1,023 research outputs found
Author Lev Raphael reads from his work at the Michigan Writers Series
No full textInternationally acclaimed author and Greater Lansing resident, Lev Raphael, reads from his memoir "My Germany". He recounts his travels to the NAZI labor camp where his mother was held during World War II and coming to terms with his mother's traumatic past. Introduced by Michigan State University Librarian Michael Rodriguez at an event held at the MSU Main Library. Part of the Michigan State University Libraries' Michigan Writers Series
Abstract LB-271: SplashRNA, a sequential classification algorithm for ultra-potent RNAi
No full textAbstract
We present SplashRNA, a sequential classifier - analogous to face detection algorithms - to predict ultra-potent microRNA-based short hairpin RNAs (shRNAs) for virtually any gene. Trained on existing and novel large-scale datasets, SplashRNA outperforms previous algorithms and reliably predicts the most efficient shRNAs for a given gene. Combined with the optimized miR-E backbone, >90% of high-scoring SplashRNA predictions trigger >85% protein knockdown when expressed from a single genomic integration. SplashRNA can significantly improve the accuracy of loss-of-function genetics studies and facilitates the generation of compact shRNA libraries. The open source SplashRNA platform completes the RNAi toolkit to harness microRNA-based shRNAs for robust single-gene and multiplexed inducible and reversible target inhibition.
Citation Format: Raphael Pelossof, Lauren Fairchild, Christina S. Leslie, Christof Fellmann. SplashRNA, a sequential classification algorithm for ultra-potent RNAi [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr LB-271. doi:10.1158/1538-7445.AM2017-LB-271</jats:p
Deep machine learning of topological states of quantum matter
No full textauthor: Raphael KaubrueggerMasterarbeit Universität Innsbruck 201
Deep machine learning of topological states of quantum matter
No full textauthor: Raphael KaubrueggerMasterarbeit Universität Innsbruck 201
Deep machine learning of topological states of quantum matter
No full textauthor: Raphael KaubrueggerMasterarbeit Universität Innsbruck 201
Vocabulario Portuguez & Latino, Antico ... : Tomo VIII
No full textContén ademáis: Diccionario Castellano y Portuguez para facilitar ... la noticia de la lengua Latina ... Author el P. D. Raphael Blutea
The seated female nude : from Raphael to Ingres
No full textThis article discusses the history and interpretation of the painted female nude from the 15th to the 19th century. The author discusses artists from the Renaissance, such as Raphael up to Impressionism and Neoclassicism by Ingres.peer-reviewe
In the Footsteps of Raphael Lemkin
No full textWhen Raphael Lemkin invented the word ‘‘genocide’’ in 1944, he explained that this is a ‘‘new word, coined by the author to denote an old practice in its modern development.’’1 As Lemkin wrote these words, the paradigmatic genocide, the Holocaust, was raging in Europe
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