2,718 research outputs found
Novel therapeutic approaches to cancer patients with bone metastasis.
No full textBone metastases are a common event in advanced cancer. Breast, lung, prostate and thyroid neoplasms have striking osteotropism. Bone metastatic cancer may be associated with catastrophic consequences for the patients. Therefore, new strategies are warranted in order to reduce the incidence of bone metastases and to palliative established skeletal disease. External beam radiation therapy, endocrine treatments, chemotherapy, bisphosphonates and radioisotopes are all important. Bisphosphonates have become the treatment of choice for tumor-induced hypercalcaemia and more recently they have been used alone or in combination with cytotoxic agents in the palliative treatment of patients with bone metastases. The results are encouraging. Currently, new bisphosphonates that are a hundred times more powerful with respect to clodronate and pamidronate are under investigation. The treatment of metastases to bone and mechanisms of pain relief after radiation therapy are poorly understood. Up to date, there are not standard criteria for the irradiation of bone metastases and bone pain relief may be reached using a variety of fractionation schemes. Radionuclide therapy is the systemic use of radioisotopes for bone pain. It is currently regarded as suitable for comparison with wide-field irradiation, but appears to have major disadvantages in terms of pain relief and toxicity
A Ten-year-long Update on Radiation Proctitis Among Prostate Cancer Patients Treated With Curative External Beam Radiotherapy
No full textThis comprehensive synopsis summarizes the most relevant information obtained from a systematic analysis of studies of the last decade on radiation proctitis, one of the most feared radioinduced side effects among prostate cancer patients treated with curative external beam radiotherapy. The present review provides a useful support to radiation oncologists for limiting the onset or improving the treatment of radiation proctitis. This work shows that the past decade was a harbinger of significant new evidence in technological advances and technical tricks to avoid radiation proctitis, in addition to dosimetric perspectives and goals, understanding of pathogenesis, diagnostic work-up and treatment. We believe that a well-rounded knowledge of such an issue is fundamental for its appropriate management
Who is the author of the 1876 Stefano manuscript?
Get PDFFor over one hundred years the Stefano manuscript was a private document in the possession of the Baccich family and descendants. It told a story of the 1875 Stefano shipwreck as narrated by the shipwreck survivor and the founding family patriarch Miho Baccich. In these circumstances the question of authorship of the manuscript was immaterial and did not arise as an issue. However, with the publication of the manuscript the author‟s name, or names, need to be formally attributed to it. It turns out that this is not such a clear-cut matter.
As we shall see, all informed sources attributed the authorship, and the ownership, of the manuscript to Miho Baccich. But the manuscript itself was written by Canon Stjepan Skurla – a priest from Miho‟s hometown of Dubrovnik. The question then arises: should Skurla also be considered as an author of the manuscript, or, even as the sole author (as some would have it)
Fashion Culture: Power In Fashion with Stefano Tonchi and Grazia d'Annunzio
No full textStefano Tonchi, global chief creative officer for L’Officiel Group, and Grazia d’Annunzio, former deputy director of Vogue Italia, discuss the power of military uniforms and their influence on high fashion. Tonchi is co-author of the book "Uniform: Order and Disorder.
Introduzione [a I cartolari del notaio Stefano di Corrado di Lavagna]
No full textSaggio introduttivo all’edizione dei frammenti dei protocolli del notaio Stefano di Corrado di Lavagna nel quale viene fatta l’analisi codicologica dei frammenti e si ricostruisce la biografia del notaio. Vengono inoltre esaminate la tipologia dei documenti, le tecniche redazionali del notaio e l’organizzazione burocratica della Chiesa genovese nella seconda metà del secolo XIII.
Introduction essay to the edition of the fragments of the protocols of the notary Stefano di Corrado of Lavagna in which the analysis of the codex fragments and reconstructs the biography of the notary is made by the author. She also examined the types of documents, the technical drafting of the notary and the bureaucratic organization of the Church of Genoa in the second half of the thirteenth century
From Lausanne to Luxembourg: the CJEU’s Seraing Judgment and the Boundaries of Sports Arbitration Under EU Law
No full textIn this expert analysis, Professor Stefano Bastianon dissects the CJEU’s landmark Seraing ruling (Case C-600/23), which reshapes the contours of sports arbitration under EU law. With particular focus on judicial review and EU public policy, the author explores how the Court balances the autonomy of arbitral mechanisms like CAS with the imperative of effective judicial protection — a judgment that could have far-reaching implications for the future of dispute resolution in sport
Recensione di Robert G. La France, Bachiacca: artist of the Medici court, Firenze, Olschki, 2008
No full textABSTRACT ITALIANO
Francesco Ubertini detto il Bachiacca ebbe scarsa fortuna critica ma questo volume di Robert G. La France colma una lacuna grave nella critica d’arte con una solida monografia in lingua inglese che prende in esame tutte le opere e i documenti di questo pittore. Stefano Colonna giudica positivamente il libro, pubblicato da Leo Olschki, limitandosi a sottolineare che alcune opere, inserite come autografe dall’autore, presentino differenti qualità.
ENGLISH ABSTRACT
Francesco Ubertini called Bachiacca has had little critical fortune, but this book by Robert G. La France fills a serious lacuna in art criticism with a solid English monograph that examines all the existing works and documents. Stefano Colonna welcomes the book published by Leo Olschki and simply points out that some of the works included by the author as autograph have a different quality
Xanthogranulomatous Pyelonephritis Can Simulate a Complex Cyst: Case Description and Review of Literature
No full textAbstractXanthogranulomatous pyelonephritis is a rare and peculiar form of chronic pyelonephritis and is generally associated with renal lithiasis. Its incidence is higher in females. The peculiarity of this disease is that it requires a differential diagnosis, because it can often simulate dramatic pathologic conditions. In fact, in the literature are also described cases in association with squamous cell carcinoma of the kidney The radiologic clinical findings simulate renal masses, sometimes in association with caval thrombus. We describe a case of xanthogranulomatous pyelonephritis with radiologic aspects of a complex cyst of Bosniak class III in a man 40-year old
Benefits of image-guided stereotactic hypofractionated radiation therapy as adjuvant treatment of craniopharyngiomas. A review
No full textPurpose: Craniopharyngiomas account for 5.6–13% of intracranial tumors in children. Despite being histologically benign, these tumors remain a major neurosurgical challenge because of the typical tight adherence to adjacent critical structures. The optimal therapeutic approach for this disease is controversial. Large cystic size and adherence to neurovascular, neuroendocrine, and optic structures without a clear line of cleavage make complete resection problematic and often hazardous. For these reasons, partial resection and adjuvant treatment play an important role. Post-operative radiation therapy (RT) following either complete or incomplete tumor removal is associated with significantly decreased recurrence rates. The aim of this review is to analyze the potential advantage of the most modern technical advancements for RT of craniopharyngiomas. Methods: This narrative review on the topic of craniopharyngiomas was based on published data available on PUBMED/Medline. All data concerning adjuvant or upfront radiation therapy treatment of craniopharyngioma were reviewed and summarized. A more detailed analysis of fractionated frameless steretactic radiosurgery of these tumors is provided as well. Results: We reviewed the possible improvement provided by intensity modulated beams, arc therapy, image guidance, proton radiation, and fractionated stereotactic radiosurgery. Many published findings on outcome and toxicity after RT involve the use of relatively outdated RT techniques. Technologic improvements in imaging, radiation planning, and delivery have improved the distribution of radiation doses to desired target volumes and reduced the dose to nearby critical normal tissues. Currently available techniques, providing image guidance and improved radiation doses distribution profile, have shown to maintain the efficacy of conventional techniques while significantly reducing the toxicity. Conclusions: Image-guided radiosurgery holds the dose distributions and precision of frame-based techniques with the remarkable advantage of multiple-session treatments that are better tolerated by sensitive peritumoral structures, such as the optic pathway and hypothalamus. This, together with the comfort of a frameless technique, candidates frameless image-guided radiosurgery to be the first option for the adjuvant post-operative treatment of craniopharyngiomas in children and young adults when total resection cannot be achieved, in particular those with hypothalamic involvement, and when the residual tumor is mostly soli
Patterns of recurrence of bronchioloalveolar cell carcinoma after surgical resection: a radiological, histological, and immunohistochemical study.
No full textBronchioloalveolar carcinoma (BAC) is a subtype of lung adenocarcinoma whose incidence is raising. Bronchioloalveolar carcinoma has a tendency to involve diffusely the lung. No agreement exists about whether diffuse bronchioloalveolar carcinoma has a multicentric or unicentric origin. The purpose of this work is to evaluate the correlation between intrapulmonary spread of bronchioloalveolar carcinoma and its histologic and immunohistochemical characteristics.Surgical specimens of 20 bronchioloalveolar carcinomas with radiologically proved evolution from focal to diffuse disease were retrieved and reviewed. Patterns of pulmonary spread were defined on the basis of CT and MR imaging examinations. Immunohistochemical studies were performed to investigate the expression of gelatinase A and alpha2-integrin. Correlation between immunohistochemical results and patterns of pulmonary spread was evaluated. Statistical evaluation was performed by using Fisher Exact Test.Three histological subtypes of bronchioloalveolar carcinoma were found: mucinous (11 cases), non-mucinous (3 cases), and mixed adenocarcinoma with prominent bronchioloalveolar pattern (6 cases). Three patterns of pulmonary spread were depicted radiologically: parenchymal opacification (11 cases), multiple nodules (7 cases) and mixed pattern (2 cases). Eleven out of 12 mucin-producing versus none out of 8 non-mucin producing cancers developed parenchymal opacification. The difference was statistically significant (P0.033).Diffuse bronchioloalveolar carcinoma may develop from a prior focal cancer. Mucinous subtype is the most prone to develop diffuse disease with parenchymal opacification, probably representing aerogenous spread. Low levels of alpha2-integrin receptors were found in bronchioloalveolar carcinoma which developed parenchymal opacification
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