth of about 20m. DGPS monitoring allowed rates of
movement up to several tens of centimetres per year to be recorded.
The nearby village of Civitanova del Sannio can still be considered at
risk due to the landslide, as recent remedial works, consisting mainly
of very shallow re-shaping of the slope by blasting and partial filling of
trenches, did not succeed in stopping its movement
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A Quantum Circuit to Execute a Key-Recovery Attack Against the DES and 3DES Block Ciphers
No full textQuantum computing enabled cryptanalytic techniques are able to concretely reduce the security margin of existing cryptographic primitives. While this reduction is only polynomial for symmetric cryptosystems, it still provides a reduction in their security margin.
In this work, we propose a detailed quantum circuit designed to cryptanalyze both the Data Encryption Standard (DES) cryptosystem, and its successor Triple-DES (3DES), currently
standardized in ISO/IEC 18033-3, and still widely employed in satellite data and bank card encryption. To do so, we introduce the first quantum circuit implementation of the 8 substitution tables (a.k.a. S-boxes), applying a bitslicing strategy, which is currently the most efficient classical combinatorial circuit design in terms of number of two inputs Boolean gates. Secondly, we present the complete quantum circuits required to attack
both DES and 3DES leveraging Grover’s algorithm. We provide finite regime, closed form equations, delineating the circuits complexities in terms of the number of qubits, gates, depth and number of qubits multiplied by depth. The complexity analysis is based on two distinct gate sets: a NOT-CNOT-Toffoli (NCT) extended with the Hadamard gate; and the fault-tolerant Clifford+T. Finally, akin to the classical attack to the 3DES, we introduce a meet-in-the-middle strategy relying on an exponential amount of Quantum Random Access Memory. Our findings show that the 3DES with keying option 2, the most widely
employed variant of 3DES, can be attacked with a circuit depth of approximately 2^{67} and less than a thousand qubits. This is close to the 2^{64} value suggested by NIST for the depth achievable sequentially by a single quantum computer in a decade. Our technique can be further sped up parallelizing the approach onto multiple devices, pointing to the practicality of cryptanalyzing 3DES in such a scenario
Itinerario 8. Isola di Capri
No full textNella guida sono descritti - con un approccio divulgativo scientifico e in dettaglio - gli affioramenti geologici, gli elementi strutturali e gli aspetti geomorfologici dell’Isola di Capri, anche mediante un itinerario via mare e a terra. In particolare, questi aspetti sono illustrati mediante una carta geologica schematica con indicazione dell'itinerario e dei vari stop, nonché sono approfonditi con numerose fotografie degli affioramenti rocciosi e dei fossili, disegni di colonne stratigrafiche e schemi dell’evoluzione morfologica a colori
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Functions of the native NPM1 protein and its leukemic mutant
No full text: The nucleophosmin (NPM1) gene encodes for the most abundant nucleolar protein. Thanks to its property to act as histone chaperone and to shuttle between the nucleus and cytoplasm, the NPM1 protein is involved in multiple cellular function that are here extensively reviewed and include the formation of the nucleolus through liquid-liquid phase separation, regulation of ribosome biogenesis and transport, control of DNA repair and centrosome duplication as well as response to nucleolar stress. NPM1 is mutated in about 30-35% of adult acute myeloid leukemia (AML). Due to its unique biological and clinical features, NPM1-mutated AML is regarded as a distinct leukemia entity in the WHO 5th edition and ICC classifications of myeloid malignancies. The NPM1 mutant undergoes changes at the C-terminus of the protein that leads to its delocalization in the cytoplasm of the leukemic cells. Here, we focus also on its biological functions discussing the murine models of NPM1 mutations and the various mechanisms that occur at cytoplasmic and nuclear levels to promote and maintain NPM1-mutated AML
Novel Soy Germ Pasta Enriched in Isoflavones Ameliorates Gastroparesis in Type 2 Diabetes : A pilot study
No full textOBJECTIVE: To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis. RESEARCH DESIGN AND METHODS: This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1/2) was measured using the [13C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load. RESULTS: Soy germ pasta significantly accelerated the t1/2 in these patients (161.2 ± 17.5 min at baseline vs. 112.6 ± 11.2 min after treatment, P = 0.009). Such change differed significantly (P = 0.009) from that for conventional pasta (153.6 ± 24.2 vs. 156.2 ± 27.4 min), without affecting glucose or insulin concentrations. CONCLUSIONS: These findings suggest that soy germ pasta may offer a simple dietary approach to managing diabetic gastropathy
- …
