130,834 research outputs found
Transforming growth factor beta-1 and interferon-alpha in the AIDS dementia complex (ADC): possible relationship with cerebral viral load?
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Stability of cruciform specimens for fracture tests under compression
No full textCruciform specimens have been developed in the last decades in order to evaluate the fatigue and fracture material behaviour under biaxial stress fields. These evaluations have been generally conducted under positive load ratios, so as to prevent the potential buckling of these generally thin specimens. This paper reports a numerical investigation on the stability of two cruciform specimens in order to provide useful information for the design of biaxial fracture tests under both tension and compression. Two cruciform geometries were selected among those widely accepted in literature and slightly modified so as to apply equal boundary conditions. FEM simulations were performed under tensile and compressive loading conditions by considering geometric imperfections based on the superposition of the buckling modes. Results were cross-compared in terms of stress fields, load–displacement curves, stress intensity factors and critical loads along crack propagation. Guidelines of general validity were derived
Tolerance does not develop to the suppressant effects of (-)-norpseudoephedrine on ingestive behavior in the rat.
No full text(-)-Norpseudoephedrine (NPE), the enantiomer of cathine and a structural analog of phenylpropanolamine, shows anorectic and antidipsic effects that have been referred to its structural analogies with amphetamine. When amphetamine is chronically administered to rats, its anorectic effects fade out, water intake is progressively increased, and the diuretic response to the drug remains stable. Our previous studies show that chronic administration of NPE does not produce the typical amphetamine hyperdipsic response. In the present study, designed to obtain a more detailed picture of the ingestive and diuretic effects of chronic exposure to NPE, we evaluated the effects of 11 daily administrations of three doses of NPE (17, 32, and 56 mg/kg IP) on food and water intake, as well as on diuresis, in rats maintained in conditions of free access to food and water. Results show that all three doses inhibited food intake at 2 h, whereas only the highest dose inhibited food intake at 5 h. No differences between groups were detected at 24 h. These responses remained unchanged throughout the 11 days of treatment, and substitution of NPE with a solvent injection caused no rebound feeding. NPE treatment did not modify the ingestive response to a challenge injection of amphetamine, 0.56 and 1.0 mg/kg IP, given 1 day apart. Although NPE inhibited water intake throughout the experiment, it did so significantly only during the first 2 h postinjection. Urine output in the NPE-treated groups increased significantly on the first day only. These findings make it unlikely that the anorectic effects of NPE depend on an amphetamine-like mechanism of action. In addition, the short-lasting anorectic and antidipsic effects of NPE and the lack of tolerance to them raise the possibility of a therapeutic use of this drug as an adjuvant in the therapy of eating disorders characterized by binge episode
EFFETTI SULLA COLECTOMIA TOTALE SUL SURRENE. INDAGINI SPERIMENTALI SUL RATTO NOTA I: TECNICHE MICROCHIRURGICHE
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What is the correlation between soluble CD23 and IgE levels in human immunodeficiency virus-1 infection?
No full textBidirectional microwave and optical signal dissemination
No full textAbstract not availablePhilip S. Light, Ashby P. Hilton, Richard T. White, Christopher Perrella, James D. Anstie, John G. Hartnett, Giorgio Santarelli and Andre N. Luite
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