103,315 research outputs found
Using Perl for Statistics: Data Processing and Statistical Computing
No full textIn this paper we show how Perl, an expressive and extensible high-level programming language, with network and ob ject-oriented programming support, can be used in processing data for statistics and statistical computing. The paper is organized in two parts. In Part I, we introduce the Perl programming language, with particular emphasis on the features that distinguish it from conventional languages. Then, using practical examples, we demonstrate how Perl's distinguishing features make it particularly well suited to perform labor intensive and sophisticated tasks ranging from the preparation of data to the writing of statistical reports. In Part II we show how Perl can be extended to perform statistical computations using modules and by "embedding" specialized statistical applications. We provide example on how Perl can be used to do simple statistical analyses, perform complex statistical computations involving matrix algebra and numerical optimization, and make statistical computations more easily reproducible. We also investigate the numerical and statistical reliability of various Perl statistical modules. Important computing issues such as ease of use, speed of calculation, and efficient memory usage, are also considered.
Games, Diversions & Perl Culture: Best of the Perl Journal
No full textThe Perl Journal (TPJ) did something most print journals aspire to, but few succeed. Within a remarkable short time, TPJ acquired a cult-following and became the voice of the Perl community. Every serious Perl programmer subscribed to it, and every notable Perl guru jumped at the opportunity to write for it. Back issues were swapped like trading cards. No longer in print format, TPJ remains the quintessential spirit of Perl--a publication for and by Perl programmers who see fun and beauty in an admittedly quirky little language. Games, Diversions, and Perl Culture is the third volume of T
Quantified aluminium levels released into blood and fluids using the Level 1 Fast Flow Fluid Warmer
No full textPerl Script
No full textThis Perl script enables you to extract the longest open reading frame (ORF) from nucleatide sequence
Perl Testing: A Developer's Notebook
No full textIs there any sexier topic in software development than software testing? That is, besides game programming, 3D graphics, audio, high-performance clustering, cool websites, et cetera? Okay, so software testing is low on the list. And that's unfortunate, because good software testing can increase your productivity, improve your designs, raise your quality, ease your maintenance burdens, and help to satisfy your customers, coworkers, and managers. Perl has a strong history of automated tests. A very early release of Perl 1.0 included a comprehensive test suite, and it's only improved from t
Comparison of <i>H</i>. <i>sapiens</i> perlecan domain IV and <i>T</i>. <i>adhaerens</i> perl 1 and perl 2 domain IV.
No full text<p>The primary structure of domain IV Ig modules were aligned, including all sequences between disulfide-bonded cysteines in each Ig module. The sequences were aligned and residues conserved in 25% or more of these Ig sequences were highlighted. The central Ig modules of <i>H</i>. <i>sapiens</i> domain IV, distinct from the outer Ig modules, are shown separately. Residues of the central Ig modules that are conserved amongst <i>H</i>. <i>sapiens</i> domain IV Ig modules, but not when compared alongside those of <i>T</i>. <i>adhaerens</i>, are outlined with a red dashed line. Ig sequences originating from <i>T</i>. <i>adhaerens</i> perl 1 and perl 2 are shown separately.</p
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis
No full textRATIONALE: The respiratory epithelium has a remarkable capacity to respond to acute injury. In contrast, repeated epithelial injury is often associated with abnormal repair, inflammation and fibrosis. There is increasing evidence that non-ciliated epithelial cells play important roles in the repair of the bronchiolar epithelium following acute injury. Cellular processes underlying the repair and remodeling of the lung following chronic epithelial injury are poorly understood. OBJECTIVES: To identify cell processes mediating epithelial regeneration and remodeling after acute and chronic Clara cell depletion. METHODS: A transgenic mouse model was generated to conditionally express diphtheria toxin A to ablate Clara cells in the adult lung. Epithelial regeneration and peribronchiolar fibrosis were assessed after acute and chronic Clara cell depletion. MEASUREMENTS AND MAIN RESULTS: Acute Clara cell ablation caused squamous metaplasia of ciliated cells and induced proliferation of residual progenitor cells. Ciliated cells in the bronchioles and pro-SPC expressing cells in the bronchiolar alveolar duct junctions did not proliferate. Epithelial cell proliferation occurred at multiple sites along the airways and was not selectively associated with regions around neuroepithelial bodies. Chronic Clara cell depletion resulted in ineffective repair and caused peribronchiolar fibrosis. CONCLUSIONS: Co-localization of proliferation and cell type specific markers demonstrate that Clara cells are critical airway progenitor cells. Continuous depletion of Clara cells resulted in persistent squamous metaplasia, lack of normal re-epithelialization and peribronchiolar fibrosis. Induction of proliferation in subepithelial fibroblasts, supports the concept that chronic epithelial depletion caused peribronchiolar fibrosis
Nosokomiale Pneumonie
No full textPneumonia occurring more than 48 h after induction of mechanical ventilation is called ventilator-associated pneumonia (VAP). VAP is the most common nosocomial infection in intensive care medicine and is associated with prolonged intensive care and hospital stay and a higher mortality. The main pathomechanism for development of ventilator-associated pneumonia is not so much the mechanical ventilation per se but more the pathogens passing along the tube towards the lungs. Avoidance of tracheal intubation, strict hygienic measures, reduction of oropharyngeal colonization and the avoidance of microaspiration are the most promising prevention strategies. Therapeutic success in treatment of VAP is coupled to an early diagnosis and therapy. Suspicion of pneumonia is based on clinical and radiologic criteria. Biomarkers and microbiological findings are important for follow-up and reevaluation of the suspected diagnosis
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