170,320 research outputs found
Edinburgh_NIH10
No full textThis data set contains 10 normal healthy subjects ('sub-001' to 'sub-010') from a larger NIH funded project (NIH grant R01 EB004155) investigating changes in water diffusion parameters with age. Subjects underwent structural and diffusion MRI at 1.5 T and provided images suitable for a wide range of analyses, e.g. tractography, connectome etc
Quantifying the time course of visual object processing using ERPs: it's time to up the game
No full textHundreds of studies have investigated the early ERPs to faces and objects using scalp and intracranial recordings. The vast majority of these studies have used uncontrolled stimuli, inappropriate designs, peak measurements, poor figures, and poor inferential and descriptive group statistics. These problems, together with a tendency to discuss any effect p < 0.05 rather than to report effect sizes, have led to a research field very much qualitative in nature, despite its quantitative inspirations, and in which predictions do not go beyond condition A > condition B. Here we describe the main limitations of face and object ERP research and suggest alternative strategies to move forward. The problems plague intracranial and surface ERP studies, but also studies using more advanced techniques – e.g., source space analyses and measurements of network dynamics, as well as many behavioral, fMRI, TMS, and LFP studies. In essence, it is time to stop amassing binary results and start using single-trial analyses to build models of visual perception
Masks2Metrics (M2M): A Matlab Toolbox for Gold Standard Morphometrics
No full textHuman brains undergo morphometric changes over a lifetime, from conception through to birth, infancy, adolescence, adulthood, and old age (Thambisetty et al. (2010); Madan and Kensinger (2016)). This is further compounded by the changes associated with var-ious brain pathologies such as tumours (e.g. Bauer et al. (2013)) and dementia (e.g., B. C. Dickerson et al. (2011)). It is therefore essential to accurately and scientifically characterise such changes by using an array of morphologic measurements, for a better un-derstanding of the natural progression of ageing and disease (Mills et al. (2016); Madan (2017)). While many existing brain image analysis tools (e.g., FreeSurfer (Fischl et al. (2004); Desikan et al. (2006)), BrainSuite (Shattuck and Leahy (2002)), and BrainVISA (Kochunov et al. (2012))) automatically compute such data from a 3-dimensional (3D) brain image, they lack the ability to do so for the equivalent manually-traced regions of interest (ROIs). This is all the more significant as such ROIs are considered as the gold standard, thus making knowledge of their metrics essential. We have developed an automated Matlab-based tool, Masks2Metrics (Mikhael and Gray (2017)), that calculates three metrics for a given ROI in a 3D image: thickness, volume and suface area. An ROI is defined by a pair of binary masks (in NIfTI file format) representing its outer and inner borders, each of which are drawn continuously along one direction (x-, y-or z-axis). In the specific case of brain images, when the ROI describes a gyrus, its paired masks would correspond to grey matter (GM) and white matter (WM) curves. The paired ROI NIfTI (.nii) masks are expected to be of the form subjroihemgm/wmsegments.nii. For example, a pair corresponding to subject 1's right SFG (superior frontal gyrus) would be 1sfgrgm1.nii and 1sfgrwm1.nii. A special feature of M2M is that multiple pairs, or segments, can be used rather than a single continuous ROI. These segments can be manually or automatically derived. The gener-ated ROI metrics are grey matter thickness (GMth), grey matter volume (GMvol),and white matter surface area (WMsa), also classically calculated by popular existing au-tomated tools (Fischl2000; Shattuck2002) . Additionally, the ROI's corresponding mean Fréchet(Ursell (2013)) and mean Modified Hausdorff Distance (SasiKanth (2011)) are calculated and saved as matrices
Solidarité du travail et du capital ou Organisation du crédit en France / par C. Pernet
No full textAvec mode text
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
A 0.12mm<sup>2</sup> Wien-Bridge Temperature Sensor with 0.1°C (3σ) Inaccuracy from -40°C to 180°C
No full text Resistor-based temperature sensors can achieve much higher resolution and energy efficiency than conventional BJT-based sensors [1], but they typically occupy more area (> 0.25 mm 2 ) and have lower operating temperatures (le 125 {circ} {C}) [2]-[4]. This work describes a 0.12mm 2 resistor-based sensor that uses a Wien-bridge (WB) filter to achieve 0.1 {circ} {C} (3 sigma) inaccuracy from - 40 {circ} {C} to 180 {circ} {C}. Compared to a state-of-the-art WB sensor [4], it occupies 6 × less area and achieves comparable relative accuracy over a 76% wider operating range. Session 10.3 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
La monnaie celtique, de la Guerre des Gaules à l’avènement d’Auguste, 60-30 av. J.-C.
No full textInternational audienc
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