1,227 research outputs found
Simulazioni e dissimulazioni augustee: Giulia Maggiore, una principessa in esilio.
No full textIl contributo si sostanzia in un'analisi del perseguimento per adulterio e del coinvolgimento invece in un'azione eversiva antiaugustea della figlia del principe Giulia Maggiore. La tradizione letteraria recepisce la vulgata augustea sulla vicenda, ma conserva anche lacerti di una verità alternativa, suggerendo come nel caso di Giulia il governo occultò il coinvolgimento della figlia di Augusto in un realto politico e attribuì arbitrariamente alla donna il reato di adulterio per negare il maturare del dissenso nella stessa domus principis
Giulia Veronica Varisco
No full textThe headword explains the biography and the contribution of the author Giulia Varisco to the children's literatur
Nel nome di Descartes: i variegati percorsi dei cartesiani italiani
No full textIl tratto dialogico dell'approccio cartesiano alla filosofia emerge da questo breve excursus sulla ricezione del pensiero del filosofo in Italia. Vengono pervio' documentati i percorsi intrapresi dai filosofi "cartesiani" che perfezioneranno quel pensiero ancora "rozzo e non perfetto" del loro caposcuola. Un gruppo molto variegato che, influenzato da orientamenti filosofici differenti, restituirà un'immagine inevitabilmente distante da quella del vero Descartes
Il mercato del tartufo, questo perfetto sconosciuto
Get PDFIl tartufo un prodotto di super nicchia? Sicuramente, non solo per l’unicità del profumo e il prezzo a volte proibitivo, ma anche per la storia affascinante sul percorso che fa per arrivare sulle nostre tavole.
Un'indagine volta a capire cosa il mercato conosce del tartufo e dei prodotti derivanti dal tartuf
Hepatocyte Growth Factor (HGF) Modulates Leydig Cells Extracellular Matrix Components.
No full textHepatocyte growth factor (HGF) is a pleiotropic factor that plays a role in organogenesis and development. The multiple actions of HGF are enabled by the c-met receptor, a transmembrane glycoprotein with tyrosine kinase activity, encoded by the MET proto-oncogene. Hepatocyte growth factor (HGF) is a pleiotropic factor that plays multiple roles during mammalian development. We previously demonstrated that in the postnatal testes, the HGF receptor, c-met, is expressed by Leydig cells and HGF increases the steroidogenetic activity of the cells. In the present article, we report that HGF modifies the composition of the extracellular matrix of cultured Leydig cells. We show that HGF increases the metabolic activity of isolated Leydig cells; in particular, the factor increases urokinase plasminogen activator and matrix metalloproteinase 2 secretion. We have also shown that the levels of active transforming growth factor b are increased by HGF. On the contrary, using the Western blotting technique, a strong reduction in the amount of fibronectin present in the culture medium of cells cultured in the presence of HGF has been detected. The presented data demonstrate that HGF modulates several functional activities of Leydig cells, further supporting the hypothesis that this factor has a relevant role in the regulation of mammalian spermatogenesis
«Da matricola a perfetto soldatino». Testimonianze di alunni del Collegio Ghislieri dal fronte 1915-1919
No full textIl catalogo contiene i materiali esposti al Collegio Ghislieri di Pavia in occasione della mostra documentaria inaugurata nel maggio 2015. La mostra ha ricostruito le vicende degli alunni del Ghislieri durante la Grande Guerra a partire della documentazione d'archivio inedita conservata presso l'Archivio Storico del Collegio
Ytterbium Disilicate/Monosilicate Multilayer Environmental Barrier Coatings: Influence of Atmospheric Plasma Spray Parameters on Composition and Microstructure
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Ytterbium Disilicate/Monosilicate Multilayer Environmental Barrier Coatings: Influence of Atmospheric Plasma Spray Parameters on Composition and Microstructure
by Giulia Di Iorio,Laura Paglia *ORCID,Giulia PedrizzettiORCID,Virgilio GenovaORCID,Francesco MarraORCID,Cecilia BartuliORCID andGiovanni PulciORCID
INSTM Reference Laboratory for Materials and Surface Engineering, Sapienza University of Rome, Eudossiana 18, 00184 Rome, Italy
*
Author to whom correspondence should be addressed.
Coatings 2023, 13(9), 1602; https://doi.org/10.3390/coatings13091602
Original submission received: 10 August 2023 / Revised: 31 August 2023 / Accepted: 11 September 2023 / Published: 13 September 2023
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Abstract
SiC/SiC ceramic matrix composites (SiCf/SiC CMCs) are regarded as the new materials for the hot-section components of aircraft gas turbine engines, since they have one-third of the density of metallic superalloys, a higher temperature capability, good mechanical strength, and excellent thermal shock resistance. However, high-temperature water-vapor-rich combustion gases can induce severe surface recession phenomena in SiC/SiC leading to component failure. For this reason, it is necessary to design protective coatings, i.e., environmental barrier coatings (EBCs), able to protect the SiC/SiC surface in combustion environments. In the present work, ytterbium monosilicate (Yb2SiO5), stable when exposed to water vapor at high temperatures, and ytterbium disilicate (Yb2Si2O7), characterized by a thermal expansion coefficient closer to that of the substrate, were selected for a multilayer EBC system. EBCs were processed using the atmospheric plasma spray (APS) technique. A set of deposition parameters were tested, varying the power of the torch, and the composition and microstructure of the deposited coatings were studied in terms of porosity, crack density, and post-deposition phase retention by performing SEM, EDS, and XRD analysis. The results allow for the definition of the influence of deposition parameters on the final properties of multilayer EBC coatings
Diagnosis of secondary amyloidosis in alkaptonuria
Get PDFBackground: Alkaptonuria (AKU) is an inborn error of catabolism due to a deficient activity of homogentisate 1,2-dioxygenase. Patients suffer from a severe arthropathy, cardiovascular and kidney disease but other organs are affected, too. We found secondary amyloidosis as a life-threatening complication in AKU, thus opening new perspectives for its treatment. We proved that methotrexate and anti-oxidants have an excellent efficacy to inhibit the production of amyloid in AKU model chondrocytes. Owing to the progressive and intractable condition, it seems important to detect amyloid deposits at an early phase in AKU and the choice of specimens for a correct diagnosis is crucial.Methods: Ten AKU subjects were examined for amyloidosis; abdominal fat pad aspirates, labial salivary gland, cartilage and synovia specimens were analysed by CR, Th-T, IF, TEM.Results: Amyloid was detected in only one abdominal fat pad specimen. However, all subjects demonstrated amyloid deposition in salivary glands and in other organ biopsies, indicating salivary gland as the ideal specimen for early amyloid detection in AKU.Conclusions: This is, at the best of our knowledge, the first report providing correct indications on the diagnosis of amyloidosis in AKU, thus offering the possibility of treatment of such co-morbidity to AKU patients.Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_185
Hyperreflective Retinal Foci (HRF): Definition and Role of an Invaluable OCT Sign
No full textBackground: Hyperreflective retinal foci (HRF) are small, discrete, hyperreflective elements observed in the retina using optical coherence tomography (OCT). They appear in many retinal diseases and have been linked to disease progression, treatment response, and prognosis. However, their definition and clinical use vary widely, not just between different diseases, but also within a single disorder. Methods: This perspective is based on a review of peer-reviewed studies examining HRF across different retinal diseases. The studies included analyzed HRF morphology, distribution, and clinical relevance using OCT. Particular attention was given to histopathological correlations, disease-specific patterns, and advancements in automated quantification methods. Results: HRF distribution and features vary with disease type and even within the same disease. A variety of descriptions have been proposed with different characteristics in terms of dimensions, reflectivity, location, and association with back shadowing. Automated OCT analysis has enhanced HRF detection, enabling quantitative analysis that may expand their use in clinical practice. However, differences in software and methods can lead to inconsistent results between studies. HRF have been linked to microglial cells and may be defined as neuro-inflammatory cells (Inflammatory, I-HRF), migrating retinal pigment epithelium cells (Pigmentary, P-HRF), blood vessels (Vascular, V-HRF), and deposits of proteinaceous or lipid elements leaking from vessels (Exudative, E-HRF). Conclusions: HRF are emerging as valuable imaging biomarkers in retinal diseases. Four main types have been identified, with different morphological features, pathophysiological origin, and, therefore, different implications in the management of retinal diseases. Advances in imaging and computational analysis are promising for their incorporation into personalized treatment strategies
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