6,384 research outputs found
RDLS-SS-DWT v. 0.9
No full textThis fileset contains the implementation of RDLS-DWT and SS-DWT in JPEG 2000 (RDLS-SS-DWT v. 0.9), which was used in a research described in: R. Starosolski, “Application of reversible denoising and lifting steps to DWT in lossless JPEG 2000 for improved bitrates,” Signal Processing: Image Communication, Vol. 39, Part A, pp. 249-63, DOI: 10.1016/j.image.2015.09.013, 2015 and R. Starosolski, “Skipping selected steps of DWT computation in lossless JPEG 2000 for improved bitrates,” submitted. This software is intended for research purposes only; it is provided "as is"; author makes no warranty of any kind, either express or implied, with respect to this software. <br
Validity of force platform measures of stance stability under varying sensory conditions. Proceedings of National Science Council, ROC: Part B
No full textMagnetic resonance cholangiography for evaluation of cholestatic jaundice in neonates and infants.
No full textReduction-Responsive Nanoparticles Self-Assembled from Sericin-ss-Doxorubicin Conjugate for Hydrophobic IR780 Delivery with Integration of Antitumor Chemo-Phototherapy
Full text linkLulu Zhang,1 Haiyang Liu,1 Jin Ren,2 Junyi Shao,1 Yanrong Cao,1 Shuangshuang Wang,1 Changchun Peng,3 Shengwen Shao,1,2 Haixia Ge,1 Jingmou Yu1,2 1Huzhou Key Laboratory of Medical and Environmental Applications Technologies, School of Life Sciences, Huzhou University, Huzhou, People’s Republic of China; 2Jiangxi Provincial Key Laboratory of Cell Precision Therapy, School of Basic Medical Sciences, Jiujiang University, Jiujiang, 332005, People’s Republic of China; 3Jiangxi Jimin Kexin Pharmaceutical Co., Ltd., Yichun, 332000, People’s Republic of ChinaCorrespondence: Haixia Ge, Email [email protected] Jingmou Yu, Email [email protected]: Stimuli-responsive polymer-drug nanoparticles have emerged as a versatile and effective platform for delivering drugs in the treatment of malignant tumors. The integration of chemo-phototherapy has gained increasing prominence due to its remarkable synergistic antitumor effects.Methods: Hydrophilic sericin (Ser) was linked to antitumor drug doxorubicin (DOX) via a disulfide bond. The obtained Ser-ss-DOX conjugate was characterized by Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR) and dynamic light scattering (DLS). The near-infrared (NIR) fluorescent dye IR780 was encapsulated into Ser-ss-DOX by a dialysis method. The physical state of IR780 within Ser-ss-DOX/IR780 nanoparticles was analyzed by differential scanning calorimetry (DSC). The photothermal properties and drug release behavior of IR780-loaded nanoparticles were systematically investigated. Cellular uptake and reactive oxygen species (ROS) generation capacity and in vitro cytotoxicity of IR780-containing nanoparticles were studied in 4T1 breast cancer cells. In addition, 3D multicellular tumor spheroid model was conducted to investigate the antitumor activity of the nanoparticles.Results: The Ser-ss-DOX conjugate was successfully synthesized. Ser-ss-DOX and Ser-ss-DOX/IR780 nanoparticles were spherical in shape, and their particle sizes measured by DLS were 326 and 190 nm, respectively. IR780 was in an amorphous state within the Ser-ss-DOX/IR780 nanoparticles. The loading contents of DOX and IR780 were 8.26% and 2.78%, respectively. Ser-ss-DOX/IR780 exhibited ideal photothermal properties in vitro and reduction-sensitive drug release in a high glutathione (GSH) environment. Ser-ss-DOX/IR780 displayed higher cellular uptake in 4T1 cells than Ser-ss-DOX and free DOX. Under 808 nm laser irradiation, Ser-ss-DOX/IR780 showed a strong capacity to generate ROS. Importantly, Ser-ss-DOX/IR780 with laser irradiation effectively inhibited the growth of 4T1 cells and 3D multicellular tumor spheroids.Conclusion: This work demonstrated that Ser-ss-DOX/IR780 integrated dual functionalities of chemotherapy and phototherapy, thereby enabling substantial potential for application in tumor treatment. Keywords: polymeric nanoparticles, doxorubicin, sericin, IR780, chemo-phototherap
SS Northland Echo
No full textPhotograph - A view of the steamboat, SS Northland Echo on the Athabasca River. Athabasca, Albert
SS Athabasca River - 02
No full textPhotograph - A view of the SS Athabasca River paddle steamer on the river, Athabasca, Albert
RIC-HSCT for MF/SS
Full text linkAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Prenatal three-dimensional ultrasound and magnetic resonance imaging evaluation of a fetal oral tumor in preparation for the ex-utero intrapartum treatment procedure.
No full textAuricula triangulara Irfan & Zhang & Peng 2022, sp. nov.
No full text<i>Auricula triangulara</i> sp. nov. (ΞssĄḋƦ) <p>Figures 24–29.</p> <p> <b>Types.</b> Holotype ♂, <b>CHINA, Yunnan, Tengchong County:</b> Jietou Township, Longtang He, 0.4 km N of Dahetou Lingganjiao, 25.74277°N, 98.69691°E, alt. 2020m, 17 May 2006, D. H. Kavanaugh and Roberta Brett leg. (DHK –2006–027); <b>Paratypes:</b> 2♂ 3♀, same data as holotype (DHK –2006–027); 3♂, Jietou Township, Dahetou Lingganjiao, 25.73947°N, 98.69630°E, alt. 2010m, 16 May 2006, D. H. Kavanaugh and R. L. Brett leg. (DHK–2006–025C); 1♂ 3♀, Jietou Township, Datang Village, Daheling Ganjiao, 25.74556°N, 98.69630°E, alt. 2030m, 15 May 2006, Xian-jin Peng, Xin-ping Wang and Peng Hu leg. (Peng 060515); 1♀, Tengchong County, Jietou Township, Datang Village, Longtang He river, 25.74556°N, 98.69630°E, alt. 2030m, 20 May 2006, Xianjin Peng and Peng Hu leg. (Peng 060520); 3 ♂ 3♀, Houqiao Township, Gaoshidong, 25.39859°N, 98.30531°E, alt. 2374m, 27 May 2006, Xin-ping Wang and Peng Hu leg. (Wang 060527–2); 1♂, Houqiao Township, 25.35391°N, 98.25488°E, alt. 1785m, 28 May 2006, Xin-ping Wang and Peng Hu leg. (Wang060528–1); 1♀, Mingguang Township, Zizhi Village, 25.78277°N, 98.61633°E, alt. 2200m, 21 May 2006, Ming-wei Yang leg. (YHY10); 1♀, Shangyin Township, Cuanlong Village, 25.00667°N, 98.70992°E, alt. 1990m, 4 June 2006, Chang-min Yin, Jia-fang Hu, Ming-wei Yang and Shao-xian He leg. (YHY10).</p> <p> <b>Etymology.</b> This epithet derives from the Latin adjective “ <i>triangularis</i> ”, meaning “triangular” and referring to the triangular shaped cephalic lobe in male.</p> <p> <b>Diagnosis.</b> See diagnosis of <i>A. aeda</i> <b>sp. nov.</b>.</p> <p> <b>Description. Male</b> (holotype, Fig. 28A–C): Total length: 2.96. Carapace 0.97 long, 0.98 wide, with triangular-shaped cephalic lobe 0.67 long emerging from middle of carapace and extending to a point anteriorly; cephalic pits yellow, present at base of cephalic lobe; fovea, cervical and radial grooves distinct. Clypeus 0.29 high. Sternum longer than wide, yellowish, sparsely covered with microsetae. Labium wider than long. Maxillae long, distal end broad with scopulae. Chelicerae with four promarginal and six retromarginal teeth. Eye region narrow,AER straight, PER procurved slightly wider than AER. Eye sizes and interdistances: AME 0.06, ALE 0.08, PME 0.07, PLE 0.06, AME–AME 0.02, PME–PME 0.09, AME–ALE, 0.05, PME–PLE 0.07, AME–PME 0.05, ALE–ALE 0.36, PLE–PLE 0.43, ALE–PLE contiguous. Length of legs: I 4.69 (1.39, 1.53, 1.13, 0.64), II 4.46 (1.32, 1.46, 1.08, 0.60), III 3.62 (1.11, 1.15, 0.89, 0.47), IV 4.57 (1.33, 1.46, 1.19, 0.59). Leg formula I-IV-II-III. Tm I 0.52 and Tm IV 0.47. Tibial spine formula: 2-2-1-1. Abdomen 1.58 long, 1.38 wide, oval, pale to light gray, dorsally with two longitudinal black bands, ventral side pale.</p> <p>Palp (Figs 24A–D, 25A–D, 26A–D): Patella long, almost equal to the length of cymbium, dorsally with spines; tibia collectively with reterolateral apophysis almost equal to the length of cymbium, with one reterolateral and one dorsal trichobothria, with long, sclerotized, reterolateral tibial apophysis, pointing towards the prolateral side of tibia, distal tip slightly curved with pointed end; paracymbium hook-shaped, distal arm C-shaped with fine plate; tegulum possess long transparent protegulum, distal end strongly curved around the terminal apophysis, protruding above the apex of cymbium; Embolic division: sclerotized, complex, radix, tailpiece, anterior radical process hidden on unexpanded palp; radix somewhat elliptical, with anterior radial process and ear–lobe shaped tailpiece; terminal apophysis J-shaped, sclerotized, protruding above the apex of cymbium; embolus sclerotized, originates from reterolateral margin of the radix, long, distal end curved, protruding above the apex of cymbium.</p> <p> <b>Female</b> (one of the paratypes, Fig. 28D–F): Total length: 3.58. Carapace 1.27 long, 0.96 wide, yellow, mid dorsally slightly elevated; fovea, cervical and radial grooves distinct. Clypeus 0.24 high. Sternum longer than wide, yellow, sparsely covered with microsetae. Labium wider than long. Maxillae long, distal end broad with scopulae. Chelicerae with five promarginal and six retromarginal teeth. Eye region narrow, AER straight, PER procurved slightly wider than AER. Eye sizes and interdistances: AME 0.06, ALE 0.09, PME 0.07, PLE 0.07, AME–AME 0.02, PME–PME 0.07, AME–ALE, 0.04, PME–PLE 0.06, AME–PME 0.05, ALE–ALE 0.35, PLE–PLE 0.39, ALE–PLE contiguous. Length of legs: I 4.8 (1.38, 1.59, 1.15, 0.68), II 4.51 (1.29, 1.49, 1.12, 0.61), III 3.71 (1.09, 1.19, 0.94, 0.49), IV 4.77 (1.39, 1.53, 1.25, 0.60). Leg formula I-IV-II-III. Tm I 0.48 and Tm IV 0.41. Tibial spine formula: 2-2-1-1. Abdomen 1.27 long, 1.79 wide, oval, gray, dorsally with two longitudinal black bands, ventral side dusky gray.</p> <p>Epigyne (Fig. 27A–C): Wider than long, sclerotized; ventral plate concave, connected with dorsal plate by septum to form shallow atrium with copulatory openings posteriorly at the base of septum; dorsal plate sclerotized, mid ventrally with depression; copulatory openings narrow. Vulva with long copulatory ducts, forming pairs of large round loop anteriorly; spermathecae globular, on lateral side of dorsal plate, pointing away from each other, separated by a distance of 2/3 of their diameter.</p> <p> <b>Distribution.</b> Known only from the type locality (Fig. 29).</p> <p> <b> Genus <i>Bathyphantes</i> Blackwall, 1859 (DzƦø)</b> </p>Published as part of <i>Irfan, Muhammad, Zhang, Zhi-Sheng & Peng, Xian-Jin, 2022, Survey of Linyphiidae (Arachnida: Araneae) spiders from Yunnan, China, pp. 1-292 in Megataxa 8 (1)</i> on pages 26-27, DOI: 10.11646/megataxa.8.1.1, <a href="http://zenodo.org/record/7526571">http://zenodo.org/record/7526571</a>
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