154 research outputs found
Diagnostic, Clinical and Post-SARS-CoV-2 Scenarios in Cancer Patients with SARS-CoV-2: Retrospective Analysis in Three German Cancer Centers.
No full textOncologists face challenges in the management of SARS-CoV-2 infections and post-SARS-CoV-2 cancer treatment. We analyzed diagnostic, clinical and post-SARS-CoV-2 scenarios in patients from three German cancer centers with RT-PCR confirmed SARS-CoV-2 infection. Sixty-three patients with SARS-CoV-2 and hematologic or solid neoplasms were included. Thirty patients were initially asymptomatic, 10 of whom developed COVID-19 symptoms subsequently. Altogether 20 (32%) patients were asymptomatic, 18 (29%) had mild, 12 (19%) severe and 13 (20%) critical courses. Lymphocytopenia increased risk of severe/critical COVID-19 three-fold (p = 0.015). Asymptomatic course was not associated with age, remission status, therapies or co-morbidities. Secondary bacterial infection accompanied more than one third of critical COVID-19 cases. Treatment was delayed post-SARS-CoV-2 in 46 patients, 9 of whom developed progressive disease (PD). Cancer therapy was modified in 8 SARS-CoV-2 survivors because of deteriorating performance or PD. At the last follow-up, 17 patients had died from COVID-19 (n = 8) or PD (n = 9) giving an estimated 73% four-month overall survival rate. SARS-CoV-2 infection has a heterogenous course in cancer patients. Lymphocytopenia carries a significant risk of severe/critical COVID-19. SARS-CoV-2 disruption of therapy is as serious as SARS-CoV-2 infection itself. Careful surveillance will allow early restart of the anti-cancer treatment
Impact of pre-OP independence in patients with limited brain metastases on long-term survival
No full textBackground Brain metastasis represents a major complication with a significantly shorter overall survival of many oncological diseases, in particular of lung cancer, breast cancer and malignant melanoma patients. However, despite the poor prognosis, sometimes clinical decision-making, between on the one hand not to harm the patient and on the other hand not withholding a potential therapeutic option, is very challenging. Thus the aim of this retrospective study was to compare various scores, including scores for activities of daily living (ADL) before resection of brain metastases and to analyse their impact on survival. Methods Our single institution retrospective patient cohort (N = 100) with a median age of 63.6 years, which had all undergone resection of one or more brain metastases, was categorized using the original patient files. The cohort includes 52 patients with lung cancer, 27 patients with breast cancer, 8 patients with colorectal carcinoma and 13 patients with kidney cancer. To categorize, we used different score systems which were capable to evaluate the patient in relation to self-sufficiency, activity and self-determination as part of ADL. The retrospective analysis includes the ECOG-Status, Karnofsky-Index, Barthel-Index, ASA-Classification and Katz-Index. Pre-processing and the analysis of the data was implemented using KNIME, where we used the R-plugin nodes to perform the final statistical tests with R. Results Our analysis reveals that most of the ADL scores we tested are able to give a reliable prediction on overall survival after brain metastasis surgery. The survival rates decrease significantly with a lower score in all tested score systems, with the exception of the ASA-Risk score. In particular, the Katz Index < 6 was identified to have a significant correlation with a lower cancer specific survival (CSS) (HR 3.33, 95%-CI [2.17-5.00];p-Value = 9.6*10(- 9)), which is easy to use and has reproducible measurements. Conclusions Pre-operative independence assessment by indices of ADL represents a predictor for overall survival after resection of brain metastases. Especially the easily, objectively and rapidly applicable Katz-Score is a very helpful tool to assess the pre-operative status, which could be additionally included in clinical decision making in daily practice
Die Rolle des Protein-Phosphatase Inhibitor 1 in der initialen Phase nach der transversen Aortenkonstriktion im Mausmodel
No full textGazera heliconioides subsp. micha H. Druce 1896
No full textGazera heliconioides micha (H. Druce, 1896) (Fig. 13) Castnia micha (H. Druce, 1896) Taxonomic history. Described in the genus Castnia by Druce (1896) but later included in the genus Cabirus by Houlbert (1918). Talbot (1919) mentions that micha “can only be considered as a race and not as a distinct species”. Distribution. This subspecies is known from Bolivia, Paraguay and South East Brazil (Miller 1986; Lamas 1995; Rothschild 1919). Jörgensen (1930) states that it is common in all the Eastern region of Paraguay. It is, apparently, together with Castnia invaria penelope, the commonest castniid species in Paraguay. Jörgensen (1930) mentions that it flies in forested areas, near bromeliads (Bromelia sp. and Ananas sp.). It is frequently found perching close to the ground at the base of leaves or grasses and the way the moth rests and its wing and body coloration (Fig. 20 b) allows it to “disappear” in the surroundings. The first author observed individuals flying in urban places of Asunción, the capital city of Paraguay. He also observed them flying in Sapucay, Paraguarí Department and in Cerro Corá, Amambay Department. Ulf Drechsel (pers. comm.) collected and observed specimens in Sapucay, Paraguarí Department, and in Areguá, Central Department; while Contreras (2009) collected them in Ñeembucú Department. Biology and behavior. Like all taxa in the genus, they have a close resemblance to members of Lycorea Doubleday (Nymphalidae: Danainae), Thyridia Hübner and Methona Doubleday (Nymphalidae: Danainae, Ithomiini), and to Notophyson heliconides (Swainson) (Erebidae: Arctiinae, Pericopini) (Miller 1986; Lamas 1973). Two males were observed by the first author in Paraguarí and Amambay Departments, while flying low and slowly, along paths surrounded with Bromelia balansae Mez, which allowed for easy collection. They also perched close to the ground (Fig. 21). These observations clearly contrast with those made by Contreras (2009) in more disturbed habitats, where specimens were found flying fast, strongly and very high (7–8 m above ground).The host plant is unknown, but we suspect that the larvae feed on Bromelia spp. and/or Ananas spp. Contreras (2009) mentions that Orchidaceae could also be hosts of this species. Material examined. 13, Castnia micha Druce, 494, Paraguay (SMNH). CORDILLERA: Caacupé, 22.IX. 1969 (FCA/ DE); 1 Ƥ, Atyrá, X. 2002, Coll. C.Aguilar (MNHNPY). GUAIRÁ: 233,1 Ƥ, “ Paraguay, Independencia”, A. Breyer Collection (MLP); 13, 1 Ƥ, Carlos Pfannl, Paraguay, no date (TPC). CAAGUAZÚ: Coronel Oviedo, 25.X. 1972 (FCA/ DE); 13, “ Paraguay, Caa-Guazú”, XII- 1948, Coll. F.H. Schade, A. Breyer Collection (MLP);. PARAGUARÍ: 13, Sapucay. 8. X. 2008. Coll. S.Ríos (MNHNPY); 13, Sapucay, Paraguay 8.XI. 1997. Coll. U. Drechsel (MNHNPY); 13, Sapucay, Oct. 24, [1] 900 (NHMUM). CENTRAL: San Lorenzo, 23.X. 1985 Coll. J.Estigarribia (FCA/ DE). ÑEEMBUCÚ: 13, Distrito Humaitá, Arroyo Franco Cué, 15.XI. 2006 (IBIS, 1719) (IBIS-UNP); 13, Distrito Isla Umbú, Arroyo Hondo, paraje Itá Cajón, 13.XII. 2006 (IBIS, 2109) (IBIS-UNP). AMAMBAY: 13, Parque Nacional Cerro Corá, 25.X. 2009 Coll. S.Ríos (MNHNPY).Published as part of Ríos, Sergio D. & González, Jorge M., 2011, A synopsis of the Castniidae (Lepidoptera) of Paraguay, pp. 43-61 in Zootaxa 3055 on pages 53-54, DOI: 10.5281/zenodo.27891
Micha Ullman: specific and general
No full textTento text si klade za cíl předvést důležitou edukační interpretační praxi,která souvisí s analýzou edukovaného díla, totiž s budováním zdůvodněnéhokontextu pro vybranou strategii. V první části textu Micha Ullman: sochyna rozhraní nebe – země prozkoumáme dílo autora, který začal tvořit v se-dmdesátých letech a jeho tvorba je kontinuálně vystavována.V druhé části Strategie a její variace: nalezení shodného při vědomí odliš-ností teoreticky zakotvíme odlišnost mezi konkrétní praxí autora a strategiíjako objevenou obecninou. Objevovat strategie, umět je chápat ve spojitostis určitou dobou, znamená, že při významných shodách zároveň zazname-náváme odlišnosti a vsazujeme jev do adekvátního kontextu. Je to jednakvelmi účinná edukativní možnost, jak chápat dějiny oboru v souvislostecha trsech a neutápět se v jednotlivých případech autorských řešení, ale takémožnost, jak pro jednotlivé autory získat výkladový rámec porovnáváníma vyhledáváním shod při podstatných odlišnostech s jinými.This text aims to demonstrate an important educational interpretation prac-tice that is related to the analysis of the educated work, namely to buildinga justified context for the chosen strategy. In the first part of the text MichaUllman: sculptures at the interface of heaven and earth, we will explore thework of the author, who started creating in the seventies and whose workis continuously exhibited.In the second part, Strategy and its variations: finding the same whilebeing aware of differences, we theoretically anchor the difference betweenthe specific practice of the author and strategy as a discovered generality.Discovering strategies, being able to understand them in connection witha certain time, means that in case of significant similarities, we simultaneou-sly note differences and place the phenomenon in an adequate context. It is,on the one hand, a very effective educational opportunity to understand thehistory of the field in contexts and clusters and not to get bogged down inindividual cases of authorial solutions, but also an opportunity to obtain aninterpretive framework for individual authors by comparing and searchingfor similarities in substantial differences with others
The Transreal: Political Aesthetics of Crossing Realities
No full textAuthor of the book: Micha Cardena
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy
No full textPhosphatase inhibitor-1 (I-1) is a conditional amplifier of beta-adrenergic signalling downstream of protein kinase A by inhibiting type-1 phosphatases only in its PKA-phosphorylated form. I-1 is downregulated in failing hearts and thus contributes to beta-adrenergic desensitization. It is unclear whether this should be viewed as a predominantly adverse or protective response. We generated transgenic mice with cardiac-specific I-1 overexpression (I-1-TG) and evaluated cardiac function and responses to catecholamines in mice with targeted disruption of the I-1 gene (I-1-KO). Both groups were compared with their wild-type (WT) littermates. I-1-TG developed cardiac hypertrophy and mild dysfunction which was accompanied by a substantial compensatory increase in PP1 abundance and activity, confounding cause-effect relationships. I-1-KO had normal heart structure with mildly reduced sensitivity, but unchanged maximal contractile responses to beta-adrenergic stimulation, both in vitro and in vivo. Notably, I-1-KO were partially protected from lethal catecholamine-induced arrhythmias and from hypertrophy and dilation induced by a 7 day infusion with the beta-adrenergic agonist isoprenaline. Moreover, I-1-KO exhibited a partially preserved acute beta-adrenergic response after chronic isoprenaline, which was completely absent in similarly treated WT. At the molecular level, I-1-KO showed lower steady-state phosphorylation of the cardiac ryanodine receptor/Ca(2+) release channel and the sarcoplasmic reticulum (SR) Ca(2+)-ATPase-regulating protein phospholamban. These alterations may lower the propensity for diastolic Ca(2+) release and Ca(2+) uptake and thus stabilize the SR and account for the protection. Taken together, loss of I-1 attenuates detrimental effects of catecholamines on the heart, suggesting I-1 downregulation in heart failure as a beneficial desensitization mechanism and I-1 inhibition as a potential novel strategy for heart failure treatment
Grounded, Witness of War
No full textabstract: For my Barrett Honors creative project, I performed George Brant's emotionally gripping and timely one-woman play entitled "Grounded" which tells the story of a fighter pilot who was recommissioned to fly drones after becoming pregnant. The effects of the demanding routine of a drone pilot are masterfully captured as the pilot endures a decline in psychological state caused by the daily circumstances of a pilot fighting in drone warfare. In addition to the performance, I kept a written journal on which I have reflected and summarized in my thesis. The creative project has indeed been one of my most challenging, yet rewarding experiences in performance thus far. With the incredible guidance of Micha Espinosa and Jennifer Linde, I was able to achieve a feat of memorizing and performing an hour and ten minute play that really tested my capacity as an actor. It expanded my skill set as an actor and allowed me to play a female role that escapes the "ingenue role" that I have been cast as constantly in my performance career. I have divided my reflection journal into four separate sections: Statement of Purpose, Background Information on Drone Warfare, Character Development and Methodological Process, Performance Reflection and "Talk-Back." These sections guide the reader through my development from the beginning of the process all the way to final performance
Food piece interview in question-and-answer format with Brunswick author Micha
No full textFood piece interview in question-and-answer format with Brunswick author Michael Sanders. Sanders\u27 new book, From Here, You Can\u27t See Paris: Seasons of a French Village and Its Restaurant, describes the year he spent with his wife and daughter in the village of Les Arques in the Lot region of France
Numerical study on the effects of river bank stabilization
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Environmental Fluid Mechanic
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