1,644 research outputs found

    Harrison L. Peeples, M.D., oral history interview, April 30, 1993

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    Dr. Laurie L. Brown, M.D., conducted this oral history interview on April 23, 1993, at the Medical University of South Carolina in Charleston. In this interview, Dr. Harrison L. Peeples, M.D., discusses his educational background, career in medicine, and tenure as president of the South Carolina Medical Association (SCMA) from 1979 to 1980. During this interview, Peeples describes the issues facing the field of medicine at the time he served as president of the association, which included: Medicare, the socialization of medicine, maldistribution of physicians, and an inadequate supply of physicians. Dr. Peeples also discusses the committees from SCMA which met with the State Board of Education to gain state interest in health and sex education in the classroom, meeting opposition from the majority of the population at the time

    Harrison Forman Diary China, January-May 1942

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    This diary written by Harrison Forman begins on January 10, 1942, just one month after the Japanese bombed Pearl Harbor in the United States, meanwhile, the Second Sino-Japanese War continues in China. On horseback, Forman rides through the deserted streets of Changsha (capital of Hunan province, southeastern China) and reports civilians returning home as the Japanese retreat to the north. Forman travels to Hongshan where he witnessed the cremated remains of Japanese soldiers. On January 11, 1942, Forman interviews Jsueh Yueh (Xue Yue), the Chinese Nationalist General and Commander-in-Chief responsible for the victories over the Japanese at the Second and Third Battles for Changsha. General Xue Yue explained the tactics which contributed to success. Forman then travels the Hsiang River by boat, then by train to Hengyang (south central Hunan province, 110 miles south of Changsha, seat of the Nationalist Party military government) and Kwielin (now Guilin) in the northeastern Zhuang Autonomous region of Guangxi southern China. Forman describes supply trucks arriving from Linchow (now Lanzhou) delivering goods for soldiers and civilians. According to Forman, merchants had begun to stockpile goods after the fall of I-ch’ang (now Yichang, an area heavily bombed and taken by the Japanese Army in 1940) and in fear of fighting in Rangoon (now Yangon, Myanmar (Burma)). Forman mentions Kunming in southwestern China, where the U.S. Major General Claire L. Chennault, founder of the volunteer air squadron the Flying Tigers, were guarding against the Japanese forces. Chinese Nationalist Government officials are mentioned, such as T.S. Tsiang (Tsiang Tingfu, historian and diplomat), Wang Wen-hao (Weng Wen-ho, geologist, educator, and Minister of Economy, 1938-1947), and Wu Ting-chang (Wu Dingchang, Minister of Economic Affairs, 1935). Other notable figures mentioned are, Feng Yachsiang (Feng Yuxiang, Christian General and Chiang Kai-shek supporter), Quo Tai-chi (Dr. Quo Tai-chi, first Chinese representative to Britain, 1932-1940; named foreign minister by Central Executive Committee of the Kuomintang, 1941), Kenji Doihara (“Lawrence of Manchuria,” general of Imperial Japanese Army who invaded Manchuria), Emily “Mickey” Hahn (journalist and author), and Charles Boxer (local head of the British Army Intelligence). Forman follows Wendell L. Willkie, U.S. Republican presidential candidate (opposition to Franklin D. Roosevelt), on his trip to China and mentions a list of notable figures, such as Chu Shao-liang (Zhu Shaoliang, general in the National Revolution Army of the Republic of China), Hu Tsung-nan (Hu Zongnan, trusted general of Chiang Kai-shek), Captain Chiang Wei-kuo, Generals Shi Liang-yu, Li Chen-shen, Chang Tso-lin (Zhang Zuolin, warlord of Manchuria, defeated by the Nationalist Kuomintang in 1928), and Hsu Liang-yo. Forman ends his diary at the close of Willkie’s visit, writing about his press colleagues, Francis Lee and Peter Kiang. He tells of the story “Phanton Legions” in the London Daily Express, written by Tommy Chao.The diaries are part of the Harrison Forman Papers 1931-1974 housed at the Special Collections & University Archives, University of Oregon Libraries. UWM Libraries received the dairies on a loan from the Special Collections & University Archives at the University of Oregon Libraries and digitized them to accompany the digital collection of Forman's photographs. The diaries were digitized to provide research materials for the Forman’s negatives scanned as part of the NEH grant project "Saving and Sharing the AGS Library's Historic Nitrate Negative Images.

    Unfinished memories

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    Exhibition catalogue of Spencer J. Harrison. Jann L.M. Bailey and Anna-Marie Larson of Kamloops Art Gallery wrote the catalogue essay.Not peer reviewedArtist catalogu

    Unfinished memories

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    Exhibition catalogue of Spencer J. Harrison. Jann L.M. Bailey and Anna-Marie Larson of Kamloops Art Gallery wrote the catalogue essay.Not peer reviewedArtist catalogu

    Harrison White and the Practice of Sociology

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    We introduce the topics and foci of the six articles in this special issue devoted to the work of Harrison White, who passed away in May 2024. We asked each author to reveal some aspects of White’s craft, while recounting how their own work has in some respects been entangled with the research problems and vision that he has articulated. Each essay is at once scholarly, innovative, and deeply personal

    Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer

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    This work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe

    President Franklin D. Roosevelt signing the Reciprocal Trade Agreements Act .

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    Handwritten Inscription: \u27Secretary [Henry A.] Wallace, Secretary [Cordell] Hull, Senator Pat Harrison, Congressman [Robert L.] Doughton\u27https://egrove.olemiss.edu/fmjohnston/1073/thumbnail.jp

    The effects of 5-hydroxy-l-tryptophan and exercise on normotensive and hypertensive rats, 1982

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    Scientific studies have shown that serotonin (5-hydroxytryptamine) 5-HT or its precursor 5-hydroxytryptophan (5-HTP) given in large doses causes massive renal necrosis and hypertension in rats. Elo and Tirri (1972) reported that forced motility caused the level of serotonin in rat brain to increase. Fre ter, et ah, 1957 found two isomeric forms of 5-HTP, forms D and L. Erspamer and Bertaccini (1961) found that a great portion of the L form of 5-HTP was responsible for the formation of 5-HT. However they could not rule out the fact that both D and L forms together were necessary for the observed reaction it caused in vivo. This study involved the effects of 5-hydroxy-L-tryptophan (5-L-HTP) and forced motility on rats as it relates to neurogenic hypertension

    Book review: Singing: personal and performance values in training, by Peter Harrison

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    Book review of: Singing: personal and performance values in training, by Peter Harrison. Edinburgh: Dunedin Academic Press; ISBN 9781780460062 (£25.00)Publisher PD
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