1,313 research outputs found
Individuell frigörelse och kollektivt minne i Eyvind Johnsons självbiografiska romaner
No full textEyvind Johnson si affermò con romanzi autobiografici negli anni Trenta del Novecento, espressione di una corrente letteraria proletaria capace di rendere una materia realistica con una prosa modernista e non convenzionale. La serie di romanzi mostra una tensione tra lo sforzo del personaggio (e del narratore) di tenere in vita la memoria collettiva della Svezia povera e il suo bisogno di emancipazione individuale da un contesto oppressivo. La serie è scritta in terza persona, il che permette l'interazione di empatia e distanza, soggettività e collettività. Con l'aiuto dell'analisi di Philippe Lejeune sull'autobiografia in terza persona, le riflessioni di August Strindberg sul proprio innovativo progetto autobiografico, pure in terza persona, e il concetto del sociologo Maurice Halbwachs della memoria in quanto definita da "quadri sociali", l'articolo mira a mettere in luce questo aspetto in uno dei capolavori della letteratura svedese del Novecento
Random Utility Models, IIA, Mattsson-Weibull-Li Distributionsand a Conjecture by Luce and Suppes
No full textIn recent papers, Mattsson and Weibull, and independently Li, have introduced a class of independent distributions, where the individual cdf’s are powers of each other. For this class they have showed that the choice probabilities are of “Luce form”, i.e. the form following from the Independence from Irrelevant Alternatives (IIA) assumption. We show a converse to this result. For a class of “independent” Random Utility (RU) Models, allowing non-uniform expansion, and where the cdf’s in question are well-behaved in a certain sense, the only possibility is that the cdf’s are of the above mentioned Mattsson-Weibull-Li (MWL) type. This result resolves an old conjecture by Luce and Suppes. The result demands unbounded choice sets. For finite models, we show on the contrary, that any finite independent RU model with Luce form choice probabilities, there is a version with random terms that are not MWL-distributedQC 2012052
Random Utility Models, IIA, Mattsson-Weibull-Li Distributionsand a Conjecture by Luce and Suppes [Elektronisk resurs]
No full textIn recent papers, Mattsson and Weibull, and independently Li, have introduced a class of independent distributions, where the individual cdf’s are powers of each other. For this class they have showed that the choice probabilities are of “Luce form”, i.e. the form following from the Independence from Irrelevant Alternatives (IIA) assumption. We show a converse to this result. For a class of “independent” Random Utility (RU) Models, allowing non-uniform expansion, and where the cdf’s in question are well-behaved in a certain sense, the only possibility is that the cdf’s are of the above mentioned Mattsson-Weibull-Li (MWL) type. This result resolves an old conjecture by Luce and Suppes. The result demands unbounded choice sets. For finite models, we show on the contrary, that any finite independent RU model with Luce form choice probabilities, there is a version with random terms that are not MWL-distributed</p
Small sample sizes, overextraction, and unrealistic expectations: A commentary on M. Mattsson
No full textIn a recent article about the Manchester Driver Behaviour Questionnaire (DBQ), Mattsson (2012) concluded that the factor structure was not invariant across subgroups of respondents. This commentary contests this conclusion
Subsystem functionals in density-functional theory : Investigating the exchange energy per particle
No full textA viable way of extending the successful use of density-functional theory into studies of even more complex systems than are addressed today has been suggested by Kohn and Mattsson [W. Kohn and A. E. Mattsson, Phys. Rev. Lett. 81, 3487 (1998); A. E. Mattsson and W. Kohn, J. Chem. Phys. 115, 3441 (2001)], and is further developed in this work. The scheme consists of dividing a system into subsystems and applying different approximations for the unknown (but general) exchange-correlation energy functional to the different subsystems. We discuss a basic requirement on approximative functionals used in this scheme; they must all adhere to a single explicit choice of the exchange-correlation energy per particle. From a numerical study of a model system with a cosine effective potential, the Mathieu gas, and one of its limiting cases, the harmonic oscillator model, we show that the conventional definition of the exchange energy per particle cannot be described by an analytical series expansion in the limit of slowly varying densities. This indicates that the conventional definition is not suitable in the context of subsystem functionals. We suggest alternative definitions and approaches to subsystem functionals for slowly varying densities and discuss the implications of our findings on the future of functional development
Intracranial facial nerve lesion : experimental study on neural degeneration and its treatment
No full textThe aim of this thesis was to develop an experimental model that would generate extensive motor neuronal degeneration in adult rats, and furthermore to study mechanisms causing nerve cell death and effects of putative neuroprotective compounds. The facial nerve was chosen because it is well characterized and allows evaluation of functional recovery by analyzing vibrissae movements. Using a microsurgical technique, the facial nerve was exposed in the petrosal bone and along its intracranial course in the subarachnoid space where it was cut or compressed near the brainstem. This proximal injury may reflect the situation for some patients suffering from long-lasting facial palsies due to skull-base fractures or tumor growth in the pontine angle.We found that the intracranial portion of the facial nerve was more sensitive than the distal part of the nerve, in terms of neuronal degeneration. A massive motor neuronal death was found after intracranial facial nerve transection (73% cell death after one month). Intracranial facial nerve crush also generated nerve cell death (13% after one month). These data suggest that the intracranial portion of the facial nerve is vulnerable in a unique fashion, in comparison to other peripheral nerves. Furthermore, adult facial motor neurons demonstrated apoptotic death after intracranial transection, in contrast to a distal injury, which is yet another unique response to transection of adult peripheral motor neurons. Moreover, following intracranial transection, reactive microglia transformed into ED I-expressing macrophages, in the ipsilateral facial nucleus, which was not the case after the distal injury. This reaction pattern, which distinguishes intracranial facial nerve transection from the distal lesion as well as from other peripheral nerve injuries, may partly explain the poor outcome that occur in some patients, when the intracranial portion of the facial nerve is lesioned in patients.Several mechanisms have been suggested to contribute to neuronal death following axotomy, such as loss of trophic support from the periphery, accumulation of neurotoxic compounds in the vicinity of neuronal somata, like reactive oxygen species and excitotoxic amino acids. Some of these neurotoxic compounds are released from reactive microglial cells. Here we have studied yet another potential cell death promoting mechanism, the activation of the complement cascade. Using immunocytochemistry and in situ hybridization, we provide evidence for activation of the complement cascade locally in the ipsilateral facial nucleus, in the immediate vicinity to the axotomized neurons. Facial motor neurons also responded with an upregulation of the complement regulators cluster in and CD59. Reactive oxygen species as well as the other neurotoxic components mentioned above, including the complement cascade, may cause an intracellular overload of calcium, however, by different mechanisms. We have therefore within the frame of the present thesis also evaluated potential neuroprotective effects of two antioxidants, betamethasone and the pyrrolopyrimidine PNU-101033-E, as well as the calcium flow antagonist nimodipine. No neuroprotective effects of high-dose betamethasone could be found, however, a dramatic neuroprotective effect of pyrrolopyrimidines as well as nimodipine could be demonstrated. In addition, nimodipine promoted axonal regeneration. We found increased numbers of myelinated axons as well as increased axon and myelin dimensions ipsilateral to intracranial facial nerve crush, and furthermore, an improved facial nerve function, studied by analysis of vibrissae movements.In conclusion, proximal, intracranial lesion of the adult facial nerve cause severe consequences in the facial nucleus in terms of neuronal degeneration, some of which might be due to substances released by reactive microglia, like complement. This intense degeneration can be reversed by administration of pyrrolopyrimidines or nimodipine, both of which may become new strategies for treatment of patients suffering from cranial or other peripheral nerve injuries. We suggest that these drugs should be further evaluated for clinical use.List of scientific papersI. Mattsson P, Meijer B, Svensson M (1999). Extensive neuronal cell death following intracranial transection of the facial nerve in the adult rat. Brain Res Bull. 49(5):333-341. https://pubmed.ncbi.nlm.nih.gov/10452353II. Mattsson P, Delfani K, Svensson M, Janson AM. Motor neuronal and glial apoptosis in the adult facial nucleus after intracranial nerve transection. [Accepted]III. Mattsson P, Morgan BP, Svensson M. (1998). Complement activation and CD59 expression in the motor facial nucleus following intracranial transection of the facial nerve in the adult rat. J Neuroimmunol. 91(1-2):180-189. https://pubmed.ncbi.nlm.nih.gov/9846834IV. Mattsson P, Aldskogius H, Svensson M. (1999). The novel pyrrolopyrimidine PNU-101033-E improves facial motor neuron survival following intracranial axotomy of the facial nerve in the adult rat. J Neurotrauma. 16(9):793-803. https://pubmed.ncbi.nlm.nih.gov/10521139V. Mattsson P, Aldskogius H, Svensson M (1999). Nimodipine-induced improved survival rate of facial motor neurons following intracranial transection of the facial nerve in the adult rat. J Neurosurg. 90(4):760-765. https://pubmed.ncbi.nlm.nih.gov/10193622VI. Mattsson P, Janson AM, Aldskogius H, Svensson M. Nimodipine promotes regeneration and functional recovery after intracranial facial nerve crush. [Submitted]</p
The Political Economy of Flexibility: Deregulation and the Transformation of Corporate Space in the Postwar City of London
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.History, Form & Aesthetic
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